RLA8-A New and Highly Effective Quadruple PPAR-// and GPR40 Agonist to Reverse Nonalcoholic Steatohepatitis and Fibrosis.

Nonalcoholic fatty liver disease (NAFLD) is a very common chronic hepatic disease, with nonalcoholic steatohepatitis (NASH) as a major and severe subcategory that can lead to cirrhosis and hepatocellular carcinoma, and thereby to a high mortality rate. Currently, there has been no approved drug to treat NAFLD or NASH. The current study has presented RLA8, a novel and balanced quadruple agonist for hepatic lipid metabolism and inflammation-related peroxisome proliferator-activated receptors (PPARs)-// and G protein-coupled receptor 40 (GPR40), as a NASH drug candidate.

Enhanced interferon-gamma secretion and antitumor activity of T-lymphocytes activated by dendritic cells loaded with glycoengineered myeloma antigens.

Background: Immunotherapy is emerging as a promising cure for cancer. However, a severe problem in this area is the immune tolerance to tumor cells and tumor-associated antigens, as evidenced by the ability of cancer to escape immune surveillance. To overcome this problem this work examined the potential of improving the antigenicity of myeloma by metabolic engineering of its cell surface carbohydrate antigens (i.

[Measurement and statistical analysis of the vertical force in normal young people's gait].

Objective: To find a method for evaluating the relationship between mechanical data and gait efficiently.

Method: Gait mechanical data of 27 young men (20-22 years) without history of the kinetic diseases were collected using a force-measuring system. The data were transformed into characteristic two-peak curves in vertical direction (z-axis).

[A gait analysis system based on digital video and digital image processing].

Objective: To provide a gait analysis system.

Method: The system is composed of general video devices and personal computer hardware. The techniques of digital video and digital image processing such as template matching, sub-pixel and motion estimate etc were employed to identify and trace the markers.

Total Synthesis of Tricolorin A.

Tricolorin A (1), a structurally amazing resin glycoside with promising bioactivities from Ipomoea tricolor cav. (convolvulaceae), was synthesized in a total of 45 steps, with the longest linear sequence of 20 steps and overall yield of 0.65% from D-mannitol.