Dietary methionine supplementation promotes mice hematopoiesis after irradiation.

Background: With the increasing risk of nuclear exposure, more attention has been paid to the prevention and treatment of acute radiation syndrome (ARS). Although amino acids are key nutrients involved in hematopoietic regulation, the impacts of amino acids on bone marrow hematopoiesis following irradiation and the associated mechanisms have not been fully elucidated. Hence, it is of paramount importance to study the changes in amino acid metabolism after irradiation and their effects on hematopoiesis as well as the related mechanisms.

Two-dimensional multifunctional metal-organic frameworks with large in-plane negative Poisson ratios and photocatalytic water splitting properties.

Auxetic materials with multifunctional properties are highly sought after for application in modern nano-devices. However, the majority of reported inorganic auxetic materials exhibit low negative Poisson's ratios (NPR), poor flexibility, and limited functionality. In this study, we employ density-functional-theory (DFT) first-principles simulations to design a series of two-dimensional (2D) metal-organic frameworks (MOFs) MCX (M = Cu, Ag, Au; X = O, S, NCN) that display intriguing auxetic behavior, superior flexibility and appropriate photocatalytic water-splitting properties.

Enantioselective Synthesis of Oxazocines via MQ-Phos Enabled Palladium-Catalyzed Asymmetric Formal [4+4]-Cycloadditions.

Oxazocines are key structural intermediates in the synthesis of natural products and pharmaceutical molecules. However, the synthesis of oxazocines especially in a highly enantioselective manner, is a long-standing formidable challenge due to unfavorable energetics involved in cyclization. Herein, a series of new PNP-Ligand P-chiral stereocenter is first designed and synthesized, called MQ-Phos, and successfully applied it in the Pd-catalyzed enantioselective higher-order formal [4+4]-cycloaddition of α, β-unsaturated imines with 2-(hydroxymethyl)-1-arylallyl carbonates.

GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines.

Background: Thrombocytopenia 2, an autosomal dominant inherited disease characterized by moderate thrombocytopenia, predisposition to myeloid malignancies and normal platelet size and function, can be caused by 5'-untranslated region (UTR) point mutations in ankyrin repeat domain containing 26 (ANKRD26). Runt related transcription factor 1 (RUNX1) and friend leukemia integration 1 (FLI1) have been identified as negative regulators of . However, the positive regulators of are still unknown.

GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break repair and determining cancer radiosensitivity.

Background: DNA double-strand break (DSB) induction and repair are important events for determining cell survival and the outcome of cancer radiotherapy. The DNA-dependent protein kinase (DNA-PK) complex functions at the apex of DSBs repair, and its assembly and activity are strictly regulated by post-translation modifications (PTMs)-associated interactions. However, the PTMs of the catalytic subunit DNA-PKcs and how they affect DNA-PKcs's functions are not fully understood.

Large tunneling magnetoresistance in spin-filtering 1T-MnSe/h-BN van der Waals magnetic tunnel junction.

The magnetic tunnel junction (MTJ), one of the most prominent spintronic devices, has been widely utilized for memory and computation systems. Electrical writing is considered as a practical method to enhance the performance of MTJs with high circuit integration density and ultralow-power consumption. Meanwhile, a large tunneling magnetoresistance (TMR), especially at the non-equilibrium state, is desirable for the improvement of the sensitivity and stability of MTJ devices.

Genome-wide identification and skin expression of immunoglobulin superfamily in discus fish (Symphysodon aequifasciatus) reveal common genes associated with vertebrate lactation.

Discus Symphysodon spp. employs an unusual parental care behavior where fry feed on parental skin mucus after hatching. Studies on discus immunoglobulin superfamily (IgSF) especially during parental care are scarce.

Microplastics drive nitrification by enriching functional microorganisms in aquaculture pond waters.

The plastisphere refers to biofilm formation on the microplastic (MP) surface, but its subsequent functions, especially driving the nitrogen biogeochemical cycle, are rarely studied. Here, MPs were incubated in the pelagic water and benthic water-sediment interface of an aquaculture pond, and the two corresponding microcosms amended with incubated plastisphere were simulated. The results showed decreased ammonia concentrations and increased nitrification rates in microcosms with either pelagic or benthic plastispheres.

Neutrophil-to-Lymphocyte Ratio Is Associated With Circumferential Wall Enhancement of Unruptured Intracranial Aneurysm.

Background And Purpose: Neutrophil-lymphocyte ratio (NLR) predicts clinical outcomes in patients with stroke. Aneurysm wall enhancement (AWE) on high-resolution vessel wall magnetic resonance imaging (HR-VWI) is an inflammation marker for intracranial aneurysm (IA). This study aims to evaluate the association of NLR as a peripheral blood inflammatory marker with circumferential AWE in patients with IA.

Circumferential wall enhancement with contrast ratio measurement in unruptured intracranial aneurysm for aneurysm instability.

Background: Aneurysm wall enhancement on high-resolution vessel wall imaging (HR-VWI) may represent vessel wall inflammation for unruptured intracranial aneurysms (UIAs). Further evidence for the role of circumferential aneurysm wall enhancement (CAWE) in evaluating the instability of UIAs is required, especially in small aneurysms (<7 mm).

Methods: We analyzed patients with saccular UIAs who prospectively underwent HR-VWI on a 3.

Au Nanoclusters Incorporating Three-Dimensionally Ordered Macroporous InO for Highly Sensitive and Selective Formaldehyde Sensing.

Detection of formaldehyde () in the atmosphere is of significant importance because exposure to may cause serious health problems such as sick-house syndrome, leukemia, and cancer. Modifying metal oxide semiconductors (MOSs) with noble metal nanoparticles (NPs) is an efficient method to enhance -sensing properties. Herein, a series of Au nanocluster (NC)-decorated three-dimensionally ordered macroporous InO materials (Au/3DOM InO) is created, and the loading amount of Au NCs was optimized based on responses.

Embryonic Origin and Subclonal Evolution of Tumor-Associated Macrophages Imply Preventive Care for Cancer.

Macrophages are widely distributed in tissues and function in homeostasis. During cancer development, tumor-associated macrophages (TAMs) dominatingly support disease progression and resistance to therapy by promoting tumor proliferation, angiogenesis, metastasis, and immunosuppression, thereby making TAMs a target for tumor immunotherapy. Here, we started with evidence that TAMs are highly plastic and heterogeneous in phenotype and function in response to microenvironmental cues.

Substantial and stable magnetoresistance and spin conductance in phosphorene-based spintronic devices with Co electrodes.

Designing devices with excellent spin-polarized properties has been a challenge in physics and materials science. In this work, we report a theoretical investigation of the spin injection and spin-polarized transport properties of monolayer and bilayer phosphorene devices with Co electrodes. Based on the analysis of transmission coefficients, spin-polarized current, magnetoresistance (MR) (or tunnel MR) ratio and spin injection efficiency (SIE), both devices show superior spin-polarized transport properties.

Selective Photocatalytic Reduction of CO to CH Modulated by Chloride Modification on BiWO Nanosheets.

Solar-driven photocatalytic CO reduction into CH with HO is considered to be a promising way to alleviate the energy crisis and greenhouse effect. However, current CO photoreduction technologies tend to overlook the role of photooxidation half reaction as well as the effect of the protons produced by water oxidation on CH generation, resulting in low CO conversion efficiency and poor CH selectivity. In the present study, a series of chloride-modified BiWO nanosheets were constructed in view of chloride-assisted photocatalytic water oxidation.

Direct Tellurization of Pt to Synthesize 2D PtTe for High-Performance Broadband Photodetectors and NIR Image Sensors.

Platinum telluride (PtTe) has garnered significant research enthusiasm owing to its unique characteristics. However, large-scale synthesis of PtTe toward potential photoelectric and photovoltaic application has not been explored yet. Herein, we report direct tellurization of Pt nanofilms to synthesize large-area PtTe films and the influence of growth conditions on the morphology of PtTe.

First-principles study of two dimensional CN and its derivatives.

Here we have performed a comprehensive first-principles study for electronic and mechanical properties of newly synthesized CN and its derivatives. The CN monolayer is evaluated to be an indirect semiconductor with a HSE06 level bandgap of 1.09 eV, which can be effectively tuned by the number of layers, stacking order and B-doping concentration.

N-Doped Graphene Quantum Dot-Decorated Three-Dimensional Ordered Macroporous InO for NO Sensing at Low Temperatures.

Nitrogen dioxide (NO) detection is of great importance because the emission of NO gas profoundly endangers the natural environment and human health. However, a few challenges, including lowering detection limit, improving response/recovery kinetics, and reducing working temperature, should be further addressed before practical applications. Herein, a series of N-doped graphene quantum dot (N-GQD)-modified three-dimensional ordered macroporous (3DOM) InO composites are constructed and their NO response properties are studied.

CR6-interacting factor-1 contributes to osteoclastogenesis by inducing receptor activator of nuclear factor κB ligand after radiation.

Background: Radiation induces rapid bone loss and enhances bone resorption and adipogenesis, leading to an increased risk of bone fracture. There is still a lack of effective preventive or therapeutic method for irradiation-induced bone injury. Receptor activator of nuclear factor κB ligand (RANKL) provides the crucial signal to induce osteoclast differentiation and plays an important role in bone resorption.

Primary mediastinal ependymoma: A case report and literature review.

Rationale: Ependymomas are neuroepithelial tumors that typically occur in the central nervous system. Ependymomas arising in the mediastinum are exceedingly rare, with only approximately 9 isolated cases reported in the literature to date.

Patient Concerns: A 35-year-old woman was referred to our hospital with complaints of progressive back pain for 3 months.

Bioactivity and safety of chimeric switch receptor T cells in glioblastoma patients.

Experimental evidence has shown that chimeric switch receptor T (CSR-T) cells, activated by binding programmed death-ligand 1 on the tumor cell surface, lead to tumor regression in experimental animals. In this phase I clinical study, we evaluated the safety and bioactivity of CSR-T cell therapy in 14 patients with recurrent glioblastoma who were unresponsive to surgical resection and standard radiotherapy. Patients who received 10 CSR-T cells either intravenously or intracranially showed an increase in the levels of IFN-gamma and IL-6, respectively, in peripheral blood or cerbrospinal fluid (CSF).

Correction: Ionic-liquid supported rapid synthesis of an N-glycan core pentasaccharide on a 10 g scale.

Correction for 'Ionic-liquid supported rapid synthesis of an N-glycan core pentasaccharide on a 10 g scale' by Wei Li et al., Org. Biomol.

Natural sunlight driven highly efficient photocatalysis for simultaneous degradation of rhodamine B and methyl orange using I/C codoped TiO photocatalyst.

Increasing the efficiency of dye degradation is a critical issue for the application for photocatalysis. It is one of the greatest challenges to enhance the utilization of photo generated carriers in semiconductor, especially for sunlight irradiation. In this study, I/C-codoped TiO was synthesized by a simple solvothermal-calcination method.

Ionic-liquid supported rapid synthesis of an N-glycan core pentasaccharide on a 10 g scale.

A new and efficient Ionic Liquid-Supported Oligosaccharide Synthesis (ILSOS) strategy for an N-linked core pentasaccharide on a 10 g scale is reported. This new ILSOS includes a new spacer for an IL support, a new tagging strategy, and fast, efficient and orthogonal removal of the ionic-liquid support, producing the N-linked core pentasaccharide with direct applicability potential in a short time, with high yield and on a large gram scale.

The Surgical Treatment of Posttraumatic Skull Base Defects with Cerebrospinal Fluid Leak.

 The objective was to explore further the surgical treatment of posttraumatic skull base defects with cerebrospinal fluid (CSF) leak and to identify the most common factors affecting the surgical treatment of posttraumatic skull base defect with CSF leak retrospectively.  This study included 144 patients with head trauma having skull base defect with CSF leak who had been surgically treated at Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University from 1998 to June 2016. There were 113 (78.