[Protective effects of glycyl-glutamine dipeptide supplement on the heart function in burn rats].

Objective: To investigate the protective effects of glycyl-glutamine dipeptide supplement on the function of myocardial dynamics in severely burned rats, and to explore its mechanism.

Methods: One hundred and thirty-six Wistar rats were randomly divided into five groups: i. e, control group (C, n = 8, without burns), burn group (B, n = 32), Gln group (Gln, n = 32), Gly group (Gly, n = 32) and Gly-Gln group (Gly-Gln, n = 32).

[Analysis of the influence on the prognosis and safety of arginine in patients with severe trauma and burns--a multi-center randomized double blinded, placebo controlled, clinical trail in 86 patients].

Objective: To observe the influence on prognosis and possible side-effects of arginine in

Methods: Multi-center clinical trial, randomized double blinded patients with severe trauma and burns. and placebo control methods were employed in the study. Eighty-six patients with severe trauma and burns were randomly divided into control (C, n = 45) and arginine treatment (Arg, n = 41) groups.

[Effects of glutamine given through different avenues on intestine mucosal barrier function in burned rats].

Objective: To observe the effect of glutamine given through different avenues on intestine mucosal barrier damage induced by severe burn injury.

Methods: One hundred and sixty Wistar rats were randomly divided into four groups: namely normal control (C group), burned control (B group), parenteral nutrition with glutamine (PN+GLN group) and enteral nutrition with glutamine (EN+GLN group). Rats in B group, PN+GLN group, and EN+GLN group were subjected to 30% total body surface area (TBSA) full-thickness burn injury.

[Effects of glutamine granules on immunofunction in trauma patients: a double-blind randomized controlled, multi-center clinical trail with 120 patients].

Objective: To evaluate the effect of glutamine granules on immunofunction in severe burns and trauma patients.

Methods: One hundred and twenty patients with severe burns, multiple trauma and post operation who met the requirements of the protocol joined this double-blind randomized controlled, multi-center clinical trail. Patients were randomly divided into two groups: placebo control group (P group, 60 patients) and glutamine granules treatment group (GLN group, 60 patients).

[Comparative study on the influence of arginine hydrochloride and arginine acetate on the immune function and acid-base balance in rabbits with severe burns].

Objective: To investigate the influence of arginine hydrochloride and arginine acetate on the immune function and acid-base balance in rabbits with severe burns.

Methods: One hundred and ten flap-eared rabbits were used in the study, in which 8 served as normal control, while the rest were inflicted with 30% TBSA full thickness burn. All the rabbits were divided into 10 groups, i.

[Analysis of the therapeutic effect and the safety of glutamine granules per os in patients with severe burns and trauma].

Objective: To observe the therapeutic effect and possible side effects of glutamine granules per os in patients with trauma, burns and major operations.

Methods: Patients inflicted with severe burns, trauma and major operations were enrolled in the study. One hundred and twenty patients were randomly divided into two groups, 60 in control group (C) and 60 in glutamine group (Gln).

[Effects of glutamine granules on protein metabolism in trauma patients].

Objective: To evaluate the effect of glutamine granules on protein metabolism in severe burns and trauma patients.

Methods: 120 patients with severe burns, multiple trauma and post operation who met the requirements of the protocol joined this double-blind randomized controlled, multi-center clinical trail. Patients were randomly divided into two groups: placebo control group (P group, 60 patients) and glutamine granules treatment group (GLN group, 60 patients).

[Effects of enteral supplementation with glutamine on mitochondria respiratory function of intestinal epithelium in burned rats].

Objective: To investigate the effects of enteral supplementation with glutamine on mitochondria respiratory function of intestinal epithelium in burned rats.

Methods: Wistar rats inflicted with 30% total body surface area (TBSA) full thickness thermal injury were randomly divided into three groups, i.e.

[Experimental study on the effects of intestinal trefoil factor on intestinal epithelial proliferation and its signal transduction mechanism].

Objective: To explore the effects of intestinal trefoil factor (ITF) on intestinal epithelial proliferation and its possible signal transduction mechanism.

Methods: 1). The intestinal epithelial cytoplasmic membrane was isolated and harvested from Wistar rats, and it was treated with various doses of ITF in the concentration of 0.

[Influence of glucagon-like peptide-2 on the proliferation of the intestinal mucosal cells in scalded rats].

Objective: To explore the influence of glucagon-like peptide-2 (GLP-2) on the proliferation of the intestinal mucosal cells in scalded rats.

Methods: Fifty-five Wistar rats were employed in the study and were randomly divided into normal control (C), simple scald (S) and scald with GLP-2 treatment (G) groups. The rats in G group received GLP-2 introperitoneally in a dose of 200 micro g/kg two times a day.