Investigating the impact of STING pathway activation on breast cancer treatment outcomes: development and validation of a prognostic model.

Introduction: Breast cancer (BRCA) is a significant cause of cancer-associated mortality across the globe. Current therapeutic approaches face challenges such as drug resistance and metastasis. Immune signaling is triggered by chromosomal instability (CIN) generates misplaced DNA structures that activate the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, triggering.

Multimodal imaging study of lipemia retinalis with diabetic retinopathy: A case report.

Background: Lipemia retinalis (LR) is a rare disease related to hypertriglyceridemia. However, the symptoms of hypertriglyceridemia are insidious and difficult to detect without blood tests. The fundus is the only site where blood vessels can be observed directly.

Inhibition of Obtusifolin on retinal pigment epithelial cell growth under hypoxia.

Aim: To explore the effect of Obtusifolin on retinal pigment epithelial cell growth under hypoxia.

Methods: chemical hypoxia model of ARPE-19 cells was established using cobalt chloride (CoCl). Cell viability was tested by cell counting kit-8 (CCK-8) assay.

[Prevalence and causes of blindness and moderate and severe visual impairment among adults aged 50 years or above in Longyao County of Hebei Province:the China Nine-Province survey].

Objective: To investigate the prevalence and causes of blindness and moderate and severe visual impairment among adults aged ≥ 50 years in Longyao County, Hebei Province, China.

Methods: It was a population-based cross-section study.Geographically defined cluster sampling was used in randomly selecting 5527 individuals aged ≥ 50 years in Longyao County.