Publications by authors named "Zhong-Qing Jiang"
Autoimmune diseases are characterized by the body's immune system attacking its own cells, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS). In recent studies, regulatory B cells (Bregs), which play a vital role in maintaining peripheral tolerance and controlling persistent autoimmune diseases (ADs), have shown great potential in treating ADs. This review synthesizes the latest advancements in targeted therapies for ADs, with a particular emphasis on the subgroups, phenotypic markers, and signal pathways associated with Bregs.
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- Difficult-to-treat Rheumatoid arthritis (D2T RA) is defined by the lack of response to at least two different biologic drugs, leading to ongoing disease activity, prompting a systematic review of treatment options.
- The study reviewed 42 randomized controlled trials to evaluate the effectiveness and safety of various drugs, finding that tocilizumab, baricitinib, and olokizumab ranked highest in improving disease activity scores.
- The results suggest that tocilizumab, particularly at an 8 mg/4-week dosage, alongside rituximab, are effective and safe options for managing D2T RA, marking tocilizumab as a leading choice for treatment.
Rheumatoid arthritis (RA) is a complex autoimmune inflammatory rheumatic disease characterized by an imbalance between immunological reactivity and immune tolerance. Regulatory T cells (Tregs), which play a crucial role in controlling ongoing autoimmunity and maintaining peripheral tolerance, have shown great potential for the treatment of autoimmune inflammatory rheumatic diseases such as RA. This review aims to provide an updated summary of the latest insights into Treg-targeting techniques in RA.
View Article and Find Full Text PDFObjectives: The objective of this study was to determine the relationship between the levels of stress biomarkers in cord blood and pre-eclampsia (PE) in a hospital-based population of pregnant patients and evaluate the effects on pregnancy outcomes.
Design: This was an observational, case-control study. Participants/Materials, Setting, Methods: This case-control study included 282 patients with severe PE and 534 women with normal pregnancy.
Faba bean protein has good functionalities, but it is little used in the food industry. This study identified a challenge from unfavourable starch gelation when utilizing faba bean for producing protein-based emulsion gel foods, and developed processing methods to overcome that. Two types of protein-based emulsion gel foods, namely yogurt and tofu analogue products, were prepared.
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- Graphene nanomaterials, particularly graphene quantum dots (GQDs), show promise in biomedical applications due to their exceptional properties, but concerns exist regarding their potential adverse effects on biological systems.
- In vitro studies revealed that high dosages of GQDs hindered the maturation of mouse oocytes, causing issues like decreased polar body extrusion rates and damage to mitochondrial structures, likely due to DNA damage and reactive oxygen species accumulation.
- In vivo experiments indicated that while high GQD exposure during pregnancy affected fetal growth, it did not impact the long-term health or reproductive success of subsequent generations, suggesting a need for continued research on GQDs for safe medical use.
The course of protein-lipid co-oxidation was investigated in oil-in-water emulsions stabilized with proteins extracted from microwave-treated (MWT) and conventional thermal-treated (CTT) faba beans stored at 37°C for 7 days. Emulsions prepared with proteins from untreated (UT) faba beans and soy protein isolate (SP) were monitored for comparison. Lipid oxidation was detected through formation of primary and secondary oxidation products while protein oxidation was examined via tryptophan fluorescence degradation in interface and aqueous phase.
View Article and Find Full Text PDFObjective: To study the expression and significance of matriptase in different metastatic potential of human ovarian cancer cells.
Methods: High-metastatic human ovarian cancer cell HO8910PM and ovarian cancer cell HO8910 were collected.The ability of metastatic of the former was stronger than that of the latter.
We aimed to investigate the application of adipose-derived stromal cells in the treatment of stress urinary incontinence (SUI). Animal models of stress urinary incontinence were established with Sprague-Dawley female rats by complete cutting of the pudendal nerve. Rat adipose-derived stromal cells were isolated, cultured and successfully transplanted into animal models.
View Article and Find Full Text PDFBackground & Objective: Matrix metalloproteinase-9 (MMP-9) might plays an important role in regulating processes of tumor angiogenesis, invasion,and metastasis. The expression and clinical significance of MMP-9 in early invasive carcinoma of cervix was investigated.
Methods: Expression of MMP-9, microvessel density (MVD) labeled by CD(34) and proliferation index of cancer cells labeled by Ki-67 in 75 cases of early invasive carcinoma of cervix (ICC), 18 cases of cervical intraepithelial neoplasm (CIN), and 15 cases of normal cervical epithelium (NCE) were detected by immunohistochemistry SP method.