Rutin Synergizes with Colistin to Eradicate Salmonellosis in Mice by Enhancing the Efficacy and Reducing the Toxicity.

The wide dissemination of multidrug-resistant (MDR) Gram-negative bacteria poses a significant global health and security concern. As developing new antibiotics is generally costly, fastidious, and time-consuming, there is an urgent need for alternative therapeutic strategies to address the gap in antibiotic discovery void. This study aimed to investigate the activity of colistin (CS) in combination with a natural product, rutin (RT), to combat against Typhimurium ( Tm) in vitro and in vivo.

The correlation between protein energy wasting and the incidence of main adverse cardiovascular events in adult maintenance hemodialysis patients: a single-center retrospective cohort study.

Background: Protein energy wasting (PEW) is prevalent in adult maintenance hemodialysis (MHD) patients. Concurrently, cardiovascular diseases (CVD) remain a leading cause of mortality in MHD patients. However, the relationship between PEW and CVD in MHD patients remains unclear.

Effect of curcumin regulated memory Th7 cells in mice with DSS-induced colitis.

Abnormal activation or dysfunction of memory helper T (mTh) cells is closely associated with the development of ulcerative colitis (UC). Curcumin (Cur), the main component of turmeric, plays a critical role in the treatment of UC due to its favorable anti-inflammatory and immunomodulatory bioactivities. However, whether Cur modulates mTh7 cells to alleviate UC is unknown.

Disturbed neurovascular coupling in patients with white matter hyperintensities: potential biomarker for cognitive impairment.

Purpose: To explore the neurovascular mechanisms of white matter hyperintensities (WMHs)-related cognitive impairment by introducing a neurovascular biomarker, neurovascular coupling (NVC).

Methods: We applied resting-state functional magnetic resonance imaging combined with arterial spin labeling to investigate the NVC dysfunctional patterns in patients with pure WMHs. Partial correlation, mediation, and exploratory subgroup analyses were adopted to explore the relationship among WMHs, NVC dysfunction, and cognitive decline.

Introducing different long-chain flexible ligands to regulate the transformation behavior of NiFe-MOF and as bifunctional catalysts for the HER/OER.

The investigation of highly efficient metal-organic framework (MOF) electrocatalysts represents a pivotal challenge in enhancing the overall efficiency of water electrolysis. In this study, we present a co-liganding method based on molecular regulation, in which succinic (s.a), adipic (a.

Fe-Doped NiS Induces Self-Reconstruction for Urea-Assisted Water Electrolysis Enhancement.

Urea oxidation reaction (UOR) is an attractive alternative anodic reaction to oxygen evolution reaction (OER) for its low thermodynamic potential (0.37 V vs RHE). A major challenge that prohibits its practical application is the six-electron transfer process during UOR, demanding enhancements in the catalytic activity.

Unveiling the future: Bibliometric analysis on the application of nanomaterials in osteoarthritis (2006-2023).

Background: As the population ages, the socio-economic impact of osteoarthritis (OA) is becoming increasingly significant. In recent years, there has been a growing focus on the design and development of nanomaterials for diagnosing and treating OA. This study aims to comprehensively evaluate the current status and trends in the application of nanomaterials in OA through bibliometric analysis and provide a review.

Catalyst-Free Dearomative Allylboration of Ketones with Benzo[]thiophenylmethyl Boronic Acids.

A novel approach to the dearomative allylboration of ketones with benzo[]thiophenylmethyl boronic acids has been developed. By leveraging the inherent reactivity of the boronic acid unit, this process occurs under mild reaction conditions without the need for a catalyst, leading to the efficient formation of homoallylic tertiary alcohols accompanied by the construction of three-dimensional sulfur-containing alicyclic scaffolds in high yields with excellent stereoselectivities.

Controlling charge migration and CO conversion through surface decoration of 2D-hydrotalcite on bismuth oxybromide for enhanced artificial photosynthesis.

Photocatalytic reduction of CO in pure HO media to produce chemicals presents an appealing avenue for simultaneously alleviating energy and environmental crises. However, the rapid recombination of photogenerated charge carriers presents a significant challenge in this promising field. Heterojunction engineering has emerged as an effective approach to address this dilemma.

LCZ696, an angiotensin receptor-neprilysin inhibitor, ameliorates epithelial-mesenchymal transition of peritoneal mesothelial cells and M2 macrophage polarization.

Aims: To investigate the effects and mechanisms of LCZ696, an angiotensin receptor-neprilysin inhibitor (ARNI), on epithelial-mesenchymal transition (EMT) of peritoneal mesothelial cells and on macrophage M2 polarization.

Methods: We examined the effects of LCZ696 in a 4.25% high glucose peritoneal dialysis fluid (PDF)-induced peritoneal fibrosis (PF) mouse model, and explored the mechanisms of LCZ696 on human peritoneal mesothelial cells (HPMCs) stimulated by TGF-β1 (5 ng/mL) and on Raw264.

Synthesis Ag-Hollandite by mild route for highly efficient ozone decomposition.

Catalytic ozone (O) decomposition is a promising technology for curbing indoor O pollution, whereas its application is limited by the stability and moisture resistance of heterogeneous catalysts. Ag-Hollandite is a capable solution, but its facile synthesis still lacks systematic investigation. In this study, Ag-Hollandite catalysts were prepared using AgMnO as the precursor by reflux (AMO-Re), hydrothermal (AMO-HT), and homogeneous (AMO-HR) methods, respectively.

Strategies of invasive snail Pomacea canaliculata during hibernation in rice fields of south China: effects of body size, sex, and soil depth.

Background: The invasive freshwater snail Pomacea canaliculata is an agricultural pest with a certain level of tolerance to abiotic stress. After the harvest of late rice, the snails usually burrow themselves into the soil surface layers to overwinter and pose a renewed threat to rice production in the following year. Revealing the response of snails to environmental stresses is crucial for developing countermeasures to control their damage and spread.

Association of preoperative antiviral treatment with incidences of post-hepatectomy liver failure in hepatitis B virus-related hepatocellular carcinoma.

Background: Post-hepatectomy liver failure (PHLF) is a common consequence of radical partial hepatectomy in hepatocellular carcinoma (HCC).

Aims: To investigate the relationship between preoperative antiviral therapy and PHLF, as well as assess the potential efficacy of hepatitis B virus (HBV) DNA level in predicting PHLF.

Methods: A retrospective study was performed involving 1301 HCC patients with HBV who underwent radical hepatectomy.

Epitaxial growth of BiTiO-BiPO Z-scheme heterojunction to promote carrier transfer for photocatalytic oxidation of NO.

The lack of compactness in heterojunction interfaces and poor charge separation is a great challenge in developing high-efficiency heterojunction photocatalysts. Herein, a novel BiTiO-BiPO heterojunction was successfully prepared for the first time by epitaxial growth of BiPO on the surface of BiTiO nanosheets. The optimized BiTiO-BiPO-0.

Ginseng extract improves pancreatic islet injury and promotes β-cell regeneration in T2DM mice.

Introduction: . (Araliaceae; Ginseng Radix et Rhizoma), a traditional plant commonly utilized in Eastern Asia, has demonstrated efficacy in treating neuro-damaging diseases and diabetes mellitus. However, its precise roles and mechanism in alleviating type 2 diabetes mellitus (T2DM) need further study.

Built-in electric field mediated S-scheme charge migration and Co-N4(II) sites in cobalt phthalocyanine/MIL-68(In)-NH heterojunction for boosting photocatalytic nitric oxide oxidation.

The efficiency of photocatalytic Nitric Oxide(NO) oxidation is limited by the lack of oxygen(O) active sites and poor charge carrier separation. To address this challenge, we developed a molecular Cobalt Phthalocyanine modified MIL-68(In)-NH photocatalyst with a robust Built-in electric field(BIEF). In the 2 % CoPc-MIN sample, the BIEF strength is increased by 3.

Effect of Metaldehyde on Survival, Enzyme Activities, and Histopathology of the Apple Snail (Lamarck 1822).

, as an invasive exotic species in Asia, can adversely affect crop yields, eco-environment, and human health. Application of molluscicides containing metaldehyde is one effective method for controlling . In order to investigate the effects of metaldehyde on adult snails, we conducted acute toxicological experiments to investigate the changes in enzyme activities and histopathology after 24 h and 48 h of metaldehyde action.

Dysfunction of neurovascular coupling in patients with cerebral small vessel disease: A combined resting-state fMRI and arterial spin labeling study.

Background: Cerebral small vessel disease (CSVD) closely correlates to cognitive impairment, but its pathophysiology and the neurovascular mechanisms of cognitive deficits were unclear. We aimed to explore the dysfunctional patterns of neurovascular coupling (NVC) in patients with CSVD and further investigate the neurovascular mechanisms of CSVD-related cognitive impairment.

Methods: Forty-three patients with CSVD and twenty-four healthy controls were recruited.

Innovative Delivery System Combining CRISPR-Cas12f for Combatting Antimicrobial Resistance in Gram-Negative Bacteria.

Antimicrobial resistance poses a significant global challenge, demanding innovative approaches, such as the CRISPR-Cas-mediated resistance plasmid or gene-curing system, to effectively combat this urgent crisis. To enable successful curing of antimicrobial genes or plasmids through CRISPR-Cas technology, the development of an efficient broad-host-range delivery system is paramount. In this study, we have successfully designed and constructed a novel functional gene delivery plasmid, pQ-mini, utilizing the backbone of a broad-host-range Inc.

Mucosa-associated lymphoid tissue lymphoma of the lacrimal gland: A case report and literature review.

Rationale: The most common subtype of primary lymphoma of the ocular adnexa is the mucosa-associated lymphoid tissue (MALT) subtype. MALT lymphoma of the lacrimal gland is relatively rare among the lacrimal gland tumors, and the early clinical symptoms are atypical, which can easily lead to misdiagnosis and missed diagnosis. Here, we report a case of MALT lymphoma of the lacrimal gland and explore its clinical manifestations, pathological characteristics, management, and pathogenesis, with the aim of helping clinicians gain an in-depth understanding of ocular adnexal MALT lymphoma.

Copper-Bearing Metal-Organic Framework with Mucus-Penetrating Function for the Multi-Effective Clearance of Mucosal Colonized .

colonizes over 50% of people worldwide. Biofilm formation through penetrating gastric mucus and resistance acquired by markedly reduces the efficacy of traditional antibiotics. The present triple therapy and bismuth-based quadruple therapy inevitably causes intestinal flora disturbance and fails to address the excessive -triggered inflammatory response.

The role of zyxin in signal transduction and its relationship with diseases.

This review highlighted the pivotal role of zyxin, an essential cell focal adhesions protein, in cellular biology and various diseases. Zyxin can orchestrate the restructuring and dynamic alterations of the cellular cytoskeleton, which is involved in cell proliferation, adhesion, motility, and gene transcription. Aberrant zyxin expression is closely correlated with tumor cell activity and cardiac function in both tumorigenesis and cardiovascular diseases.