Heme induced progesterone-resistant profiling and promotion of endometriosis in vitro and in vivo.

Endometriosis is an estrogen-dependent, progesterone-resistant gynecological disease with an unknown pathogenesis. Compared to women without endometriosis, women with endometriosis have a remarkably high heme level in the peritoneal fluid. To further investigate the pathomechanisms of heme in endometriosis, we aimed to identify the dysregulated expression of heme-trafficking proteins, such as PGRMC1/2 that are also receptors that mediate the non-genomic responses to progesterone, and heme-degrading enzymes between ectopic endometrial stromal cells and their normal counterparts.

[The influence of heartbeat acceptance window settings on left ventricular function and perfusion parameters].

Objective: To evaluate the influence of heartbeat acceptance window settings on left ventricular function and perfusion parameters of the arrhythmia patients during gated myocardial perfusion imaging.

Methods: Twenty eight fibrillation patients were consecutively recruited to undergo myocardial perfusion SPECT. The Concurrent Imaging software was used to create 3 separate SPECT studies with heartbeat acceptance window of 20%, 60% and 100% respectively.

[Impact of patient motion on myocardial perfusion imaging with double-head SPECT and assessment of motion correction].

Objective: To investigate the impact of patient motion on myocardial perfusion imaging with double-head Single Photon Emission Computed Tomography (SPECT) and assess the effect of motion correction.

Methods: Twenty (20) patients were included in the study. Acquisitions were performed for all patients under the situations with or without body motion respectively.