External auditory canal cholesteatoma: staging and treatment strategies.

Objective: To investigate clinical staging systems and appropriate treatment strategies for external auditory canal cholesteatoma (EACC).

Methods: We performed comparative analysis of the features of several staging schemes (Holt, Naim, Shin, Chang, Kaneda, Hn, and He) of EACC; retrospective analysis of the clinical data of 44 patients with primary EACC, and analyzed the prognosis.

Results: He's staging system (2019) was found to be particularly clear and practical.

The role of S100A8 and S100A9 in external auditory canal cholesteatoma.

Background: Studies indicated that diverse cellular mechanisms including epithelial migration and hyper-proliferation, inflammatory responses, and enzymatic bone erosion were involved in the pathogenesis of cholesteatoma. S100A8 and S100A9, which are Ca2+-binding proteins belonging to the S100 family, can trigger the signaling pathways involved in the inflammatory processes, and a variety of cellular processes includes cell cycle progression, proliferation, and cell migration. However, the role of S100A8 and S100A9 and their associated inflammation and other signaling pathways in cholesteatoma have not been investigated yet.

Causal relationships between gut microbiome and obstructive sleep apnea: a bi-directional Mendelian randomization.

Background: Previous studies have identified a clinical association between gut microbiota and Obstructive sleep apnea (OSA), but the potential causal relationship between the two has not been determined. Therefore, we aim to utilize Mendelian randomization (MR) to investigate the potential causal effects of gut microbiota on OSA and the impact of OSA on altering the composition of gut microbiota.

Methods: Bi-directional MR and replicated validation were utilized.

Exploring the impact of OSA on short-term survival in patients with AECOPD admitted to the ICU.

Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is characterized by a sudden worsening of chronic obstructive pulmonary disease (COPD) symptoms, which significantly contributes to hospitalizations related to COPD symptoms. Previous research has mainly focused on the correlation between obstructive sleep apnea (OSA) and COPD. However, there were few studies that investigated the short-term mortality rate of AECOPD patients with or without OSA.

Microbiome and Th cytokines association in chronic rhinosinusitis with or without nasal polyp.

Objective: Chronic rhinosinusitis (CRS), a common disease in otorhinolaryngology, seriously affects the life quality of patients. The existing therapy has certain limitations, and it is very urgent to deeply explore the pathogenesis and classification of CRS. Microbiome and inflammation are considered the causes of CRS, but the precise roles and the associations between these two factors in the pathogenesis of CRS remain controversial.

[Hormone replacement therapy in perimenopausal women with chronic tinnitus].

To explore and analyze the effect and indication of hormone replacement therapy（HRT） in perimenopausal women with chronic tinnitus. The perimenopausal women with chronic tinnitus were divided into mild group and moderate to severe group according to Kupperman score of menopause, and then were divided into treatment group and untreated group according to whether they received MHT treatment or not. The serum 5-HT level, tinnitus handicap inventory （THI） and Pittsburgh sleep quality index （PSQI） were compared before and after treatment.

Primary external auditory canal cholesteatoma of 301 ears: a single-center study.

Purpose: Limited literature exists on primary external auditory canal (EAC) cholesteatoma (EACC). Here, we focus on the clinical features of this rare disease, especially the invasive patterns of lesion progression, through a large population study and present simple and practical staging.

Methods: In all, 276 patients (male 99; female 177; mean age 41.

Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals.

The hair cells that reside in the cochlear sensory epithelium are the fundamental sensory structures responsible for understanding the mechanical sound waves evoked in the environment. The intense damage to these sensory structures may result in permanent hearing loss. The present strategies to rehabilitate the hearing function include either hearing aids or cochlear implants that may recover the hearing capability of deaf patients to a limited extent.

Cholesteatoma debridement for primary external auditory canal cholesteatoma with non-extensive bone erosion.

External auditory canal (EAC) cholesteatoma (EACC) is rare and its treatment for different lesions has not yet been standardized. This study aimed to explore the clinical features of EACC with bone erosion, and to assess the curative effect of initial complete cholesteatoma debridement (ICCD). Clinical characteristics and prognosis of 41 ears were analyzed retrospectively.

Clinical analysis of pediatric primary external auditory canal cholesteatoma.

Objective: Pediatric primary external auditory canal cholesteatoma (EACC) is a rare disease. The present study aimed to explore the clinical features and prognosis of this disease.

Methods: Clinical data of 41 ears with pediatric primary EACC were collected, and the clinical characteristics and prognosis were analyzed in this retrospective study.

[The significance of keratinocyte in hyperproliferation of middle ear cholesteatoma].

Objective: In order to investigate the interaction between the cytokines and keratinocyte and determine the role of cytokines in hyperproliferative of chronic otitis media with cholesteatoma, we observe the expression of matrix metalloproteinase 9 (MMP9), vascular endothelial growth factor (VEGF), keratinocyte growth factor (KGF) and its receptor (KGFR) in middle ear cholesteatoma.

Method: We examined the expression of MMP9, VEGF, KGF, KGFR and Ki-67 by immunohistochemistry in 50 specimens from chronic otitis media with cholesteatoma and 15 specimens from the normal skin of external auditory meatus. Ki-67 as an evaluation of cholesteatoma proliferation markers were used to detect the keratinocyte proliferative activity.