[Research progress on protective effects and mechanisms of garlic organosulfur compounds on respiratory diseases].

An increase in the number of smokers, severe air pollution and outbreak of respiratory infectious diseases have caused a sharp increase in patients with respiratory diseases, which seriously threatens the safety of human lives and properties. Garlic, as a medicine-food homology plant, is used as a medicine by its bulbs. It has various pharmacological effects such as anti-inflammation, anti-oxidation, blood lipid lowering, blood pressure lowering, and anti-bacterial effects.

Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment.

Diallyl trisulfide (DATS), a garlic organosulfide, has shown excellent chemopreventive potential. Cisplatin (DDP) is widely used to treat solid malignant tumors, but causing serious side effects. In the current study, we attempted to elucidate the chemopreventive mechanisms of DATS in human gastric cancer BGC-823 cells in vitro, and to investigate whether DATS could enhance the anti-tumor efficacy of DDP and improve quality of life in BGC-823 xenograft mice in vivo.

Immobilized enzyme reactors in HPLC and its application in inhibitor screening: A review.

This paper sets out to summarize the literatures based on immobilized enzyme bio-chromatography and its application in inhibitors screening in the last decade. In order to screen enzyme inhibitors from a mass of compounds in preliminary screening, multi-pore materials with good biocompatibility are used for the supports of immobilizing enzymes, and then the immobilized enzyme reactor applied as the immobilized enzyme stationary phase in HPLC. Therefore, a technology platform of high throughput screening is gradually established to screen the enzyme inhibitors as new anti-tumor drugs.