Applicability and applications of alternative TOFD techniques.

Ultrasonic time-of-flight diffraction (TOFD) technique is applied to non-destructive testing in engineering, but the dead zone influences its applicable range. Alternative TOFD techniques adopt the indirect diffracted waves having long propagation times to decouple from the lateral wave and detect near-surface defects. It should be noted that the applicability of these diffracted waves varies with parameter conditions employed for detection, e.

[Retracted] LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression.

[This retracts the article DOI: 10.3892/ol.2022.

Molecular classification of geriatric breast cancer displays distinct senescent subgroups of prognostic significance.

Breast cancer in the elderly presents distinct biological characteristics and clinical treatment responses compared with cancer in younger patients. Comprehensive Geriatric Assessment is recommended for evaluating treatment efficacy in elderly cancer patients based on physiological classification. However, research on molecular classification in older cancer patients remains insufficient.

ZC3H12A inhibits tumor growth and metastasis of breast cancer under hypoxic condition via the inactivation of IL-17 signaling pathway.

Hypoxia is a major contributor to tumor microenvironment (TME) and metastasis in most solid tumors. We seek to screen hypoxia-related genes affecting metastasis in breast cancer and to reveal relative potential regulatory pathway. Based on gene expression profiling of GSE17188 dataset, differential expressed genes (DEGs) were identified between highly metastatic breast cancer cells under hypoxia and samples under normoxia.

LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression.

Breast cancer (BC) is a malignant disease and the most commonly diagnosed cancer in women. Numerous studies have previously verified the important role of long non-coding RNAs in a number of biological processes in BC. In the present study, analysis of The Cancer Genome Atlas database and reverse transcription-quantitative PCR demonstrated that LOC102724163 expression levels were significantly upregulated in BC tissues compared to matched adjacent normal tissues and were associated with an unfavorable prognosis in patients with BC.

A Competing Endogenous RNA Network Reveals Novel lncRNA, miRNA and mRNA Biomarkers With Diagnostic and Prognostic Value for Early Breast Cancer.

Background: This study aims to reveal early breast cancer (BC) specific competing endogenous RNA (ceRNA) network through the expression profiles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and mRNAs.

Methods: Based on The Cancer Genome Atlas (TCGA), we obtained the differentially expressed mRNAs, miRNAs, and lncRNAs (DEmRNAs, DEmiRNAs and DElncRNAs) between early BC and normal samples. The lncRNA-miRNA-mRNA interaction network was constructed using Cytoscape.

Identification and validation of a combined hypoxia and immune index for triple-negative breast cancer.

The interaction between hypoxia and immune status has been confirmed in various cancer settings, and corresponding treatments have been investigated. However, reliable biomarkers are needed for individual treatment, so we sought to develop a novel scoring system based on hypoxia and immune status. Prognostic hypoxia-immune status-related signatures of patients with triple-negative breast cancer (TNBC) were identified in The Cancer Genome Atlas (TCGA) (N = 158), Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) (N = 297), and GSE58812 (N = 107).

Combined quantitative evaluation on early-stage fatigue damage of coarse-grained austenite stainless steel based on EBSD and ultrasonic technique.

The elastic anisotropy and heterogeneity effects of coarse-grained austenite on ultrasonic propagation significantly undermine the effectiveness of ultrasonic property-based fatigue damage evaluation. A discrete method based on electron backscatter diffraction (EBSD) was proposed to decouple the effects between coarse-grained structure and fatigue damage. An orientation-based damage index, local misorientation (M), was extracted and macroscopic and microscopic plastic deformations were characterized.

Ultrasonic characterization of thermal barrier coatings porosity through BP neural network optimizing Gaussian process regression algorithm.

Porosity is an integral part of thermal barrier coatings (TBCs) and is required to provide thermal insulation and to accommodate operational thermal stresses. Accurate characterization of the TBCs porosity is difficult due to the complex pore morphology and ultra-thin coating thickness. In this paper, a BP neural network optimizing Gaussian process regression (GPR) algorithm, termed BP-GPR, is presented to characterize the TBCs porosity based on a constructed ultrasonic reflection coefficient amplitude spectrum (URCAS).

Safflower polysaccharide inhibits the proliferation and metastasis of MCF-7 breast cancer cell.

Breast cancer accounts for 22.9% of all types of cancer in females worldwide. Safflower polysaccharide (SPS) is an active fraction purified from safflower petals (Carthamus tinctorius L).

Modeling of ultrasonic propagation in heavy-walled centrifugally cast austenitic stainless steel based on EBSD analysis.

The ultrasonic inspection of heavy-walled centrifugally cast austenitic stainless steel (CCASS) is challenging due to the complex metallurgical structure. Numerical modeling could provide quantitative information on ultrasonic propagation and plays an important role in developing advanced and reliable ultrasonic inspection techniques. But the fundamental obstacle is the accurate description of the complex metallurgical structure.

Ultrasonic characterization of thermally grown oxide in thermal barrier coating by reflection coefficient amplitude spectrum.

The thermally grown oxide (TGO) growth at the interface of ceramic coating/bond coating in thermal barrier coatings (TBCs) was evaluated by ultrasonic reflection coefficient amplitude spectrum (URCAS). A theoretical analysis was performed about the influence of acoustic impedance match relationship between the ceramic coating and its adjacent media on URCAS. The immersion ultrasonic narrow pulse echo method was carried out on the TBC specimen before and after oxidation under 1050°C×1h for 15cycles.

Effects of promethazine or dexamethasone pretreatment on mivacurium-induced histamine release in children.

Objective: To determine the effects of pretreatment with either promethazine or dexamethasone on mivacurium-induced histamine release in children.

Methods: Eighty ASA I-II children (4-10 years of age) scheduled for tonsillectomy and/or adenoidectomy were randomly divided into 4 groups (n = 20 per group) designated as either the rocuronium, mivacurium, dexamethasone (DXM), or promethazine group. Children in the DXM and promethazine groups were treated separately with intramuscular DXM 0.