Publications by authors named "Zhong-Jun Jiang"
Pirfenidone promotes cell cycle arrest and apoptosis of triple‑negative breast cancer cells by suppressing Hedgehog/GLI1 signaling.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Article Synopsis
- Breast cancer, especially triple-negative breast cancer (TNBC), presents a significant challenge due to its aggressive nature and poor prognosis, prompting research into potential treatments like pirfenidone, an FDA-approved drug with anti-fibrotic and emerging anti-tumor properties.
- In experiments, pirfenidone was shown to reduce cell viability and proliferation in TNBC cell lines (MDA-MB-231 and HCC-1937), shifting more cells into the G0/G1 phase of the cell cycle and inducing apoptosis by altering specific protein expressions related to cell survival and apoptosis.
- The study revealed that pirfenidone's effectiveness is linked to its suppression of the Hedgehog/GLI1 signaling pathway, as
[Clinical and imaging features of 36 odontogenic keratocysts associated with an impacted tooth].
Shanghai Kou Qiang Yi Xue
February 2019
Purpose: To analyse the imaging features of odontogenic keratocysts (OKCs) associated with an impacted tooth.
Methods: Clinical and radiological data of 235 cases with OKCs were respectively investigated, with emphasis on imaging features of 36 OKCs, which were associated with an unerupted tooth.
Results: In 36 cases of OKCs associated with an impacted tooth, the ratio of male to female was 1.
Background/aims: Peptide hormone somatostatin and its receptors (SSTRs) have a wide range of physiological functions and play a role in the treatment of numerous human diseases, including colorectal cancer. Octreotide, a somatostatin-analog peptide, inhibits growth of colonic cancer SW480 cells through Wnt/β-catenin pathway modulation. However, the specific octreotide-stimulating SSTR subtypes and the signal-transduction mechanism responsible for the negative regulation of Wnt/β-catenin pathway by octreotide have not been fully elucidated.
View Article and Find Full Text PDF