Divalent oseltamivir analogues as potent influenza neuraminidase inhibitors.

A panel of divalent oseltamivir and guanidino oseltamivir analogues with esterification on the carboxyl acid group as potent inhibitors of influenza virus neuraminidase was prepared via click reaction. The primary structure activity relationship study demonstrated that appropriate distance between two oseltamivir monomers around 30 Å can crosslink two adjacent neuraminidase tetramers on the virion surface and result in highly effective NA inhibitors against three strains of influenza virus and H7N9 virus like particle. This strategy also provides a basis for the multivalent modification on oseltamivir.

[Combined Process of DNBF-O-GAC for Nitrogen and Phosphorus and Metabolite Advanced Removal].

To improve the quality of the tailings water from a wastewater treatment plant (WWTP), a denitrification biofilter (DNBF) with a composite filler composed of a new slow-release organic-carbon source (SOC-F), sponge iron, and activated carbon was tested. Studies were conducted in the combined process of DNBF-O-GAC to explore the efficiency of the advanced removal of nitrogen, phosphorus, and microbial metabolite by using synthetic effluent made from running water and chemicals. Corresponding comparative studies were conducted by using the secondary effluent from the WWTP.

[Preparation and Phosphorus Removal Mechanism of Highly Efficient Phosphorus Adsorbent Mg/Al-LDO].

Aiming at the problem of phosphorus removal in water, Mg/Al-layered double hydroxides (Mg/Al-LDHs) were synthesized via optimized constant pH co-precipitation method, and highly efficient phosphorus adsorbent Mg/Al-layered double oxide(Mg/Al-LDO) was obtained when it was calcined at high temperature. Based on the adsorption characteristics of phosphorus removal, the study combined Zeta potential, X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) to analyze the changes of isoelectric point, crystal structure and functional group before and after adsorption. In addition, Mg/Al-LDO of phosphorus adsorption mechanism was discussed.

[Feasibility of 3BER-S Process for the Deep Denitrification in Synch with the Removal of PAEs from Reclaimed Water].

In order to investigate the feasibility of deep denitrification and simultaneous removing phthalate esters (PAEs) in the process of reclaimed water treatment uses three-dimensional biofilm-electrode reactor coupled with sulfur autotrophic deep denitrification technology (3BER-S), the technological characteristics and mechanisms were analyzed based on determining the static adsorption capacity of biofilm cultured active carbon fillers in 3BER-S reactor together with the operation results of dynamic denitrification and simultaneous PAEs removing. The results showed that the average adsorption rates of DBP, DEHP were 85.84% and 97.

A Shortcut to the Optimization of Cellulase Production Using the Mutant Trichoderma reesei YC-108.

Trichoderma reesei YC-108, a strain isolated by a kind of newly invented plate was found to over produce cellulase and it was then used as a cellulase producer. To get the maximum amount of cellulase, the combination of the medium ingredients, which has a profound influence on metabolic pathway was optimized using response surface methodology. The optimum composition was found to be 24.