Publications by authors named "Zhonghui Hu"

Background: With advancements in imaging testing and surgical procedures, an increasing number of nodules with smaller diameters and deeper locations have been deemed suitable for surgical intervention. The preoperative localization of these nodules has become essential. In this retrospective single-center study, we aimed to compare the effectiveness and patient comfort associated with the use of a four-hook needle versus a hook-wire needle for preoperative localization.

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  • Vitiligo is an autoimmune disease with limited treatment options, and this study explores a new approach using baricitinib, a JAK inhibitor, combined with narrow-band ultraviolet B (NB-UVB) therapy.
  • In a controlled trial with 33 adults suffering from progressive non-segmental vitiligo, those receiving combination therapy showed a significantly higher improvement rate (70.6%) compared to those receiving NB-UVB alone (12.5%) after 16 weeks.
  • The side effects were mostly minor, suggesting that the combination treatment of baricitinib and NB-UVB is both effective and well-tolerated for vitiligo patients.
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  • *Research has shown that changes to proteins after they are made (post-translational modifications) are important in skin inflammation, but studies on this in vitiligo are still lacking.
  • *The review explores how these protein modifications affect immune responses and the survival of skin pigment cells (melanocytes), and it discusses current and potential new treatments targeting these pathways.*
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  • Mycosis fungoides (MF) is a common skin lymphoma often misdiagnosed due to its non-specific early symptoms, leading to treatment delays; researchers aimed to find urinary biomarkers for early detection of MF through proteomic analysis.
  • A study involving 13 early-stage MF patients treated with interferon α-2a and phototherapy analyzed urine samples before and after treatment, comparing them with healthy controls to identify differentially expressed proteins.
  • The results revealed 41 proteins with significant expression changes, with certain proteins like Serpin B5, epidermal growth factor (EGF), and RhoA showing lower levels in untreated MF patients, but these levels normalized after treatment, indicating potential biomarkers for monitoring MF.
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Alkali-metal doped perovskite oxides have emerged as promising materials due to their unique properties and broad applications in various fields, including photovoltaics and catalysis. Understanding the complex interplay between alkali metal doping, structural modifications, and their impact on performance remains a crucial challenge. In this study, this challenge is addressed by investigating the synthesis and properties of Rb-doped perovskite oxides.

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  • - Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma, and this study assessed the safety and effectiveness of using interferon (IFN) α-2a alongside phototherapy in treating early-stage MF.
  • - Thirteen patients underwent treatment with IFN α-2a injections and phototherapy, resulting in significant improvements in their body surface area (BSA) and severity-weighted assessment tool (mSWAT) scores after 3 and 6 months, with all 13 showing positive responses.
  • - Histopathology indicated a notable decrease in atypical lymphocytes after treatment, and there were no serious side effects, suggesting that this combination therapy is a promising and safe
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Background: Posterior mediastinal leiomyosarcoma is an extremely rare malignant mesenchymal tumor with no special clinical symptoms, which is easily confused with some common tumors in the posterior mediastinum, affecting the accuracy of the first diagnosis by clinicians and delaying the treatment of patients.

Case Summary: We report a 59-year-old woman with a space-occupying lesion in the posterior mediastinum. The patient was mistakenly diagnosed with lumbar muscle or vertebral body lesions due to chest and back pain and underwent conservative treatment, but her symptoms did not improve significantly and she gradually developed pain in both lower limbs.

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Background: The molecular targets and associated mechanisms of hepatocellular carcinoma (HCC) have been widely studied, but the roles of PDZK1 in HCC are unclear. Therefore, the aim of this study is to explore the role and associated mechanisms of PDZK1 in HCC.

Results: It was found that the expression of PDZK1 in HCC tissues was higher than that in paired paracancerous tissues.

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Hypopigmented mycosis fungoides is a rare form of mycosis fungoides that is characterized by achromic lesions, early onset of disease, a predilection for darker skinned populations, and a predominance of CD8+ T cells. Due to the rarity and heterogeneous presentation of hypopigmented mycosis fungoides, there are no criteria that clearly define the clinical characteristics and treatment regimens for this condition. This retrospective study of 44 paediatric patients with hypopigmented mycosis fungoides aimed to summarize their epidemiological and clinical characteristics and assess the effectiveness and safety of different treatment regimens.

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To assess the potential factors with predictive value for survival in small-cell lung cancer (SCLC) patients and to develop a nomogram prediction model. We retrospectively screened and analyzed patients with pathologically confirmed SCLC from April 2015 to December 2021. A total of 167 patients with SCLC were included.

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Uveitis is a rare adverse event of dupilumab, that typically affects both eyes and often leads to discontinuation of therapy. In this article, we report a case of a 28-year-old female with atopic dermatitis who developed new-onset iridocyclitis, a form of uveitis, in her left eye 2 weeks after starting dupilumab treatment, which improved after reducing the dose, without discontinuing dupilumab. The patient also experienced asymptomatic hypereosinophilia, possibly related to dupilumab, which was gradually relieved without discontinuation.

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Background: A comprehensive understanding of the anatomical variations in the pulmonary bronchi and arteries is particularly essential to the implementation of safe and precise left superior division segment (LSDS) segmentectomy. However, no report shows the relationship between the descending bronchus and the artery crossing intersegmental planes. Thus, the purpose of the present study was to analyze the branching pattern of the pulmonary artery and bronchus in LSDS using three-dimensional computed tomography bronchography and angiography (3D-CTBA) and to explore the associated pulmonary anatomical features of the artery crossing intersegmental planes.

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The members of Pleione (Orchidaceae) are popular worldwide due to their beautiful flowers and medicinal values. In October 2021, we observed the typical symptoms of yellow or brown leaves, rotted root, and plant death on P. bulbocodioides (Sup.

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Vitiligo is a common depigmentation disorder of an unknown origin characterized by the selective loss of melanocytes, resulting in typical white macules and patches. However, vitiligo is now recognized as more than just a skin disease, what a dermatologist observes as a white spot of skin is just the "tip of the iceberg" of the condition. We attempt to clarify the classification of comorbidities associated with vitiligo from various reviews and reports, and describe their possible pathogenesis.

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Context: Tumor-associated cutaneous vascular disorder induced by PPGL was extremely rare, and the cutaneous manifestations could disappear after removal of the tumors. However, the definite pathological diagnosis and the potential mechanism remained unidentified. We presented a severe cutaneous vascular lesion manifested as diffuse erythema with ulceration and necrosis over the limbs in a female patient with metastatic paraganglioma.

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Article Synopsis
  • This study examines the factors influencing the growth of pulmonary nodules using immunohistochemical methods, focusing on protein expressions in lung tissue samples.
  • It involved 40 patients with pulmonary nodules, divided into two groups based on whether their nodules grew (growth group) or remained stable (stable group).
  • The results indicated that higher levels of COX-2, Ki67, and VEGF proteins were significantly associated with the growth of nodules, suggesting that VEGF could be a key factor in the development of malignant pulmonary nodules.
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Anisomeles indica (L.) Kuntze is a perennial erect herb that belongs to the genus Epimeredi, family Labiatae (Hsieh et al., 2008).

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Based on social learning theory and the trickle-down effects, in which behavioral patterns cascade from one management level to the next (also known as the falling domino effect), we attempt to answer whether upper-level managers' temporal leadership can be transferred to lower-level managers to form their temporal leadership, and what the mediating mechanisms and boundary conditions for this occurrence are. By analyzing the data from 234 middle-level managers and 686 junior managers/employees, we found that top managers' temporal leadership was positively associated with middle-level managers' temporal leadership through the mediating role of middle-level managers' temporal leadership perspective and that the relationship was moderated by middle-level managers' identification with the top manager. Identification with the top manager, in particular, strengthens both the top manager's positive effect on middle-level managers' temporal leadership and the top manager's temporal leadership's mediating role in this relationship through their temporal leadership perspective.

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Vitiligo is a chronic treatment-resistant autoimmune disorder characterized by circumscribed depigmented maculae. This study was conducted to evaluate the efficacy and safety of tofacitinib combined with narrowband ultraviolet B (NB-UVB) phototherapy for refractory nonsegmental vitiligo. Fifteen patients with nonsegmental vitiligo resistant to conventional therapies were administered oral tofacitinib at 5 mg twice daily plus topical halometasone cream, tacrolimus 0.

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Background: We sought to clarify the electrophysiological (EP) characteristics of premature ventricular contractions (PVCs) with acute successful radiofrequency catheter ablation (RFCA) near the atrioventricular node (AVN).

Methods And Results: Eighteen patients with acute successful RFCA near the AVN were included in this study. Systematic mapping was performed with two mapping methods: antegrade mapping technique (group A) and reversed C curve mapping technique (group R).

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Objective: Lung cancer is a malignancy with high a mortality rate that threatens human health. This study is aimed to explore the correlation among the triglyceride/high-density lipoprotein ratio (TG/HDL-C), non-high-density lipoprotein/high-density lipoprotein ratio (non-HDL-C/HDL-C) and survival of patients with non-small cell lung cancer (NSCLC) undergoing video-associated thoracic surgery (VATS).

Methods: This retrospective study analyzed 284 patients with NSCLC who underwent VATS at Hebei General Hospital, Shijiazhuang, China.

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Objective: The advanced lung cancer inflammation index (ALI) can predict the survival of patients with lung cancer and other malignancies. However, the prognostic significance of ALI in neuroblastoma has not been reported. This study aimed to evaluate the correlation between ALI and neuroblastoma patient prognosis.

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Tomato zonate spotvirus (TZSV) often incurs significant losses in many food and ornamental crops in Yunnan province, China, and the surrounding areas. The pepper (Capsicum chinensePI152225)can develop hypersensitive resistance following infection with TZSV, through an as yet unknown mechanism. The transcriptome dataset showed a total of 45.

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