3D-Porous Carbon Nitride Through Proton Regulation and Photocatalytic Synergy for Efficient Uranium Extraction From Seawater.

Extracting uranium from seawater is crucial for tapping oceanic resources vital to future energy supply. This study synthesized a novel nitrogen vacancy carbon nitride (NCN) grafted polyethyleneimine (PEI) composite material (NCNP). Experiments and molecular dynamics simulations reveal that NCNP effectively hinders the diffusion of uranyl ions (UO ) to the NCN surface, thereby inhibiting electron transfer reactions.

SNX4 Is Correlated With Immune Infiltration and Prognosis in Clear Cell Renal Cell Carcinoma.

Background: Clear cell renal cell carcinoma (ccRCC) is known as the most common and malignant histologic subtype of renal carcinoma. Sorting nexin 4 (SNX4) plays a regulatory role in recycling from endosomes to the plasma membrane and promotes autophagosome assembly and transport, which may exert the cancerous growth and progression. This study aimed to assess the biological role of SNX4 in ccRCC and their clinical association via public biological data platforms combined with experimental verification.

Patient-specific finite element analysis of four different fixation methods for transversely unstable radial head fractures.

Plate fixation is a common treatment option for radial head fractures (RHFs). Due to the benefits of less invasiveness and fewer complications of internal fixation, the application of small-diameter headless compression screws (HCSs) to treat RHFs has become a new trend. This study aimed to compare the mechanical stability of four distinct internal fixation protocols for transversely unstable RHFs via finite element analysis.

Nitrogen-doped titanium dioxide/schwertmannite nanocomposites as heterogeneous photo-Fenton catalysts with enhanced efficiency for the degradation of bisphenol A.

Potential health risks related to environmental endocrine disruptors (EEDs) have aroused research hotspots at the forefront of water treatment technologies. Herein, nitrogen-doped titanium dioxide/schwertmannite nanocomposites (N-TiO/SCH) have been successfully developed as heterogeneous catalysts for the degradation of typical EEDs via photo-Fenton processes. Due to the sustainable Fe(III)/Fe(II) conversion induced by photoelectrons, as-prepared N-TiO/SCH nanocomposites exhibit much enhanced efficiency for the degradation of bisphenol A (BPA; ca.

Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects.

One of the major hurdles that has hindered the success of chimeric antigen receptor (CAR) T cell therapies against solid tumors is on-target off-tumor (OTOT) toxicity due to sharing of the same epitopes on normal tissues. To elevate the safety profile of CAR-T cells, an affinity/avidity fine-tuned CAR was designed enabling CAR-T cell activation only in the presence of a highly expressed tumor associated antigen (TAA) but not when recognizing the same antigen at a physiological level on healthy cells. Using direct stochastic optical reconstruction microscopy (dSTORM) which provides single-molecule resolution, and flow cytometry, we identified high carbonic anhydrase IX (CAIX) density on clear cell renal cell carcinoma (ccRCC) patient samples and low-density expression on healthy bile duct tissues.

Electroantennographic and Behavioral Responses of the Melon fly, Zeugodacus cucurbitae (Coquillett), to Volatile Compounds of Ridge Gourd, Luffa acutangular L.

The melon fly, Zeugodacus cucurbitae (Coquillett), is a major invasive pest, widely distributed in the Asia-Pacific region and some parts of Africa. Melon fly attractants could improve the effectiveness of current pest management measures. Previous studies have shown that some host fruits are attractive to melon flies but few have investigated the chemical compounds responsible for their attraction.

Towards Generalized Few-Shot Open-Set Object Detection.

Open-set object detection (OSOD) aims to detect the known categories and reject unknown objects in a dynamic world, which has achieved significant attention. However, previous approaches only consider this problem in data-abundant conditions, while neglecting the few-shot scenes. In this paper, we seek a solution for the generalized few-shot open-set object detection (G-FOOD), which aims to avoid detecting unknown classes as known classes with a high confidence score while maintaining the performance of few-shot detection.

Effectiveness and safety of Moluodan in the treatment of precancerous lesions of gastric cancer: A randomized clinical trial.

Objective: To investigate the clinical potential and safety of Moluodan to reverse gastric precancerous lesions.

Methods: Patients aged 18-70 years diagnosed with moderate-to-severe atrophy and/or moderate-to-severe intestinal metaplasia, with or without low-grade dysplasia, and negative for Helicobacter pylori were recruited in this randomized, double-blind, parallel-controlled trial. The primary outcome was the improvement of global histological diagnosis at 1-year follow-up endoscopy using the operative link for gastritis assessment, the operative link for gastric intestinal metaplasia assessment, and the disappearance rate of dysplasia.

Supraspinatus extraction from MRI based on attention-dense spatial pyramid UNet network.

Background: With potential of deep learning in musculoskeletal image interpretation being explored, this paper focuses on the common site of rotator cuff tears, the supraspinatus. It aims to propose and validate a deep learning model to automatically extract the supraspinatus, verifying its superiority through comparison with several classical image segmentation models.

Method: Imaging data were retrospectively collected from 60 patients who underwent inpatient treatment for rotator cuff tears at a hospital between March 2021 and May 2023.

infection in Xinjiang Uyghur Autonomous Region: Prevalence and analysis of related factors.

Background: C urea breath test (C UBT) and immunohistochemical staining (IHC) are widely used for detection () infection with different sensitivity, and there is a difference in infection rate in Uyghur and Han ethnic groups. Both need large cohort studies to evaluate the differences more accurately.

Aim: To analyze the difference between C UBT and IHC for detection in Xinjiang Uyghur Autonomous Region and the difference between Uyghur and Han populations.

Context and Spatial Feature Calibration for Real-Time Semantic Segmentation.

Context modeling or multi-level feature fusion methods have been proved to be effective in improving semantic segmentation performance. However, they are not specialized to deal with the problems of pixel-context mismatch and spatial feature misalignment, and the high computational complexity hinders their widespread application in real-time scenarios. In this work, we propose a lightweight Context and Spatial Feature Calibration Network (CSFCN) to address the above issues with pooling-based and sampling-based attention mechanisms.

Clinical evaluation of ventilation mode on acute exacerbation of chronic obstructive pulmonary disease with respiratory failure.

Background: At present, understanding of the most effective ventilation methods for treating chronic obstructive pulmonary disease (COPD) patients experiencing acute worsening symptoms and respiratory failure remains relatively limited. This report analyzed the efficiency and side effects of various ventilation techniques used for individuals experiencing an acute COPD exacerbation.

Aim: To determine whether pressure-controlled ventilation (PCV) can lower peak airway pressures (PAPs) and reduce the incidence of barotrauma compared to volume-controlled ventilation (VCV), without compromising clinical outcomes and oxygenation parameters.

Constitutive Damage Model of Foamed Lightweight Concrete Using Statistical Damage Theory.

Foamed lightweight concrete has been applied in different fields of civil engineering because of its superior properties, but the related research considering internal pore damage is limited. Based on statistical damage theory and considering the uneven distribution of fracture damage and strength between the pores of light concrete, a damage constitutive model of foamed lightweight concrete was established based on the Weibull function. The parameters of the damage model were determined through a triaxial compression test, and the rationality was verified by combining the existing test data.

Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma.

Apoptosis alteration is responsible for tumorigenesis and tumor resistance to therapies. The natural product Tanshinone IIA (Tan IIA) exhibits potent inhibitory effects against various tumors. However, the effect of Tan IIA on apoptosis and its underlying mechanism remains elusive in oral squamous cell carcinoma (OSCC).

Mechanism insights into photo-assisted peroxymonosulfate activation on oxygen vacancy-enriched nolanites via an electron transfer regime.

The utilization of photo-assisted persulfate activation for the removal of organic contaminants in water has garnered significant research interest in recent times. However, there remains a lack of clarity regarding specific contributions of light irradiation and catalyst structure in this process. Herein, a photo-assisted peroxymonosulfate (PMS) activation system is designed for the highly efficient degradation of organic contaminants on oxygen vacancy-enriched nolanites (Vo-FVO).

Relationships Between Inflammatory Parameters Derived From Complete Blood Count and Quantitative Flow Ratio in Patients With Stable Coronary Artery Disease.

To investigate the relationships between inflammatory parameters, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII), and quantitative flow ratio (QFR) in stable coronary artery disease (CAD) patients ( = 450) enrolled in this cross-sectional study. Logistic regression was performed to evaluate the associations of NLR, PLR, MLR, and SII evaluated as continuous and binary variables with QFR ≤0.80.

Automatic Medical Report Generation Based on Cross-View Attention and Visual-Semantic Long Short Term Memorys.

Automatic medical report generation based on deep learning can improve the efficiency of diagnosis and reduce costs. Although several automatic report generation algorithms have been proposed, there are still two main challenges in generating more detailed and accurate diagnostic reports: using multi-view images reasonably and integrating visual and semantic features of key lesions effectively. To overcome these challenges, we propose a novel automatic report generation approach.

Prediction of fractional flow reserve with enhanced ant lion optimized support vector machine.

The evaluation of coronary morphology provides important guidance for the treatment of coronary heart disease (CHD). A chaotic Gaussian mutation antlion optimizer algorithm (CGALO) is proposed in the paper, and it is combined with SVM to construct a classification prediction model for Fractional flow reserve (FFR). To overcome the limitations of the original antlion optimizer (ALO) algorithm, the chaotic Gaussian mutation strategy is introduced, which leads to an improvement in its convergence speed and accuracy.

Femoral neck system and cannulated compression screws in the treatment of non-anatomical reduction Pauwels type-III femoral neck fractures: A finite element analysis.

Background: High shear force is a major factor detrimental to the healing of vertical femoral neck fractures. In addition to firm fixation, reduction quality is crucial for postoperative stability. The present study aimed to compare the biomechanical stability of the newly invented femoral neck system and three inverted-triangle cannulated compression screws treatments for non-anatomical reduction of Pauwels type-III femoral neck fractures.

Synergistic enhanced activation of peroxymonosulfate by heterojunction CoO-CuO@CN for removal of oxytetracycline: Performance, mechanism, and stability.

Metal-organic frameworks (MOFs) as precursors for catalysts has drawn growing attentions. In this study, heterojunction CoO-CuO doped carbon materials (noted as CoO-CuO@CN) were prepared by direct carbonization of CuCo-MOF in air. It was found that the CoO-CuO@CN-2 exhibited excellent catalytic activity with the highest Oxytetracycline (OTC) degradation rate of 0.

Progranulin inhibits fibrosis by interacting with and up-regulating DNAJC3 during mouse skin wound healing.

Scars place a heavy burden on both individuals and society. Our previous study found that reduction of progranulin (PGRN) promotes fibrogenesis in mouse skin wound healing. However, the underlying mechanisms have not been elucidated.

Predictive Value of Noninvasive Peripheral Atherosclerosis Measurement for Coronary Artery Disease in Patients with Long T2DM Duration.

Objective: This study aimed to compare the predictive value of carotid or femoral artery ultrasound for coronary artery disease (CAD) in type 2 Diabetes mellitus (T2DM) patients free from known CAD, and to assess the relationship with the severity of coronary artery stenosis.

Methods: Cross-sectional study in adults with a T2DM duration of at least 5 years and without established CAD. Carotid plaque score (CPS) and Gensini score were used to measure the severity of carotid and coronary artery stenosis, respectively, and patients were divided into no or mild group, moderate group, and severe group according to the tertile of the score.

Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE).

Single-molecule characterization of protein-DNA dynamics provides unprecedented mechanistic details about numerous nuclear processes. Here, we describe a new method that rapidly generates single-molecule information with fluorescently tagged proteins isolated from nuclear extracts of human cells. We demonstrated the wide applicability of this novel technique on undamaged DNA and three forms of DNA damage using seven native DNA repair proteins and two structural variants, including: poly(ADP-ribose) polymerase (PARP1), heterodimeric ultraviolet-damaged DNA-binding protein (UV-DDB), and 8-oxoguanine glycosylase 1 (OGG1).