Publications by authors named "Zhong-zheng Jia"
Rationale And Objectives: To investigate the potential of T1-weighted imaging (T1WI)-based hippocampal radiomics as imaging markers for the diagnosis of Alzheimer's disease (AD) and their efficacy in discriminating between mild cognitive impairment (MCI) and dementia in AD.
Methods: A total of 126 AD patients underwent T1WI-based magnetic resonance imaging (MRI) examinations, along with 108 age-sex-matched healthy controls (HC). This was a retrospective, single-center study conducted from November 2021 to February 2023.
Background: Accurate segmentation of neonatal brain tissues and structures is crucial for studying normal development and diagnosing early neurodevelopmental disorders. However, there is a lack of an end-to-end pipeline for automated segmentation and imaging analysis of the normal and abnormal neonatal brain.
Objective: To develop and validate a deep learning-based pipeline for neonatal brain segmentation and analysis of structural magnetic resonance images (MRI).
DL-3-n-butylphthalide (NBP)-a compound isolated from Apium graveolens seeds-is protective against brain ischemia via various mechanisms in humans and has been approved for treatment of acute ischemic stroke. NBP has shown recent potential as a treatment for Parkinson's disease. However, the underlying mechanism of action of NBP remains poorly understood.
View Article and Find Full Text PDFObjective: To explore whether magnetic susceptibility value (MSV) and radiomics features of the nigrostriatal system could be used as imaging markers for diagnosing Parkinson's disease (PD) and its related cognitive impairment (CI).
Methods: A total of 104 PD patients and 45 age-sex-matched healthy controls (HCs) underwent quantitative susceptibility mapping (QSM). The former completed Hoehn-Yahr Stage and Montreal Cognitive Assessment (MoCA).
Objectives: To investigate whether glioma isocitrate dehydrogenase () 1 mutation and vascular endothelial growth factor () expression can be estimated by histogram analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).
Methods: Chinese Glioma Genome Atlas (CGGA) database was wined for differential expression of in gliomas with different genotypes. The expression and genotypes of 56 glioma samples in our hospital were assessed by immunohistochemistry.
Purpose: The study aimed to investigate whether isocitrate dehydrogenase 1 (IDH1) mutation status in gliomas can be estimated by volume-based histogram analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).
Materials And Methods: Preoperative DCE-MRI data of 85 pathologically confirmed glioma patients including 33 carrying IDH1 mutant type (IDH1) and 52 with IDH1 wildtype (IDH1) were reviewed in a retrospective approach. Regions of interest (ROI) covering entire tumor volume were manually delineated using O.
Rationale And Objectives: This study aimed to investigate whether volume transfer constant (K) and volume of extravascular extracellular space per unit volume of tissue (V) derived from dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) could quantitatively assess the tumor proliferation index (Ki-67) of gliomas noninvasively.
Materials And Methods: The preoperative DCE MRI data of 69 patients with pathologically confirmed glioma (28, 8, and 33 cases in grades Ⅱ, Ⅲ, and Ⅳ) were retrospectively reviewed. The maximal K and V were measured in the tumor body.
Purpose: Perfusion computed tomography (PCT) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provide independent measurements of biomarkers related to tumor perfusion. The aim of this study was to compare the two techniques in assessing glioblastoma microvasculature.
Materials And Methods: Twenty-five patients diagnosed with glioblastoma (14 males and 11 females; 51±11years old, ranging from 33 to 70 years) were includede in this prospective study.
Article Synopsis
- - This study aimed to assess the immature microvascular density (MVD) of brain gliomas using dynamic contrast-enhanced MRI (DCE-MRI) to provide a noninvasive analysis of tumor characteristics.
- - The research included 57 patients with varying grades of brain gliomas, and significant differences in K(trans), Ve, and CD105-MVD were found between low-grade and high-grade gliomas, indicating that these measurements can reflect tumor severity.
- - Results revealed that K(trans) and Ve levels were lower in lower-grade tumors and were positively correlated with CD105-MVD in high-grade gliomas, suggesting DCE-MRI is crucial for evaluating glioma aggression.
Background: The degree of pathological microvascular proliferation is an important element in evaluation of the astrocytoma grade. This study was aimed to quantitatively assess the microvascular permeability of brain astrocytoma with the volume transfer constant (K(trans)) and volume of extravascular extracellular space per unit volume of tissue (Ve) from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and to evaluate the effectiveness of the K(trans) and Ve in the grading of astrocytoma.
Methods: The highest values of the K(trans) and Ve of 67 patients with astrocytoma (27 with grade II, 12 with grade III, and 28 with grade IV) were obtained.
[Kinematics of the triangular fibrocartilage complex during forearm rotation in vivo].
Zhonghua Wai Ke Za Zhi
November 2009
Objective: To investigate three-dimensional kinematics of the superficial and deep portion of triangular fibrocartilage complex (TFCC) in different parts of the forearm rotation.
Methods: Six wrists of 6 volunteers were used to obtain CT scans at different positions of the wrist. The wrists were scanned from 90 degrees of pronation to 90 degrees of supination at an interval of 30 degrees.
Objective: To evaluate the value of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in identification of tumor element and grading of brain astrocytoma.
Methods: Thirty-three patients with histologically confirmed astrocytoma underwent diffusion weighted imaging (DWI), diffusion tensor imaging (DTI), and conventional MRI before operation. The values of ADC and FA of different regions in the same tumor and of astrocytoma of different grades were measured and compared.