Publications by authors named "Zhong-Xu Chen"
The biological structure and function of the mammalian testis undergo important developmental changes during prepuberty and DNA methylation is dynamically regulated during testis development. In this study, we generated the first genome-wide DNA methylation profile of prepubertal porcine testis using methyl-DNA immunoprecipitation (MeDIP) combined with high-throughput sequencing (MeDIP-seq). Over 190 million high-quality reads were generated, containing 43642 CpG islands.
View Article and Find Full Text PDFThe binding sites of transcription factors (TFs) in upstream DNA regions are called transcription factor binding sites (TFBSs). TFBSs are important elements for regulating gene expression. To date, there have been few studies on the profiles of TFBSs in plants.
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- Pre-harvest sprouting (PHS) in wheat causes significant economic loss in high rainfall areas, and a study evaluated 717 Chinese landraces for PHS resistance using extensive genetic analysis techniques.
- The results showed that many landraces, especially white-grained ones, had better resistance to PHS, with geographical variations indicating higher resistance in southern China compared to northern regions.
- Three key genetic regions related to PHS resistance were identified, along with additional factors linked to grain color, suggesting a combination of natural and human selection contributed to enhancing PHS resistance in these wheat varieties.
As plenty of nonmodel plants are without genomic sequences, the combination of molecular technologies and the next generation sequencing (NGS) platform has led to a new approach to study the genetic variations of these plants. Software GATK, SOAPsnp, samtools, and others are often used to deal with the NGS data. In this study, BLAST was applied to call SNPs from 16 mixed functional gene's sequence data of polyploidy wheat.
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- * Researchers identified 2,407 transcription factors (TFs) in the wheat genome, classifying them into 63 families, representing about 2.22% of all wheat genes, which is lower than other cereal crops.
- * The study highlighted specific expression patterns of TFs related to various developmental stages and tissues, and established a comprehensive database called WheatTFDB to compile this information.