Publications by authors named "Zhong-lan Su"
Background: The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads to Akt phosphorylation at Ser-473, which is important for the carcinogenic effects of excessive sun exposure. The present study investigated the underlying mechanism of Akt Ser-473 phosphorylation by UVB radiation.
Results: We found that DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and mammalian target of rapamycin (mTOR) complex 2 (mTORC2) were both required for UVB-induced Akt Ser-473 phosphorylation in keratinocytes.
[Epithelioid hemangioma: a clinicopathologic analysis of 7 cases].
Zhonghua Bing Li Xue Za Zhi
September 2013
Article Synopsis
- The study focuses on the clinicopathologic features and diagnostic aspects of epithelioid hemangioma, analyzing 7 cases from skin, bone, and venous vessels.
- Patients ranged from 14 to 54 years old, presenting with various symptoms, including erythematous nodules on the skin and osteolytic lesions in bones; the tumors exhibited distinct morphological characteristics.
- Epithelioid hemangioma is a rare benign tumor with similar presentations to other conditions, but it typically shows no recurrence or metastasis after treatment, making it curable.
We demonstrate here that a relative low dose of perifosine significantly enhanced UVB-induced apoptosis in skin cells (keratinocytes and fibroblasts), associated with a significant increase of reactive oxygen species (ROS) and ceramide production as well as multiple perturbations of diverse cell signaling pathways, shifting to a significant pro-apoptosis outcomes. Perifosine inhibited UVB-induced pro-survival Akt/mammalian target of rapamycin (mTOR) and ERK activation, while facilitating pro-apoptotic AMP-activated protein kinas (AMPK), c-Jun-NH(2)-kinase (JNK), and p53 activation; these signaling changes together promoted a striking increase in skin cell apoptosis and a significantly reduced amount of DNA damages. Our results suggest that perifosine may represent a novel skin cancer prevention strategy.
View Article and Find Full Text PDFIncreasing ceramides sensitizes genistein-induced melanoma cell apoptosis and growth inhibition.
Biochem Biophys Res Commun
May 2012
The aim of the current study is to investigate the effect of ceramides on genistein-induced anti-melanoma effects in vitro. We found that exogenously added cell-permeable short-chain ceramides (C6) dramatically enhanced genistein-induced growth inhibition and apoptosis in cultured melanoma cells. Genistein treatment only induced a moderate intracellular ceramides accumulation in B16 melanoma cells.
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