Synopsis of recent research by authors named "Zhong-Ye Ma"
- Zhong-Ye Ma's recent research focuses primarily on the development and evaluation of PARP1 inhibitors as therapeutic options for triple-negative breast cancer (TNBC) and other cancers, emphasizing the potential of these inhibitors in patients with BRCA1/2 mutations and their mechanism of synthetic lethality.
- His work includes innovative approaches such as computational bioactivity fingerprinting to streamline scaffold hopping in drug discovery, potentially leading to the identification of new active compounds and addressing limitations of existing drugs like low solubility and permeability.
- Ma's findings highlight the critical importance of PARP1 in DNA repair mechanisms and tumor cell biology, outlining a pathway for the continued exploration and enhancement of PARP1-targeted therapies in oncology, supported by systematic evaluations of various virtual screening methods.
