[Pharmacokinetic differences and related mechanisms of ginkgo flavone aglycone in normal and atherosclerotic rats in vivo].

This study aimed to compare the pharmacokinetics of ginkgo flavone aglycone(GA) in plasma after oral administration of GA in normal and atherosclerosis(AS) model rats and to explore the mechanism of pharmacokinetic differences. The AS rats were prepared by using high-fat diets. Rats in the normal and AS model groups were orally given 200 mg·kg~(-1) GA, blood samples were collected at different time points, plasma was separated, and the plasma concentrations of quercetin, kaempferol and isorhamnetin in the normal and AS model groups were determined by ultra-performance liquid chromatography-mass spectrometry(UPLC-MS/MS).

[Cell metabolomics study of ginkgo flavone aglycone combined with doxorubicin against liver cancer in synergy].

Ultra-high-performance liquid chromatography-Q exactive orbitrap tandem mass spectrometry(UHPLC-QEOrbitrap-MS/MS) was used to explore the inhibitory effect and mechanism of ginkgo flavone aglycone(GA) combined with doxorubicin(DOX) on H22 cells. The effects of different concentrations of GA and DOX on the viability of H22 cells were investigated, and combination index(CI) was used to evaluate the effects. In the experiments, control(CON) group, DOX group, GA group, and combined GA and DOX(GDOX) group were constructed.

Desulfonylative Electrocarboxylation with Carbon Dioxide.

Electrocarboxylation of organic halides is one of the most investigated electrochemical approaches for converting thermodynamically inert carbon dioxide (CO) into value-added carboxylic acids. By converting organic halides into their sulfone derivatives, we have developed a highly efficient electrochemical desulfonylative carboxylation protocol. Such a strategy takes advantage of CO as the abundant C1 building block for the facile preparation of multifunctionalized carboxylic acids, including the nonsteroidal anti-inflammatory drug ibuprofen, under mild reaction conditions.