[Impact of ecological protection construction on schistosomiasis transmission of Qionghai Lake wetland in Xichang City].

Objective: To understand the impact of Qionghai Lake wetland ecological protection construction on the prevalence of schistosomiasis, so as to provide the evidence for formulating the strategies for schistosomiasis control and prevention.

Methods: A retrospective survey of the construction of Qionghai Lake wetland was performed, and eleven villages around the wetland were surveyed for schistosomiasis endemic situation. The influence of the wetland project on the schistosomiasis prevalence and Oncomelania hupensis snail status were investigated.

Determination of Earthy-musty Odorous Compounds in Drinking Water by Vortex Assisted Dispersive Liquid-Liquid Microextraction Combined with Gas Chromatography Tandem Mass Spectrometry.

A new method was developed for the determination of eight earthy-musty compounds in drinking water by gas chromatography tandem mass spectrometry (GC-MS/MS) combined with dispersive liquid-liquid microextraction (DLLME). In this work, the type and volume of extraction solvent and dispersion agent, and the amount of NaCl were optimized; the linearity, detection limit, recovery and precision of method were investigated. The results indicated that the target analytes were in the range of 0.

Panax Notoginseng flower saponins (PNFS) inhibit LPS-stimulated NO overproduction and iNOS gene overexpression via the suppression of TLR4-mediated MAPK/NF-kappa B signaling pathways in RAW264.7 macrophages.

Background: Panax Notoginseng flower saponins (PNFS) are the main active component of Panax notoginseng (Burk) F. H. Chen flower bud (PNF) and possess significant anti-inflammatory efficacy.

Impulse oscillometry for leukotriene D4 inhalation challenge in asthma.

Background: The value of impulse oscillometry (IOS) for bronchial provocation testing is poorly defined. We investigated the positive threshold derived from the parameters and diagnostic power of IOS for asthma with the leukotriene D(4) bronchial provocation test.

Methods: We enrolled 62 subjects with asthma and 21 healthy subjects.

[Determination of doxepin in whole blood by SPE-LC-MS/MS].

Objective: To develop a method of SPE-LC-MS/MS for the determination of doxepin in whole blood.

Methods: After solid phase extraction, the samples were identified by LC-MS/MS. Positive ion electrospray ionization mode and multiple reaction monitoring (MRM) mode was selected.

[Simultaneous determination of trihexyphenidyl, chlorpromazine and clozapine in blood by GC-MS].

Objective: To develop a method to measure trihexyphenidyl, chlorpromazine and clozapine in human blood with GC-MS.

Methods: The specimens were alkalized (pH > 10) and extracted with V (benzene):V(ethyl acetate) = 1:1, and qualitatively analyzed using GC-MS-Full Scan with internal standard SKF525A. The specimens were alkalized (pH > 10) and extracted with V(benzene):V(ethyl acetate) = 1:1, and quantitatively analyzed using GC-MS-SIM with internal standard diazepam-d5.