Modulating N-Heterocyclic Microenvironment in β-Ketoenamine Covalent Organic Frameworks to Boost Overall Photosynthesis of HO.

Covalent Organic Frameworks (COFs) have emerged as promising platforms for photocatalytic synthesis of hydrogen peroxide (HO) due to their tunable chemical compositions and efficient catalytic functionalities. Inspired by the role of the microenvironment in enzyme catalysis, this study introduces various N-heterocyclic species into β-ketoenamine COFs (N-COFs, where N represents the number of nitrogen atoms in the N-heterocycle) to regulate the microenvironment around catalytic sites on acceptor-donor-acceptor (A-D-A) COFs foroverall HO photosynthesis in pure water. The N-COFs exhibit distinct HO photosynthetic rates following the number of nitrogen atoms sequence of N-COF > N-COF > N-COF > N-COF, with N-COF with triazine structure showing the highest HO generation rate (4881 µmol h g) and the decent solar-to-chemical conversion (SCC) efficiency (0.

Chemoenzymatic Synthesis of Highly O-Glycosylated MUC7 Glycopeptides for Probing Inhibitory Activity against Pseudomonas aeruginosa Biofilm Formation.

MUC7, a highly glycosylated protein in saliva and respiratory tract, plays potential roles in facilitating bacterial clearance and preventing microbial invasion. The complexity of glycan structures and multiplicity of glycosylation sites of MUC7 make it very difficult to explore accurate biofunctions against pathogens. Here, we report an efficiently convergent chemoenzymatic approach to firstly synthesize highly O-glycosylated MUC7 glycopeptides with nine glycosylation sites bearing various glycoforms via the combined use of hydrophobic tag-assisted liquid-phase peptide synthesis and enzymatic-catalyzed glycan elongation.

The MYB-related transcription factor family in rubber dandelion (Taraxacum kok-saghyz): An insight into a latex-predominant member, TkMYBR090.

MYB-related (MYBR) proteins play diverse roles in plant growth and development. However, the MYBR genes in Taraxacum kok-saghyz, a promising alternative source of natural rubber, a valuable biopolymer, remain scarcely investigated. Here, a total of 122 MYBR genes, namely TkMYBRs, were identified and classified into the groups of GARP-like, CCA1-like/R-R, and a heterogenous one in T.

Morphology and Electrical Properties of AC Electric-Field-Assisted Low-Density Polyethylene.

The direct current (DC) electrical properties of insulating polymers (e.g., low-density polyethylene, LDPE) are very important for the development of high-voltage direct current (HVDC) cables.

Decoding the Implications of Zinc in the Development and Therapy of Leukemia.

Zinc plays a central role in the hematological development. Therapeutic interventions with zinc are shown to improve the health status of patients with malignancies by stimulating the immune system and reducing side effects. Despite the abnormal zinc homeostasis in leukemia, the role and mechanisms of zinc signaling in leukemia development remain poorly understood.

Research Progress in the Molecular Mechanism of NLRP3 Inflammasome in Alzheimer's Disease and Regulation by Natural Plant Products.

Alzheimer's disease (AD) is a prominent neurodegenerative disorder affecting the central nervous system in the elderly. Current understanding of AD primarily centers on the gradual decline in cognitive and memory functions, believed to be influenced by factors including mitochondrial dysfunction, β-amyloid aggregation, and neuroinflammation. Emerging research indicates that neuroinflammation plays a significant role in the development of AD, with the inflammasome potentially mediating inflammatory responses that contribute to neurodegeneration.

Unlocking the Therapeutic Potential of Natural Products for Alzheimer's Disease.

Alzheimer's disease (AD) is a progressive neurodegenerative condition marked by memory loss and cognitive decline. With current treatments offering limited effectiveness, researchers are turning to natural products that can target various aspects of AD pathology. Clinically approved natural products, such as galantamine and huperzine A, have shown success in AD treatments.

The neuroprotective effects of cholecystokinin in the brain: antioxidant, anti-inflammatory, cognition, and synaptic plasticity.

Cholecystokinin (CCK) is a major neuropeptide in the brain that functions as a neurotransmitter, hormone, and growth factor. The peptide and its receptors are widely expressed in the brain. CCK signaling modulates synaptic plasticity and can improve or impair memory formation, depending on the brain areas studies and the receptor subtype activated.

Magnetic nanoparticle modified moss Biochar: A novel solution for effective removal of enrofloxacin from aquaculture water.

The presence of residual antibiotics in water constitutes a potential threat to aquatic environments. Therefore, designing environmentally friendly and efficient biochar adsorbents is crucial. Aquaculture by-product moss (bryophyte) was transformed into biochar, which can eliminate antibiotics from wastewater through adsorption.

HPV genotypes in invasive cervical cancer: prevalence, risk attribution, and optimized vaccine strategies in western China.

Background: Understanding the HPV genotype distribution in invasive cervical cancer (ICC) is essential for vaccine optimization. This study presents a comprehensive analysis of HPV genotypes in ICC tissues from patients in western China, with the aim of informing regional vaccine policy and prevention strategies.

Methods: DNA was extracted from 1,908 paraffin-embedded ICC samples, and 23 HPV genotypes were detected via PCR and reverse dot hybridization gene chip assays.

Hydrophilic/hydrophobic heterojunctions for enhanced photocatalytic hydrogen evolution via gas release dynamics.

Covalent-organic frameworks (COFs), characterized by their exceptional light absorption and ordered architecture, have emerged as potential candidates for photocatalytic hydrogen production. In this work, we discovered that the incorporation of fluorine into the sub-nanocavity of azine-linked COF (TF-COF) not only augments its hydrophobicity but also strengthens the interaction between Pt cocatalysts and COFs. In an effort to enhance photocatalytic water splitting efficiency, we integrated the hydrophobic TF-COF with the hydrophilic carbon nitride (CN) to construct a hydrophilic/hydrophobic heterojunction (CTF-x heterojunction).

Neural functional rehabilitation: exploring neuromuscular reconstruction technology advancements and challenges.

Neural machine interface technology is a pioneering approach that aims to address the complex challenges of neurological dysfunctions and disabilities resulting from conditions such as congenital disorders, traumatic injuries, and neurological diseases. Neural machine interface technology establishes direct connections with the brain or peripheral nervous system to restore impaired motor, sensory, and cognitive functions, significantly improving patients' quality of life. This review analyzes the chronological development and integration of various neural machine interface technologies, including regenerative peripheral nerve interfaces, targeted muscle and sensory reinnervation, agonist-antagonist myoneural interfaces, and brain-machine interfaces.

Periampullary Diffuse Large B-Cell Lymphoma Presenting as Acute Pancreatitis.

Periampullary malignancies are uncommon and encompass a wide variety of tumors. Early and accurate biopsy-proven diagnosis is important because different malignancy subtypes warrant different management and treatment plans. We present a unique and rare case of periampullary lymphoma, initially presenting as acute pancreatitis.

Polyelectrolyte fabricated nanofiltration membrane with heterogeneously charged channels for high efficient cephalexin wastewater treatment.

Nanofiltration (NF) for treatments of pharmaceutical wastewater is a promising direction for water protection and resources recovery. Herein, a novel membrane with heterogeneously charged channels was constructed by modified layer-by-layer assembly methods. Within the well-designed pores, the polyanion structure excludes the cephalexin and the cationic structure slows down its diffusion, thereby rejections for cephalexin are improved.

FeO@MXene@PEI aerogel immobilized acetylcholinesterase for inhibitor screening from herbal plants.

Screening of acetylcholinesterase (AChE) inhibitors is a common strategy in drug discovery for treating Alzheimer's disease. Herein, AChE was immobilized onto magnetic polyethyleneimine-based MXene aerogels through both electrostatic interactions and covalent bonds, enabling its application in AChE activity assays and inhibitor screening of herbal plants. The composite was analyzed using a range of techniques, including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), and Zeta potential analysis, to gain insight into its chemical and physical properties.

Proteomic analysis and experimental validation reveal the blood-brain barrier protective of Huanshaodan in the treatment of SAMP8 mouse model of Alzheimer's disease.

Background: Huanshaodan (HSD) is a Chinese Herbal Compound which has a definite clinical effect on Alzheimer's disease (AD), however, the underlying mechanism remains unclear. The aim of this study is to preliminarily reveal the mechanism of HSD in the treatment of AD model of SAMP8 mice.

Methods: Chemical composition of HSD and its drug-containing serum were identified by Q-Orbitrap high resolution liquid mass spectrometry.

The root reinforcement on the slope under the condition of colonization of various herbaceous plants.

This study assessed root reinforcement on slopes influenced by various herbaceous species. The study examined the distribution, structural traits of these species, and their root systems, as well as their biomass. We established a quantitative model for evaluating root reinforcement at the soil interface influenced by different herbaceous colonizers.

Pan-genome and phylogenomic analyses highlight Hevea species delineation and rubber trait evolution.

The para rubber tree (Hevea brasiliensis) is the world's sole commercial source of natural rubber, a vital industrial raw material. However, the narrow genetic diversity of this crop poses challenges for rubber breeding. Here, we generate high-quality de novo genome assemblies for three H.

Huanshaodan regulates microglial glucose metabolism reprogramming to alleviate neuroinflammation in AD mice through mTOR/HIF-1α signaling pathway.

Abnormal glucose metabolism in microglial is closely associated with Alzheimer's disease (AD). Reprogramming of microglial glucose metabolism is centered on regulating the way in which microglial metabolize glucose to alter microglial function. Therefore, reprogramming microglial glucose metabolism is considered as a therapeutic strategy for AD.

Real-world effectiveness and safety of Baloxavir Marboxil or Oseltamivir in outpatients with uncomplicated influenza A: an ambispective, observational, multi-center study.

Introduction: Baloxavir Marboxil is a per oral small-molecule antiviral for the treatment of influenza. While the efficacy and safety of Baloxavir Marboxil have been thoroughly characterized across an extensive clinical trial, studies on the effectiveness of Baloxavir Marboxil in a real-world setting are still scarce.

Methods: We conducted an ambispective, observational, multi-center study that enrolled uncomplicated in-fluenza outpatients treated with Baloxavir Marboxil or Oseltamivir in East China.

Synergistic Improvement of BiI and In on Thermoelectric Properties of Zone-Melted -Type BiTeSe.

Bismuth telluride (BiTe) is the only commercial thermoelectric material so far, and it is also the best thermoelectric material with the best performance at room temperature. However, up to now, the value of -type materials used on a large scale is only about 1.0; this makes the thermoelectric conversion efficiency of thermoelectric devices and thermoelectric applications stagnant.