Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer.

Lactate has been observed to fuel TCA cycle and is associated with cancer progression in human lung cancer, the leading cause of cancer deaths worldwide, but the effect of lactate on lung cancer metabolism is rarely reported. In this study, disordered metabolism in non-small cell lung cancer was demonstrated by increased G6PD and SDHA protein levels immunofluorescence, and up-regulated lactate dehydrogenase was found to be associated with poor prognosis. Then flow cytometry and Seahorse XFe analyzer were utilized to detect the effect of lactate on glycolysis and mitochondrial function in non-small cell lung cancer cells.

Disseminated Nocardia infection with a lesion occupying the intracranial space complicated with coma: a case report.

Background: Disseminated Nocardia infection is a disease that is easily overlooked in patients with lesions occupying the intracranial space complicated with coma. Early diagnosis and treatment are crucial.

Case Presentation: A 65-year-old man was admitted to the First Affiliated Hospital of Zhejiang University in October 2018 with weakness in the right limbs for 3 days and altered consciousness for 1 day.

Rational Design of β-sheet Peptides with Self-Assembly into Nanofibres on Remineralisation of Initial Caries Lesions.

Objective: To explore the self-assembly and gelation properties of synthetic peptides, and their efficacy on hydroxyapatite (HAP) nucleation and in situ remineralisation of initial caries lesions.

Methods: Mass spectrometry and reversed-phase high performance liquid chromatography (RPHPLC) were used to confirm the successful synthesis of peptides. Their self-assembly properties and conformation stability were evaluated using circular dichroism (CD) spectroscopy and Fourier-transform infrared spectroscopy (FTIR).

Upon designing carboxyl methylcellulose and chitosan-derived nanostructured sorbents for efficient removal of Cd(II) and Cr(VI) from water.

Considering that the hazardous heavy metal ions like Cd(II) and Cr(VI) are widely present in the environment, nowadays employing easy-to-handle adsorption-oriented processes are feasible choices towards efficient remediation of Cd(II) and Cr(VI) from aqueous systems. Herein we developed a novel amino-functionalized bead with cost-effectiveness, high sorption capacity and fast sorption kinetics to remove Cd(II) and Cr(VI) from aqueous solution. The carboxyl methylcellulose and chitosan-derived nanostructured sorbents synthesis were mainly through chitosan and dopamine self-polymerization, doped in sodium carboxymethyl cellulose, and glutaraldehyde cross-linking.

Performance enhanced electromagnetic wave absorber from controllable modification of natural plant fiber.

Short, surface rough carbon rods, which were derived from natural sisal fiber and went through two different modifications, with excellent electromagnetic wave absorption performance, were studied in this work for the first time. The structure-property relationship was clearly established here. It was shown that these green, cheap and easily obtained carbon rods with mass preparation possibility presented eye-catching absorbing behaviors towards electromagnetic wave.

A Clinical Application Study of Nanostructured Substrates for the Detection of Circulating Tumor Cells.

Background: Circulating tumor cell (CTC) isolation methods based on nanostructured substrates can be used to isolate tumor cells from peripheral blood. This study aimed to validate the clinical application of our method and determine the appropriate diagnostic critical value.

Methods: AFM was used to detect the surface roughness of nanostructured substrates.

Giant primary liposarcoma of the anterior mediastinum: A case report.

Rationale: Liposarcoma is a cancerous mesenchymal tumor and the most common soft-tissue sarcoma that starts in the adipose tissue. Liposarcoma is commonly found in lower extremities and retroperitoneum, but rarely occurs in the mediastinum.

Patient Concerns: A 63-year-old male was referred to our clinic with a 6-month history of chronic cough and dyspnea.

Systemic spread of tuberculosis after surgery for a splenic tuberculous abscess without postoperational antituberculosis treatment: a case report.

Solitary splenic tuberculosis (TB) is rare, with less than ten cases ever being reported. The diagnosis is established by the pathological analysis of a biopsy from a surgical operation or from a fine-needle aspiration sample. Manifestations of splenic TB include low-grade fever, weight loss, abdominal pain, and diarrhea.

[Association between serum matrix metalloproteinase-3 concentration and the promoter 5A/6A polymorphism in patients with coronary heart disease].

Objective: To investigate the association between serum matrix metalloproteinase-3(MMP-3) concentrations and the promoter 5A/6A polymorphism in patients with coronary heart disease (CHD).

Methods: The study enrolled 137 CHD patients and 106 control subjects without CHD. The diagnosis of both groups were confirmed by coronary artery angiography.