A clinical pilot trial of an artificial intelligence-driven smart phone application of bowel preparation for colonoscopy: a randomized clinical trial.

Background: High-quality bowel preparation is paramount for a successful colonoscopy. This study aimed to explore the effect of artificial intelligence-driven smartphone software on the quality of bowel preparation.

Methods: Firstly, we utilized 3305 valid liquid dung images collected mobile phones as training data.

PDIA3 rs2788: An Independent Risk Factor for Hypertension and Its Interaction With Antihypertensive Medications.

Hypertension is a multifactorial condition influenced by both genetic and environmental factors. Protein disulfide isomerase family A member 3 (PDIA3) is a key endoplasmic reticulum protein which may contribute to increased blood pressure. However, the relationship between PDIA3 polymorphisms and hypertension remain unclear.

Power Production and Degradation of Pesticide Wastewater Through Microbial Fuel Cells with the Modified Activated Carbon Air Cathode by Hollow-Carbon and Carbon-Encapsulated Structures.

Microbial fuel cell (MFC) can degrade pesticide wastewater and recovery energy simultaneously, and the activated carbon (AC) air cathode has great prospects for practical application. However, insufficient active sites and the limitation of multi-step electron transfer for oxygen reduction reaction (ORR) requires that AC should be modified by highly efficient electrocatalysts. Herein, busing the confinement effect of carbon-encapsulated metal and hollow carbon, we designed a unique ORR catalyst of Fe-FeO-NC through utilizing the 2D leaf-like nanoplates of Zn-ZIF-L to load Prussian blue (PB) particles.

Construction of an electrochemical sensor based on magnetic molecularly imprinted polymer-zeolite imidazole framework-8 for detection of 3,4-benzopyrene.

A novel molecular-imprinted electrochemical sensor for 3,4-benzopyrene (3, 4-BaP) in food samples, with high sensitivity and selective detection, is introduced. Firstly, graphene oxide was modified onto a glassy carbon electrode (GCE) by electroreduction deposition to form an RGO/GCE sensing platform, thereby enhancing the sensitivity and stability of the sensor. Then, magnetic molecularly imprinted polymer-zeolite imidazole framework-8 (MMIP-ZIF-8) was synthesized in one step using the crystal growth method and modified onto RGO/GCE, endowing the sensor with good adsorption capacity and selectivity.

Bimetallic conductive molecular 2D metal-organic framework @ 2D MXene nanosheet heterostructure for lithium storage.

Two-dimensional metal-organic frameworks (2D MOFs) have been considered to be one type of potential cathodes for lithium storage due to their regular channels and devisable redox-active sites. However, the relatively low electrical conductivity and weak long-term cyclability hindered their development. Herein, we report an optimized bimetallic conductive 2D MOF (CoNi(HHTP)) for enhanced lithium-ion storage.

Chitosan-Promoted TiO-Loaded Double-Network Hydrogels for Dye Removal and Wearable Sensors.

The loading of photocatalysts on hydrogels can significantly reduce the loss of catalysts and effectively prevent secondary contamination, thus demonstrating great application potential and advantages in the field of wastewater treatment, especially in the removal of dyes. Herein, the semiconductor TiO was successfully loaded into a polyacrylic acid/chitosan (PAA/CS) double-network (DN) hydrogel, which exhibited superior removal of dyes in wastewater such as MG, MB, MV, and RhB. The dye degradation process followed first-order kinetics, and the first-order rate constants for dye degradation were further calculated under UV light irradiation.

Preventing postsurgical colorectal cancer relapse: A hemostatic hydrogel loaded with METTL3 inhibitor for CAR-NK cell therapy.

Colorectal cancer (CRC) recurrence post-surgery remains a major challenge. While Chimeric Antigen Receptor (CAR)-engineered natural killer (NK) cells hold immense therapeutic potential, their intratumoral infiltration ability remains limited, hampering efficacy. Building upon prior research suggesting that chemokines like C-X-C motif chemokine ligand 9 (CXCL9) and C-X-C motif chemokine ligand 10 (CXCL10) recruit CAR-NK cells, we hypothesized that tumor cell m6A methylation, regulated by Methyltransferase-like 3 (METTL3), influences chemokine secretion.

Ethyl palmitate ameliorates lethal endotoxemia by inducing hepatic fetuin-A secretion: an and experiment.

Background: Ethyl palmitate (EP) is known to promote hepatic fetuin-A production and modulate inflammatory responses, but its potential role in lethal endotoxemia and sepsis remains unclear. This study investigates the plasma fetuin-A levels and further evaluates the impact of hepatic fetuin-A induced by EP on systemic inflammation and macrophage polarization in lethal endotoxemia and sepsis.

Methods: Blood samples from 55 sepsis patients and 18 non-septic controls with similar age and sex ratio were collected to perform proteomic analyses and identify significantly different proteins.

Evaluating Medical Entity Recognition in Health Care: Entity Model Quantitative Study.

Background: Named entity recognition (NER) models are essential for extracting structured information from unstructured medical texts by identifying entities such as diseases, treatments, and conditions, enhancing clinical decision-making and research. Innovations in machine learning, particularly those involving Bidirectional Encoder Representations From Transformers (BERT)-based deep learning and large language models, have significantly advanced NER capabilities. However, their performance varies across medical datasets due to the complexity and diversity of medical terminology.

Pathophysiological dynamics in the contact, coagulation, and complement systems during sepsis: Potential targets for nafamostat mesilate.

Sepsis is a life-threatening syndrome resulting from a dysregulated host response to infection. It is the primary cause of death in the intensive care unit, posing a substantial challenge to human health and medical resource allocation. The pathogenesis and pathophysiology of sepsis are complex.

How do filter types of renal replacement therapy affect survival in critically ill patients? Concerns about adsorption of nafamostat mesylate on AN69 membranes.

We are writing to you in response to the article published in BMC Nephrology titled "Dose of nafamostat mesylate during continuous kidney replacement therapy in critically ill patients: a two-centre observational study". The study provided valuable information on the use of nafamostat mesylate (NM) during continuous renal replacement therapy (CRRT) in critically ill patients. We noticed in this study that a higher dose of NM resulted in a decrease in ICU and hospital mortality.