Publications by authors named "Zhong-xun Yu"
LASSO-derived nomogram for early identification of pediatric monogenic lupus.
World J Pediatr
November 2024
Background: Monogenic lupus is defined as systemic lupus erythematosus (SLE)/SLE-like patients with either dominantly or recessively inherited pathogenic variants in a single gene with high penetrance. However, because the clinical phenotype of monogenic SLE is extensive and overlaps with that of classical SLE, it causes a delay in diagnosis and treatment. Currently, there is a lack of early identification models for clinical practitioners to provide early clues for recognition.
View Article and Find Full Text PDFArticle Synopsis
- - Aicardi-Goutieres syndrome (AGS) is a challenging inflammatory disorder often leading to high mortality rates, with limited research data specifically from China, highlighting the need for better understanding its clinical presentation and diagnostic criteria.
- - In a study of 23 Chinese AGS patients, the majority (82.6%) experienced symptoms before age 3, with common neurological issues and skin manifestations; notable findings included intellectual and language disabilities, and various dysfunctions such as liver and thyroid issues.
- - Elevated expression of interferon-stimulated genes was observed, suggesting a systemic nature of AGS, with diagnosis recommended for early-onset patients showing specific symptoms, as exemplified by one recorded death in the study.
In this study, the self-assembly behavior of polyelectrolyte (PE) diblock copolymers in solutions containing mixtures of monovalent and multivalent counterions was investigated using molecular dynamics simulation. The properties of the assembled micelles and counterion condensations at different charge fractions of multivalent ions have been discussed. The bridging effect of multivalent ions induces the electrostatic correlations of the PE chains, leading to the fusion of large micelles and the formation of bulky aggregates.
View Article and Find Full Text PDFToward a better understanding of type I interferonopathies: a brief summary, update and beyond.
World J Pediatr
February 2020
Backgrounds: Type I interferonopathy is a group of autoinflammatory disorders associated with prominent enhanced type I interferon signaling. The mechanisms are complex, and the clinical phenotypes are diverse. This review briefly summarized the recent progresses of type I interferonopathy focusing on the clinical and molecular features, pathogeneses, diagnoses and potential therapies.
View Article and Find Full Text PDFCurrent perspectives on pancreatic serous cystic neoplasms: Diagnosis, management and beyond.
World J Gastrointest Surg
March 2016
Article Synopsis
- Serous cystic neoplasms (SCNs) are rare, benign pancreatic lesions that make up about 16% of pancreatic cysts and are often found incidentally since they usually don't cause symptoms.
- Although SCNs carry a low risk of cancer, they can lead to anxiety for patients and result in costly medical investigations.
- The review offers an overview of SCNs, including their background, diagnostic approaches such as clinical features and imaging studies, and suggests management strategies to improve patient quality of life.
Effects of angiotensin II and losartan on the growth and proliferation of hepatic stellate cells.
Di Yi Jun Yi Da Xue Xue Bao
March 2003
Objective: To investigate the effects of angiotensin II (AngII) and AT1a blocker losartan on growth and proliferation of rat hepatic stellate cells (HSCs).
Methods: Rat HSCs were isolated, cultured and identified, followed by incubation with AngII or losartan at different concentrations. The cell growth and proliferation were assessed via cell counting and MTT assay, and the effects of the agents on HSC DNA synthesis evaluated by way of (3)H-thymidine incorporation ((3)H-TDR).