Correction: Hao et al. Enhanced Chemoprevention of Prostate Cancer by Combining Arctigenin with Green Tea and Quercetin in Prostate-Specific Phosphatase and Tensin Homolog Knockout Mice. 2024, , 105.

The authors would like to replace Figure 3B of the following published paper [...

Prediction of cognitive conversion within the Alzheimer's disease continuum using deep learning.

Background: Early diagnosis and accurate prognosis of cognitive decline in Alzheimer's disease (AD) is important to timely assignment to optimal treatment modes. We aimed to develop a deep learning model to predict cognitive conversion to guide re-assignment decisions to more intensive therapies where needed.

Methods: Longitudinal data including five variable sets, i.

Machine Learning-Driven Mass Discovery and High-Throughput Screening of Fluoroether-Based Electrolytes for High-Stability Lithium Metal Batteries.

Developing novel fluoroether electrolytes with high-voltage stability is an effective strategy to improve the performance of lithium metal batteries (LMB). However, the vast chemical space of fluoroether is underexplored due to the absence of effective tools to evaluate the potential used in high-voltage LMB. Herein, a framework was developed in combination of Voting ensemble algorithms and graph convolution neural network (GCNN), allowing the fast assessment of oxidative stability of non-aqueous liquid electrolytes, synthesizability of solvents as well as the solvation ability of them to dissolve lithium salts.

Intrinsic Structural and Coordination Chemistry Insights of Li Salts in Rechargeable Lithium Batteries.

Lithium batteries, favored for their high energy density and long lifespan, are staples in electric vehicles, portable electronics, and aerospace. A key component, Li salts, aids lithium ion migration and electrode protection, significantly impacting battery performance. Developing an ideal Li salt, balancing stability, solubility, dissociation, solvation, and eco-friendliness, remains challenging.

Compound lactic acid bacteria enhance the aerobic stability of Sesbania cannabina and corn mixed silage.

Background: The strategic delay of aerobic deterioration in Sesbania cannabina and corn (SC) mixed silage, coupled with effective fermentation, could increase the protein-rich silage utilization by ruminants. Thus, we sought to investigate the role of a compound lactic acid bacteria (LAB) inoculant (Lactobacillus plantarum + Lactobacillus farciminis + Lactobacillus buchneri + Lactobacillus hilgardii; at a level of 10 CFU/g fresh weight) in enhancing the aerobic stability of SC mixed silage. Specifically, we focused on the potential for corn supplementation to improve fermentation quality while concurrently increasing the susceptibility of SC mixed silage to aerobic spoilage.

Dengue Virus Replicative-Form dsRNA Is Recognized by Both RIG-I and MDA5 to Activate Innate Immunity.

RIG-I like receptors (RLRs) are a family of cytosolic RNA sensors that sense RNA virus infection to activate innate immune response. It is generally believed that different RNA viruses are recognized by either RIG-I or MDA5, two important RLR members, depending on the nature of pathogen-associated molecular patterns (PAMPs) that are generated by RNA virus replication. Dengue virus (DENV) is an important RNA virus causing serious human diseases.

Binary Metal Alloy Electrocatalyst Synergistically Accelerates the Bidirectional Polysulfide Conversions in Lithium-Sulfur Batteries.

The sluggish redox kinetics of polysulfides and the resulting shuttle effect remain significant challenges for the practical utilization of lithium-sulfur (Li-S) batteries. To address the unidirectional catalytic limitations of conventional electrocatalysts, we herein report a binary metal (CoNi) alloy embedded in a carbon matrix on carbon nanofibers (CoNi@C-CNFs) as a highly efficient electrocatalyst to accelerate bidirectional polysulfide conversions. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) reveals a significantly improved catalytic effect of the CoNi alloy toward polysulfide conversions after introducing the Ni component.

Enhancing catalytic activity in MoC nanodots via nitrogen doping and graphene integration for efficient hydrogen evolution under alkaline conditions.

Due to its exceptional electronic properties and catalytic activity, MoC has garnered significant attention for its application in electrocatalysis, particularly for the hydrogen evolution reaction (HER). However, several critical challenges continue to impede its widespread use, especially under strongly alkaline conditions. A primary obstacle is the enhancement of its intrinsic activity through further modification strategies, which remains a key limitation for its broader utilization.

Fermentation quality, amino acids profile, and microbial communities of whole-plant soybean silage in response to B90 alone or in combination with functional microbes.

Promoting the availability of silage with a high protein content on farms can lead to profitable and sustainable ruminant production systems. Whole plant soybean ( L. Merrill, WPS) is a promising high-protein forage material for silage production.

Metal-Organic Coordination Enhanced Metallopolymer Electrolytes for Wide-Temperature Solid-State Lithium Metal Batteries.

The practical application of polymer electrolytes is seriously hindered by the inferior Li ionic conductivity, low Li transference number (t), and poor interfacial stability. Herein, a structurally novel metallopolymer is designed and synthesized by exploiting a molybdenum (Mo) paddle-wheel complex as a tetratopic linker to bridge organic and inorganic moieties at molecular level. The prepared metallopolymer possesses combined merits of outstanding mechanical and thermal stability, as well as a low glass transition temperature (T <-50 °C).

LRJ-1 alleviates constipation through promoting gut -derived γ-aminobutyric acid production.

Multiple gastrointestinal disorders are associated with impaired gut microbiota. Probiotic can improve bowel disorder, however, the action mechanism is poorly understood. We integrated multi-omics data from the gut metagenome, metabolome, and colon transcriptome of constipated mice underlying LRJ-1 treatment to provide insights into host-microbial metabolic pathway.

Cytoskeletal Vimentin Directs Cell-Cell Transmission of Hepatitis C Virus.

Hepatitis C virus (HCV) is a major human pathogen causing liver diseases. Although direct-acting antiviral agents effectively inhibit HCV infection, cell-cell transmission remains a critical venue for HCV persistence in vivo. However, the underlying mechanism of how HCV spreads intercellularly remains elusive.

An Ultrahigh-Modulus Hydrogel Electrolyte for Dendrite-Free Zinc Ion Batteries.

Quasi-solid-state aqueous zinc ion batteries suffer from anodic zinc dendrite growth during plating/stripping processes, impeding their commercial application. The inhibition of zinc dendrites by high-modulus electrolytes has been proven to be effective. However, hydrogel electrolytes are difficult to achieve high modulus owing to their inherent high water contents.

Iodine Boosted Fluoro-Organic Borate Electrolytes Enabling Fluent Ion-Conductive Solid Electrolyte Interphase for High-Performance Magnesium Metal Batteries.

Rechargeable magnesium batteries are regarded as a promising multi-valent battery system for low-cost and sustainable energy storage applications. Boron-based organic magnesium salts with terminal substituent fluorinated anions (Mg[B(OR)], R=fluorinated alkyl) have exhibited impressive electrochemical stability and oxidative stability. Nevertheless, their deployment is hindered by the complicated synthesis routes and the surface passivation of Mg metal anode.

Flue-cured tobacco intercropping with insectary floral plants improves rhizosphere soil microbial communities and chemical properties of flue-cured tobacco.

Background: Continuous cropping of the same crop leads to land degradation. This is also called the continuous-cropping obstacle. Currently, intercropping tobacco with other crops can serve as an effective strategy to alleviate continuous cropping obstacles.

The role of pyroptosis in the occurrence and development of pregnancy-related diseases.

Pyroptosis is a form of programmed cell death that is crucial in the development of various diseases, including autoimmune diseases, atherosclerotic diseases, cancer, and pregnancy complications. In recent years, it has gained significant attention in national and international research due to its association with inflammatory immune overactivation and its involvement in pregnancy complications such as miscarriage and preeclampsia (PE). The mechanisms discussed include the canonical pyroptosis pathway of gasdermin activation and pore formation (caspase-1-dependent pyroptosis) and the non-canonical pyroptosis pathway (cysteoaspartic enzymes other than caspase-1).

Association of white matter hyperintensities with cognitive decline and neurodegeneration.

Background: The relationship between white matter hyperintensities (WMH) and the core features of Alzheimer's disease (AD) remains controversial. Further, due to the prevalence of co-pathologies, the precise role of WMH in cognition and neurodegeneration also remains uncertain.

Methods: Herein, we analyzed 1803 participants with available WMH volume data, extracted from the ADNI database, including 756 cognitively normal controls, 783 patients with mild cognitive impairment (MCI), and 264 patients with dementia.

Facile Redox Synthesis and Surface Engineering of Porous Silicon from Zintl Compound for High-Performance Lithium Ion Battery Anodes.

Porous silicon (pSi) is considered a promising candidate for next-generation high-energy-density lithium-ion battery (LIB) anodes due to its ability to mitigate volume expansion stress. However, the lack of efficient preparation methods and severe side reactions due to its large specific surface area have hindered its commercial development. This study leverages the redox reaction between the Zintl compound MgSi and SiO at certain temperatures, using intermediate products as templates, and incorporates CVD deposition to create carbon-coated porous silicon (pSi@C) composite anode materials with excellent electrochemical performance.

A prediction model of dementia conversion for mild cognitive impairment by combining plasma pTau181 and structural imaging features.

Aims: The early stages of Alzheimer's disease (AD) are no longer insurmountable. Therefore, identifying at-risk individuals is of great importance for precise treatment. We developed a model to predict cognitive deterioration in patients with mild cognitive impairment (MCI).

Advanced electrolytes for high-performance aqueous zinc-ion batteries.

Aqueous zinc-ion batteries (AZIBs) have garnered significant attention in the realm of large-scale and sustainable energy storage, primarily owing to their high safety, low cost, and eco-friendliness. Aqueous electrolytes, serving as an indispensable constituent, exert a direct influence on the electrochemical performance and longevity of AZIBs. Nonetheless, conventional aqueous electrolytes often encounter formidable challenges in AZIB applications, such as the limited electrochemical stability window and the zinc dendrite growth.

Rational Design of Quasi-1D Multicore-Shell MnSe@N-Doped Carbon Nanorods as High-Performance Anode Material for Sodium-Ion Batteries.

Sodium-ion batteries (SIBs) are considered one of the promising candidates for energy storage devices due to the low cost and low redox potential of sodium. However, their implementation is hindered by sluggish kinetics and rapid capacity decay caused by inferior conductivity, lattice deterioration, and volume changes of conversion-type anode materials. Herein, we report the design of a multicore-shell anode material based on manganese selenide (MnSe) nanoparticle encapsulated N-doped carbon (MnSe@NC) nanorods.

Pd(0)/Xantphos-Catalyzed Benzylic C(sp)-O Arylation of Benzyl Heteroaryl Ethers: Reduction of Pd(II) to Pd(0) by Xantphos.

Herein, we report the synthesis of 1,1-diarylmethanes via palladium-catalyzed benzylic C(sp)-O arylation of benzyl alcohol derivatives. An efficient, straightforward approach to synthesizing Pd(0)(xantphos) was developed through in situ reduction of Pd(II) to Pd(0) with the bidentate tertiary phosphine xantphos, which proved to be a highly active precatalyst in the Suzuki-Miyaura cross-coupling reaction of benzyl heteroaryl ethers.

Molecular Editing of Toluene by Sequential -C-H/Benzylic C-N Deaminative Functionalizations.

An approach to synthesizing structurally diverse toluene derivatives via sequential -C-H and benzylic C-N deaminative functionalization was developed by using a recyclable bifunctional directing template. The functionalized Katritzky salt intermediates are shown to be engaged in a wide range of carbon-carbon and carbon-heteroatom bond formation reactions. The synthetic utility of the strategy was demonstrated by late-stage functionalization of toloxatone.