Biomass-derived carbon dots (BCDs) have attracted considerable attention for their promising attributes, including low toxicity, excellent solubility, biocompatibility, and eco-friendliness. Their rich surface chemistry and impressive photoluminescent properties have sparked widespread research interest, particularly in areas such as sensing and biomedicine. However, the potential applications of BCDs in the energy sector, especially in electrochemical energy storage batteries, have received scant review focus.
View Article and Find Full Text PDFRationale And Objectives: This study constructed an interpretable machine learning model based on multi-parameter MRI sub-region habitat radiomics and clinicopathological features, aiming to preoperatively evaluate the microsatellite instability (MSI) status of rectal cancer (RC) patients.
Materials And Methods: This retrospective study recruited 291 rectal cancer patients with pathologically confirmed MSI status and randomly divided them into a training cohort and a testing cohort at a ratio of 8:2. First, the K-means method was used for cluster analysis of tumor voxels, and sub-region radiomics features and classical radiomics features were respectively extracted from multi-parameter MRI sequences.
Background: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is considered one of the most severe complications of rheumatoid arthritis. The etiology of RA-ILD is complex, involving genetic and environmental factors. Recent studies suggest that the gut microbiota, a critical component of the immune system, may influence the pathogenesis of RA and other autoimmune disorders.
View Article and Find Full Text PDFBackground: Limited evidence exists about the relationship between serum carotenoid and mortality in metabolic syndrome (MetS) patients, and the effects of medication use on this association remains unclear.
Methods: The study encompassed 2,521 MetS patients from the National Health and Nutrition Examination Survey (NHANES) 2001-2006 and 2017-2018. A total of 7 serum carotenoids were evaluated.
With the development of deep learning technology and the widespread application of drones in the agricultural sector, the use of computer vision technology for target detection of pineapples has gradually been recognized as one of the key methods for estimating pineapple yield. When images of pineapple fields are captured by drones, the fruits are often obscured by the pineapple leaf crowns due to their appearance and planting characteristics. Additionally, the background in pineapple fields is relatively complex, and current mainstream target detection algorithms are known to perform poorly in detecting small targets under occlusion conditions in such complex backgrounds.
View Article and Find Full Text PDFAutoimmune diseases often exhibit a preclinical stage before diagnosis. Electronic health record (EHR) based-biobanks contain genetic data and diagnostic information, which can identify preclinical individuals at risk for progression. Biobanks typically have small numbers of cases, which are not sufficient to construct accurate polygenic risk scores (PRS).
View Article and Find Full Text PDFWhile investigating macrofungi diversity in Gansu province, northwestern China, five fresh and fleshy specimens were collected, which are characterized by nearly white to buff hemispherical pileus with waved margins, a disc depressed with coral to brownish red fibrillose scales, adnate to sub-decurrent lamellae with four relatively regular rows of lamellulae, a stipe that is central, hollow, frequently straight to curved; basidiospores that are globose to subglobose, 5.0-6.0 × (3.
View Article and Find Full Text PDFAvatrombopag is a next-generation thrombopoietin receptor agonist approved for the treatment of thrombocytopenia in patients with chronic liver disease scheduled to undergo surgery and thrombocytopenia in patients with chronic immune thrombocytopenia. However, realistic data on its post-marketing long-term safety and tolerability in large sample populations are incomplete. The adverse event (AE) reports of avatrombopag were analyzed based on the FAERS database.
View Article and Find Full Text PDFIEEE Trans Med Imaging
November 2024
Aneurysm segmentation in computed tomography angiography (CTA) images is essential for medical intervention aimed at preventing subarachnoid hemorrhages. However, most existing studies tend to overlook the topological characteristics of arteries related to aneurysms, often resulting in suboptimal performance in aneurysm segmentation. To address this challenge, we propose an arteryaware global-to-local framework for aneurysm segmentation (AASeg) using CTA images of head and neck.
View Article and Find Full Text PDFRoom-temperature sodium-sulfur (RT Na-S) batteries with high energy density and low cost are considered promising next-generation electrochemical energy storage systems. However, their practical feasibility is seriously impeded by the shuttle effect of sodium polysulfide (NaPSs) resulting from the sluggish reaction kinetics. Introducing a suitable catalyst to accelerate conversion of NaPSs is the most used strategy to inhibit the shuttle effect.
View Article and Find Full Text PDFJ Colloid Interface Sci
February 2025
Front Microbiol
September 2024
Introduction: Cortinariaceae, which belongs to the Agaricales order, is a globally recognized family, known for its high species diversity.
Methods: Eight internal transcribed spacer (ITS) and nuclear large ribosomal subunit (LSU) sequences were newly generated, and phylogenetic analyses were performed by combining ITS and LSU datasets. Four species were identified as forming four independent lineages with robust support in phylogenies based on both datasets.
The use of matrix completion methods to predict the association between microbes and diseases can effectively improve treatment efficiency. However, the similarity measures used in the existing methods are often influenced by various factors such as neighbourhood size, choice of similarity metric, or multiple parameters for similarity fusion, making it challenging. Additionally, matrix completion is currently limited by the sparsity of the initial association matrix, which restricts its predictive performance.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
July 2024
Despite the availability of life-extending treatments for B cell leukemias and lymphomas, many of these cancers remain incurable. Thus, the development of new molecular targets and therapeutics is needed to expand treatment options. To identify new molecular targets, we used a forward genetic screen in mice to identify genes required for development or survival of lymphocytes.
View Article and Find Full Text PDFBackground: Functioning adrenal adenoma during pregnancy is rare, and the diagnosis is challenging owing to unspecific symptoms and restricted investigations. The obstetric outcomes of patients who undergo surgery during pregnancy or who receive only medical treatment are poorly described.
Objective: The aim was to investigate the associations between functioning adrenal adenomas and obstetric outcomes.
Angew Chem Int Ed Engl
October 2024
The practical application of solid polymer electrolyte is hindered by the small transference number of Li, low ionic conductivity and poor interfacial stability, which are seriously determined by the microenvironment in polymer electrolyte. The introduction of functional fillers is an effective solution to these problems. In this work, based on density functional theory (DFT) calculations, it is demonstrated that the anion vacancy of filler can anchor anions of lithium salt, thereby significantly increasing the transference number of Li in the electrolyte.
View Article and Find Full Text PDFMedical image analysis poses significant challenges due to limited availability of clinical data, which is crucial for training accurate models. This limitation is further compounded by the specialized and labor-intensive nature of the data annotation process. For example, despite the popularity of computed tomography angiography (CTA) in diagnosing atherosclerosis with an abundance of annotated datasets, magnetic resonance (MR) images stand out with better visualization for soft plaque and vessel wall characterization.
View Article and Find Full Text PDFThe structural failure of NaMn[Fe(CN)] could not be alleviated with traditional modification strategies through the adjustable composition property of Prussian blue analogues (PBAs), considering that the accumulation and release of stress derived from the MnN octahedrons are unilaterally restrained. Herein, a novel application of adjustable composition property, through constructing a coordination competition relationship between chelators and [Fe(CN)] to directionally tune the enrichment of elements, is proposed to restrain structural degradation and induce unconventional energy coupling phenomenon. The non-uniform distribution of elements at the M site of PBAs (NFM-PB) is manipulated by the sequentially precipitated Ni, Fe, and Mn according to the Irving-William order.
View Article and Find Full Text PDFSignals emanating from the T-cell receptor (TCR), co-stimulatory receptors, and cytokine receptors each influence CD8 T-cell fate. Understanding how these signals respond to homeostatic and microenvironmental cues can reveal new ways to therapeutically direct T-cell function. Through forward genetic screening in mice, we discover that loss-of-function mutations in LDL receptor-related protein 10 (Lrp10) cause naive and central memory CD8 T cells to accumulate in peripheral lymphoid organs.
View Article and Find Full Text PDFReal-time detection of harmful gases at room temperature has become a serious problem in public health and environmental monitoring. Two-dimensional materials with semiconductor properties BiOCl is a promising gas-sensitive material due to its large specific surface area and adjustable band gap as well as outstanding safety characteristics. However, limited by the weak gas adsorption sites and sluggish charge-transfer ability, the performance of BiOCl could not be fully exploited.
View Article and Find Full Text PDFMulti-phase dynamic contrast-enhanced magnetic resonance imaging image registration makes a substantial contribution to medical image analysis. However, existing methods (e.g.
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