Publications by authors named "Zhong-Shu Yan"
Article Synopsis
- A clinical trial was conducted to explore if surgery for residual disease improves progression-free survival (PFS) in advanced GIST patients who are seeing positive results from imatinib mesylate (IM) treatment.
- Patients were divided into two groups: one received surgery to remove cancerous lesions followed by continued IM treatment, while the other group received IM alone.
- Although the trial ended early due to low enrollment, findings indicated a higher 2-year PFS in the surgery group compared to the IM-only group, suggesting surgery might benefit GIST patients, warranting further investigation.
Background: Laparoscopic colorectal surgery remains one of the most challenging techniques to learn.
Methods: The authors collected studies that have compared hand-assisted laparoscopic surgery (HALS) and open surgery for the treatment of colorectal disease over the past 17 years. Data of interest for HALS and open surgery were subjected to meta-analysis.
Laparoscopic versus open right hemicolectomy for colon cancer: a meta-analysis.
J Laparoendosc Adv Surg Tech A
January 2013
Objective: This meta-analysis was designed to assess the feasibility and safety of laparoscopic right hemicolectomy for colon cancer.
Research Design: A systematic search of the MEDLINE, EMBASE, and Cochrane databases identified 12 studies that met the inclusion criteria for data extraction. Publications that compared laparoscopic right hemicolectomy and open right hemicolectomy for treatment of colon cancer in the past 20 years were collected for review.
Background: The aim of this study was to investigate the safety and efficacy of the medial approach (MA) and the lateral approach (LA) in the treatment of colorectal disease.
Methods: Studies published since 1994 that compared MA versus LA in laparoscopic colorectal resection were collected. Data on conversion rate, operative time, blood loss, number of harvested lymph nodes, hospital stay, complications, mortality, rate of recurrence, and hospitalization costs for MA and LA were meta-analyzed using fixed-effect and random-effect models.
Background: This meta-analysis was designed to evaluate the necessity of indwelling gastrointestinal decompression after gastrectomy.
Methods: Medline, Embase, and the Cochrane Library were searched. We identified randomized controlled trials that compared individuals with or without gastrointestinal decompression after gastrectomy, and a meta-analysis was performed on data regarding the recovery time of gastrointestinal function, length of hospital stay, complications, and mortality using fixed effect and random effect models.
Background: Imatinib mesylate has been the standard therapeutic treatment for chronic myeloid leukemia, advanced and metastatic gastrointestinal stromal tumor (GIST). It is well tolerated with mild adverse effects. Gynecomastia development during the course of treatment has been rarely reported.
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