Sn-LiTiO/C as a promising cathode material with a large capacity and high rate performance for Mg-Li hybrid batteries.

The development prospects of conventional Li-ion batteries are limited by the paucity of Li resources. Mg-Li hybrid batteries (MLIBs) combine the advantages of Li-ion batteries and magnesium batteries. Li can migrate rapidly in the cathode materials, and the Mg anode has the advantage of being dendrite-free.

Synthesis and electrochemical properties of Mn-doped LiMnTi(PO) materials.

The hunt for a higher power storage, relatively inexpensive, non-polluting battery technology is currently a pressing issue because of the rapid growth of the worldwide economic and the progressively significant environmental pollution. Among the possible nanomaterials for rechargeable batteries that can have heteroatoms applied to it in order to improve its electrochemical behavior is LiTi(PO). Carbon-coated Mn-doped LiMnTi(PO) materials was synthesized by spray drying method.

Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3Kα.

PI3K pathway has been heavily studied and is one of the most potential targets for various cancer treatment. Herein, we designed and synthesized a series of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates contained piperazine based on our previous research. They were evaluated for their PI3Kα wild-type and H1047R mutant inhibitory activities and anticancer effects in vitro.

Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates bearing sulfonylpiperazine as antitumor inhibitors targeting PI3Kα.

PI3K signal pathway plays a vital role in cellular functions and becomes an attractive approach for cancer therapy. Herein, a new series of novel chromeno[4,3-c]pyrazol-4(2H)-one derivatives bearing sulfonylpiperazine based on the PI3K inhibitors and our previous research. They were screened for their PI3K inhibitory activities and anticancer effects in vitro.

Design, synthesis and biological evaluation of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing sulfonamido as potential PI3Kα inhibitors.

A series of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates contained sulfonamido were designed and synthesized, and their anticancer effects in vitro was evaluated to develop some new PI3Kα inhibitors. Most of desired compounds exhibited the better antiproliferative activities against four cancer cell lines than that of LY294002. Out of them, compound 4o displayed the potent antiproliferative activity and high selectivity against the PI3Kα protein and it can induce apoptosis of HCT116 in a dose-dependent manner.

Synthesis, biological evaluation, and metabolic stability of phenazine derivatives as antibacterial agents.

Drug-resistant pathogens are a major cause of hospital- and community-associated bacterial infections in the United States and around the world. These infections are increasingly difficult to treat due to the development of antibiotic resistance and the formation of bacterial biofilms. In the paper, a series of phenazines were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive (methicillin resistant staphylococcus aureus, MRSA) and Gram negative (Escherichia coli, E.

(E)-4-Chloro-N-(2,4,6-trimethyl-benzyl-idene)aniline.

In the title compound, C(16)H(16)ClN, the dihedral angle between the benzene rings is 24.61 (13)°. In the crystal, only van der Waals inter-actions occur between neighbouring mol-ecules.

2-Meth-oxy-naphthalene-1,4-dione.

The title compound, C(11)H(8)O(3), was isolated from Impatiens balsamina plants (balsam, LIB) grown in our laboratory. The two six-membered rings of the naphthalene-1,4-dione unit are coplanar [maximum deviation = 0.009 (1) Å].

9a-Hy-droxy-3,8a-dimethyl-5-methyl-ene-4,4a,5,6,9,9a-hexa-hydro-naphtho-[2,3-b]furan-2(8aH)-one.

The title compound, C(15)H(18)O(3), was isolated from Lacta-rius piperatus (Fr.) S. F.

Targeted antimicrobial moieties (WO2010080819): patent evaluation.

The verification of refined variants of already existing medicines proved to be a breakthrough for antibiotic research. However, resistance to old and newer antibiotics among microbacillary pathogens is evolving quickly. Drug-resistant pathogens have become an important economic burden for patients.

(2R,4R)-3-(tert-But-oxy-carbon-yl)-2-(3-chloro-phen-yl)-1,3-thia-zolidine-4-carb-oxy-lic acid monohydrate.

In the title compound, C(15)H(18)ClNO(4)S·H(2)O, the thia-zolidine ring displays a half-chair conformation. In the crystal, the water mol-ecules are linked to the organic acid mol-ecules via inter-molecular O-H⋯O hydrogen bonds.

3-(tert-But-oxy-carbon-yl)-2-(4-chloro-phen-yl)-1,3-thia-zolidine-4-carb-oxy-lic acid.

In the title compound, C(15)H(18)ClNO(4)S, the thia-zolidine ring adopts a twisted conformation about the S-C(methyl-ene) bond. The dihedral angle between the five- and six-membered rings is 77.2 (3)°.

Synthesis, structure and structure-activity relationship analysis of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives as potential antibacterial agents.

Nine 2-arylthiazolidine-4-carboxylic acid derivatives and nine 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives were synthesized to screen for their antibacterial activities. Compounds 5, 14-18 were first reported. Their chemical structures were clearly determined by (1)H NMR, (13)C NMR, ESI mass spectra and elemental analyses, coupled with one selected single-crystal structure.

Methyleneimidazoline complexes of iridium, rhodium, and palladium from selective C(sp3)-H bond activation.

Palladium, iridium, and rhodium complexes of 2-methyleneimidazolines have been synthesized by selective phosphine-assisted activation of the 2-methyl C-H bonds in 2-methylimidazolium compounds. Metallacycles of various sizes were obtained in the reaction of phosphine-tethered 2-methylimidazolium compounds and [{M(cod)X}(2)] (M = Rh or Ir; cod = 1,5-cyclooctadiene; X = alkoxyl or Cl). Representative complexes were characterized by X-ray crystallography.

Synthesis, antiproliferative activity, and structure-activity relationships of 3-aryl-1H-quinolin-4-ones.

The antiproliferative activities of 36 3-aryl-1H-quinolin-4-ones were determined against two cancer cell lines (Hep G2 and KB) in vitro. The results indicate that most of these compounds show good cytotoxic activity against human cancer cell lines, but no cytotoxicity against a human normal cell line (L02). The positive control compounds genistein and 5-fluorouracil show no selectivity at inhibiting the growth of the above three cell lines.

[Mechanical property analysis of polyethylene fiber reinforced polymethyl methacylate].

Objective: To investigate if the Ribbond polyethylene fiber has the effect of reinforcing polymethyl methacylate.

Methods: 28 specimens were fabricated and divided into 3 groups: group of chemical-cured PMMA, group of chemical-cured PMMA reinforced by stainless steel wire and group of chemical-cured PMMA reinforced by Ribbond polyethylene fiber. A three-point bending test was used to measure the flexural strength and flexural modulus of specimens.