HPCAL1 promotes glioblastoma proliferation via activation of Wnt/β-catenin signalling pathway.

Glioblastoma (GBM) is the most prevalent primary malignancy of the central nervous system with obvious aggressiveness, and is associated with poor clinical outcome. Studies have indicated that calcium ion (Ca ) can positively regulate the initiation of malignancy with regard to GBM by modulating quiescence, proliferation, migration and maintenance. Hippocalcin like-1 protein (HPCAL1) serves as a sensor of Ca .

A Modified Sine-Cosine Algorithm Based on Neighborhood Search and Greedy Levy Mutation.

For the deficiency of the basic sine-cosine algorithm in dealing with global optimization problems such as the low solution precision and the slow convergence speed, a new improved sine-cosine algorithm is proposed in this paper. The improvement involves three optimization strategies. Firstly, the method of exponential decreasing conversion parameter and linear decreasing inertia weight is adopted to balance the global exploration and local development ability of the algorithm.