Upregulation of Promotes Cell Proliferation, Migration, and Predicts Poor Prognosis in Ovarian Cancer Through Regulating Epithelial-Mesenchymal Transformation.

There is little knowledge about the biological roles and clinical significance of in ovarian cancer. Thus, the objective of this study was to investigate the biological functions and prognosis value of in ovarian cancer to further seek a potential therapeutic target for patients with ovarian cancer. First, the expression level of in ovarian cancer samples obtained from ONCOMINE database was determined, and its expression in cell lines was also investigated.

Screening and identification of significant genes related to tumor metastasis and PSMA in prostate cancer using microarray analysis.

Tumor metastasis is one of the causes for the high mortality rate of prostate cancer (PCa) patients, yet the molecular mechanisms of PCa metastasis are not fully understood. In our previous studies, we found that PSMA suppresses the metastasis of PCa, yet the underlying mechanism remains unknown. To identify the genes related to tumor metastasis possibly regulated by PSMA, we performed tumor metastasis PCR array assay to analyze the differentially expressed tumor metastasis-related genes.