Publications by authors named "Zhongkai Hao"

This study aimed to assess the impact of 6 hours of postoperative nasal oxygen therapy on early-stage corneal edema in patients with nuclear cataracts of grades 3 to 4. A retrospective study involved 49 patients (49 eyes) with grades 3 to 4 nuclear cataracts undergoing phacoemulsification and intraocular lens implantation from September 2021 to September 2022. The oxygen group (27 cases) received postoperative nasal oxygen therapy for 6 hours, while the control group (22 cases) received no additional treatment.

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Article Synopsis
  • This study evaluated the effectiveness of metagenomic next-generation sequencing (mNGS) for diagnosing tough corneal infections when standard methods failed.
  • It involved 42 patients and found that mNGS accurately detected pathogens in 90.48% of cases, with 71.43% of those being clinically significant.
  • The results showed that patients treated based on mNGS findings had better health outcomes compared to those without detection, indicating mNGS's potential to improve diagnosis and therapy in corneal diseases.
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The repair mechanism for corneal epithelial cell injuries encompasses migration, proliferation, and differentiation of corneal epithelial cells, and extracellular matrix remodeling of the stromal structural integrity. Furthermore, it involves the consequential impact of corneal limbal stem cells (LSCs). In recent years, as our comprehension of the mediating mechanisms underlying corneal epithelial injury repair has advanced, it has become increasingly apparent that growth factors play a pivotal role in this intricate process.

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Article Synopsis
  • The study presents the first evaluation of pristine metal-organic xerogels as anodes in lithium-ion batteries, highlighting their electrochemical performance.
  • A novel method was developed to create ultrafine cobalt sulfide nanoparticles within humic acid gels, resulting in nanoparticles with an average diameter of about 3 nm.
  • The CoSHA electrodes exhibited impressive lithium storage capacity of 662 mAh/g at 0.1 A/g and maintained stable performance after 900 cycles at 1.0 A/g, attributed to the oxygen-containing groups in humic acid and the small CoS active sites.
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Objective: The purpose of this study is to evaluate the efficacy and safety of the local application of silver nitrate (LASN) as an adjuvant treatment before deep lamellar keratoplasty (DLKP) for fungal keratitis responding poorly to medical treatment.

Methods: A total of 12 patients (12 eyes) with fungal keratitis responding poorly to medical treatment (for at least 2 weeks) were included. LASN was performed using 2% silver nitrate, the ulcer was cleaned and debrided, and then, the silver nitrate cotton stick was applied to the surface of the ulcer for a few seconds.

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Objective: To investigate the clinical characteristics and pathogenic genetic mutations of a Chinese family with anterior segment mesenchymal dysgenesis and congenital posterior polar cataract.

Methods: Through family investigation, the family members were examined via slit lamp anterior segment imaging and screened for eye and other diseases by eye B-ultrasound. Genetic test was performed on the blood samples of the fourth family generation (23 people) via whole exome sequencing (trio-WES) and Sanger sequencing.

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Unlabelled: Generating molecules with desired properties is an important task in chemistry and pharmacy. An efficient method may have a positive impact on finding drugs to treat diseases like COVID-19. Data mining and artificial intelligence may be good ways to find an efficient method.

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Rationale: Nocardia farcinica is an opportunistic pathogen that rarely causes ocular infections. This study reviewed a case of N. farcinica-mediated scleritis involving the corneal limbus.

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The hyperbaric oxygen therapy is often used in the management of acid and base burns of the eyes. However, oxygen is rarely supplied locally through goggles or face mask in ophthalmology. Therefore, in this study, we aim to investigate how oxygen delivery affects eye recovery after injury.

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Three-dimensional (3D) TiO architectures have attracted significant attention recently as they can improve the electrochemical stability and realize the full potential of TiO-based anodes in lithium ion batteries. Here, flower-like rutile TiO spheres with radially assembled nanorods (c-channels) were fabricated via a simple hydrothermal method. The 3D radial architecture affords massive active sites to fortify the lithium storage.

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The development of an economic, environmental-friendly and energy-saving process for the selective depolymerization of lignin is an outstanding challenge. Herein, a novel and efficient visible-light-induced photocatalytic process for the selective depolymerization of lignin model compounds and organosolv lignin was first developed by using perylene diimide (PDI) as a metal-free organocatalyst. Interestingly, it can completely decompose the oxidized lignin models to phenolic and ketone fragmentation molecules with very high selectivity at room temperature under visible light illumination.

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Bimetallic Ni-Cu catalysts feature high activity in CO hydrogenation. However, the primary surface intermediates during reaction are still elusive, making the understanding of the reaction mechanism inadequate. Herein, taking advantage of near-ambient pressure X-ray photoelectron spectroscopy (NAP-XPS), we focused on the mechanistic exploration of CO hydrogenation on the Ni/Cu(100) model catalyst under millibar pressures.

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A sodium benzenesulfonate (PhSO3Na)-functionalized reduced graphene oxide was synthesized via a two-step aryl diazonium coupling and subsequent NaCl ion-exchange procedure, which was used as a support to immobilize tris(bipyridine)ruthenium(II) complex (Ru(bpy)3Cl2) by coordination reaction. This elaborated Ru(bpy)3-rGO catalyst exhibited excellent catalytic efficiency in visible-light-driven reductive dehalogenation reactions under mild conditions, even for ary chloride. Meanwhile, it showed the comparable reactivity with the corresponding homogeneous Ru(bpy)3Cl2 catalyst.

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