Publications by authors named "Zhong-Liu Wei"
Background: The prognostic impact of preoperative gamma-glutamyl transpeptidase to platelet ratio (GPR) levels in patients with solitary hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) following radical resection has not been established.
Aim: To examine the clinical utility of GPR for prognosis prediction in solitary HBV-related HCC patients.
Methods: A total of 1167 solitary HBV-related HCC patients were retrospectively analyzed.
The purpose of this investigation was to assess the diagnostic and prognostic significance of genes in hepatocellular carcinoma (HCC). The Student t-test was used to compare the expression level of between HCC and paraneoplastic tissues. Receiver operating characteristic curve (ROC) analysis was applied for diagnostic efficiency assessment.
View Article and Find Full Text PDFBackground: Hepatocellular carcinoma (HCC) was frequently considered as a kind of malignant tumor with a poor prognosis. Cyclin-dependent kinases (CDK) 4 was considered to be cell-cycle-related CDK gene. In this study, we explored the clinical significance of CDK4 in HCC patients.
View Article and Find Full Text PDFArticle Synopsis
- HMGA1 protein is linked to poor prognosis in hepatocellular carcinoma (HCC), as it influences cell growth, invasion, and apoptosis while showing higher levels in tumor tissue compared to adjacent normal tissue.
- Analysis from various databases revealed that high HMGA1 expression correlates with adverse clinicopathological features, alterations in cellular processes, and immune microenvironment changes.
- HMGA1 may serve as a valuable prognostic biomarker and a potential target for immunotherapy in HCC due to its impact on immune cell composition and tumor dynamics.
Background: Cytochrome P450 2C8 (CYP2C8) gene is one of the members of the cytochrome P450 enzymes (CYPs) gene family. The aim of this study was to reveal the function of CYP2C8 in hepatocellular carcinoma (HCC) and its effect on the sorafenib resistance.
Methods: Differential expression analysis in multiple HCC datasets all suggested that CYP2C8 expression was significantly decreased in HCC tissues, compared with para-carcinoma liver tissues.