Rapid quantitative PCR on tongue swabs for pulmonary tuberculosis in adults: a prospective multicentre study.

Background: Tuberculosis (TB) remains a major cause of infectious disease mortality globally, with significant underdiagnosis perpetuating transmission. Tongue swab analysis has emerged as a promising non-invasive method for pulmonary TB diagnosis. This study evaluates the diagnostic accuracy of the TB-EASY quantitative PCR (qPCR) assay using tongue swab specimens.

The association between serum miR-155 and natural killer cells from tuberculosis patients.

Tuberculosis (TB) is still an infectious disease that greatly threatens human health, and is always refractory to the current therapeutic modalities. Accumulated evidence revealed that microRNAs (miRNAs) are closely with various pathologies, such as TB. The possibilities of miRNAs as diagnostic biomarkers and therapeutic targets have been proved.

High serum miR-183 level is associated with the bioactivity of macrophage derived from tuberculosis patients.

As a major health threat, tuberculosis (TB) is resistant against the current therapeutic strategies. Increasing evidence indicates that miRNAs are implicated in various disorders by affecting specific target genes. Recently, the association of miRNAs with TB has also been established by several studies, and their potentials in the prognosis and treatment of TB have also been verified.