The mechanism of quercetin in treating intracerebral hemorrhage was investigated by network pharmacology and molecular docking.

Background: The aim of this study was to explore the molecular mechanism of quercetin in the treatment of intracerebral hemorrhage.

Methods: Quercetin target genes and intracerebral hemorrhage target genes were collected from 5 databases. After standardized conversion of the obtained target genes through uniprot database, cross genes of the 2 were obtained using Venny 2.

Additive-controlled asymmetric iodocyclization enables enantioselective access to both α- and β-nucleosides.

β-Nucleosides and their analogs are dominant clinically-used antiviral and antitumor drugs. α-Nucleosides, the anomers of β-nucleosides, exist in nature and have significant potential as drugs or drug carriers. Currently, the most widely used methods for synthesizing β- and α-nucleosides are via N-glycosylation and pentose aminooxazoline, respectively.

Modeling and Estimation of CO Emissions in China Based on Artificial Intelligence.

Since China's reform and opening up, the social economy has achieved rapid development, followed by a sharp increase in carbon dioxide (CO) emissions. Therefore, at the 75th United Nations General Assembly, China proposed to achieve carbon peaking by 2030 and carbon neutrality by 2060. The research work on advance forecasting of CO emissions is essential to achieve the above-mentioned carbon peaking and carbon neutrality goals in China.

Arabidopsis SKU5 Similar 11 and 12 play crucial roles in pollen tube integrity, growth and guidance.

Pollen tube integrity, growth and guidance are crucial factors in plant sexual reproduction. Members of the plant Skewed5 (SKU5) Similar (SKS) family show strong similarity to multicopper oxidases (MCOs), but they lack conserved histidines in MCO active sites. The functions of most SKS family members are unknown.