'On Water'-Promoted Three-Component Tandem Michael Addition/D-A Cycloaddition Reaction to Construct Polycyclic N-Heterocycles Derivatives.

'On Water'-promoted the three-component tandem Michael addition/D-A cycloaddition reaction in 80 °C at 3 h has been developed without employing any catalyst and organic solvent. The process allows facile access to polycyclic N-heterocycles derivatives contain indole and maleimide from easily accessible starting materials in moderate to high yields (up to 91 %). Compared with conventional reaction conditions, this reaction not only improves the reaction efficiency and rate but also minimizes the side reaction.

Targeted isolation of prenylated indole alkaloids from the marine-derived fungus HK1‑6 using molecular networking.

Four prenylated indole alkaloids (-) were targeted isolated from the mangrove rhizosphere soil-derived fungus HK1-6 by using molecular networking strategies. Among them, the planar structure and relative configuration of notoamide X () were elucidated by detailed analysis of the spectroscopic data especially the NOESY spectrum for the first time and its absolute configuration was determined by ECD spectrum. Furthermore, curated molecular networks of MS/MS data were generated with GNPS which allowed highlighting six prenylated indole alkaloids (, , , , , ) that had not previously been identified in this fungus and two (, ) that had never been observed in any fungus.

Analysis of Outcome Indicators of Cancer-Related Fatigue Treated with Chinese Herbal Compounding.

Objective: In the direction of evaluating the current status of outcome indicators and control group selection in randomized controlled studies of Chinese herbal compounding (such as Sini plus Renshen Decoction, Jianpifuzhengfang, Bufei Jianzhong Decoction, etc) for cancer-caused fatigue and to provide a reference for clinical studies of Chinese herbal compounding for cancer-caused fatigue.

Methods: Randomized controlled studies of Chinese herbal medicine for cancer-caused fatigue in the midst of 2012 and 2022 were searched in CNKI, PubMed, and EMBASE databases on the China Knowledge Network, and the literature was screened using NoteExpress. Two researchers independently conducted the literature review, and then the studies that met the criteria were grouped and analyzed adopting qualitative analysis of outcome indicators and control groups.

Molecular mechanisms of Baihedihuang decoction as a treatment for breast cancer related anxiety: A network pharmacology and molecular docking study.

Background: The therapeutic effects of a combination of Chinese medicines called Baihedihuang decoction (BD) have been clinically verified, although its molecular targets in breast cancer related anxiety remain unknown.

Aim: To explore the molecular mechanisms of BD for breast cancer related anxiety treatment.

Methods: We used the Traditional Chinese Medicine Systems Pharmacology database to screen the active ingredients and potential targets of BD, and constructed the "drug-ingredient-target" network map with the help of Cytoscape 3.

Meta-analysis of gemcitabine plus nab-paclitaxel combined with targeted agents in the treatment of metastatic pancreatic cancer.

Background: Gemcitabine plus nab-paclitaxel (GA) is a commonly used first-line treatment regimen for metastatic pancreatic cancer, and many studies will add a novel targeted agent to this regimen for improving patient survival rate. However, the clinical effectiveness of GA is the most controversial issue.

Aim: To compare the efficacy and safety of GA regimen with a targeted agent and GA regimen.

Genomic analyses of wild argali, domestic sheep, and their hybrids provide insights into chromosome evolution, phenotypic variation, and germplasm innovation.

Understanding the genetic mechanisms of phenotypic variation in hybrids between domestic animals and their wild relatives may aid germplasm innovation. Here, we report the high-quality genome assemblies of a male Pamir argali ( , 2 = 56), a female Tibetan sheep ( , 2 = 54), and a male hybrid of Pamir argali and domestic sheep, and the high-throughput sequencing of 425 ovine animals, including the hybrids of argali and domestic sheep. We detected genomic synteny between Chromosome 2 of sheep and two acrocentric chromosomes of argali.

Metal-free synthesis of C2-quaternary indolinones by (NH)SO mediated oxidative dearomatization of indoles.

An efficient metal-free, (NH)SO mediated oxidative dearomatization of indoles for the construction of C2-quaternary indolinones was disclosed. A series of C2-quaternary indolinones derivatives with good functional group tolerance were obtained in moderate to excellent yields. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C2 position of indoles.

Diagnosis and guidance of treatment of breast cancer cutaneous metastases by multiple needle biopsy: A case report.

Background: Breast cancer patients have a high skin metastasis rate. However, reports on treatment of cutaneous metastases of breast cancer are scarce.

Case Summary: We report the treatment process for one breast cancer case with bone, lung, and skin metastases.

Clinical and genetic characteristics of two cases with Williams-Beuren syndrome.

Herein, we describe 2 cases of Williams-Beuren syndrome (WBS). In both cases, the patients exhibited mental retardation, characteristic facial features, and indirect inguinal hernia. Case 1, a girl aged 2 years and 5 months old, presented with hypercalcemia, and in case 2, a boy aged 4 years and 11 months old, the disorder manifested as infantile spasms, supravalvular aortic stenosis, and pulmonary stenosis.

Assembly of polycyclic N-heterocycles copper-catalyzed cycloamination of indolylquinones and aromatic amines.

The copper-catalyzed cycloamination of indolylquinones and various (hetero)aromatic amines under ligand-free conditions for the synthesis of polycyclic N-heterocycles has been developed. This method allows facile access to polycyclic N-heterocycles with the tolerance of chloride, bromide, amino, thio, etc. groups in moderate to high yields (60-89%).

Status and causes of soil compaction at apple orchards in the Weibei Dry Highland, Northwest China.

To find out the recessive factors of soil degradation threatening the healthy development of Weibei apple orchards, we examined soil compaction status and its inducing factors. This study could provide a theoretical basis for apple orchard scientific management. We evalua-ted the changes of soil bulk density and compaction with the depth of soil layer in 0-60 cm in four apple orchards with various planting period, including <10 years (4-6 years), 10-20 years (14-16 years) and ＞20 years (24-26 years).

Long noncoding RNA HAND2-AS1 reduced the viability of hepatocellular carcinoma via targeting microRNA-300/SOCS5 axis.

Background: Hepatocellular carcinoma (HCC) is one of the most prevalent human cancers with high mortality. Long non-coding RNA heart and neural crest derivatives expressed 2 anti-sense 1 (HAND2-AS1) is down-regulated in several cancers including HCC, yet the precise mechanisms how HAND2-AS1 regulates cell survival in HCC remains poorly understood.

Methods: The expression levels of HAND2-AS1 and miR-300 were measured using quantitative real-time PCR.

[Effects of Biochar Pyrolyzed at Varying Temperatures on Soil Organic Carbon and Its Components: Influence on the Composition and Properties of Humic Substances].

Application of biochar (BC) is an important way to increase soil organic carbon sequestration. At the same time, the effect of BC on fractions and properties of soil humic substances is concerned. A laboratory experiment was conducted to study the influences of BC pyrolyzed at different temperatures on the composition and properties of humic substances.

[Effects of Biochar Pyrolyzed at Varying Temperatures on Soil Organic Carbon and Its Components:Influence on the Soil Active Organic Carbon].

Soil active organic carbon is the most important carbon pool and a good indicator in ecosystem management due to its great significance in soil carbon cycling and soil quality.In order to investigate the effect of biochar (BC) addition on soil organic matter fractions,apple tree twigs were used to produce BC at 300,400,500 and 600℃,respectively.Elemental analysis and Fourier transform infrared (FTIR) spectroscopy were used to determine the characteristics of BC.

Simultaneous encapsulation of an infinite T4(0)A(0)6(0) water tape and discrete water hexamers in a hydrogen-bonded Ag(I) supramolecular framework.

Self-assembly of Ag2O, 1,4-bis(pyrid-4-yl)benzene (dpb) and 1,3-benzenedicarboxylic acid (H2bdc) resulted in a one-dimensional mixed-ligand Ag(I) coordination polymer [Ag2(dpb)2(bdc)·9H2O]n (1), in which infinite 1D T4(0)A(0)6(0) water tapes and discrete water hexamers were simultaneously encapsulated. Chair-like water hexamers and D2h water tetramers with two dangling water molecules were alternately hydrogen-bonded into the unprecedented 1D T4(0)A(0)6(0) water tape. Additionally, results on the thermal stability, UV-Vis absorption and photoluminescence spectra of 1 were discussed.

Non-coplanar 9,9-diphenyl-substituted oligofluorenes with large two-photon absorption enhancement.

The non-coplanar substituted phenyl rings at the 9-position of a fluorenyl unit can be involved in pi-electron delocalization in which the resulting oligofluorenes exhibit a very large enhancement of two-photon absorption cross sections up to 2559 GM at 710 nm.

Ambipolar diphenylamino end-capped oligofluorenylthiophenes as excellent electron-transporting emitters.

In addition to hole transport, diphenylamino-end-capped oligofluorenylthiophenes can exhibit efficient electron transport, in which the oligothiophene central core acts as an excellent electron-transporting moiety. The highly efficient undoped multilayer OLEDs using OF(2)TTP-NPh and OF(2)QTP-NPh as an electron-transporting emitter exhibited a maximum luminance of 19,800 and 11,800 cd m(-2) with a luminance efficiency up to 5.3 and 1.

Synthesis and light-emitting properties of bipolar oligofluorenes containing triarylamine and 1,2,4-triazole moieties.

A facile approach for synthesis of bipolar oligofluorenes, TAZ-OF(n)-NPh, n = 2 or 3 end-capped with hole-transporting diphenylamino and electron-transporting triazole moieties by Suzuki cross-coupling as the key reaction has been developed. This novel bipolar oligofluorenes exhibited blue-emission, high thermal and morphological stabilities. The single-layer OLED based on TAZ-OF(2)-NPh exhibited superior device performance with a maximum luminance of 1128 cd m(-2) and luminance efficiency of up to 0.

Synthesis and functional properties of end-dendronized oligo(9,9-diphenyl)fluorenes.

[structure: see text] A facile approach for the synthesis of a family of dendrimers OFn-EG with hole-transporting ability moieties by copper-catalyzed Buchwald's double-amination as a key reaction has been developed. These novel dendrimers exhibit good energy transfer efficiencies and very high thermal and electrochemical stabilities and have potential applications as hole transfer and emitting layers in the field of organic emitting diodes (OLEDs) or as host materials for electrophosphorescent applications.

Diphenylamino end-capped oligofluorenes with enhanced functional properties for blue light emission: synthesis and structure-property relationships.

A novel series of monodisperse asymmetrically and symmetrically substituted diphenylamino end-capped oligofluorenes, OF(2)-NPhR, R = H or An (An = 9-anthryl) and OF(n)-NPh, n = 2-4, has been synthesized by a convergent approach using palladium-catalyzed Suzuki cross-coupling. End-capping of oligofluorenes with diphenylamino group(s) has been shown to offer advantages in terms of lowering their first ionization potentials, enhancing thermal stability, and inducing good amorphous morphological stability. By tuning the number of diphenylamino end-caps and the chain length, the optimal conjugated length for optical and luminescence properties has been determined.

Synthesis and functional properties of strongly luminescent diphenylamino end-capped oligophenylenes.

Two novel homologous series of oligophenylenes (OPPs) symmetrically end-capped with diphenylamino groups and asymmetrically end-capped with anthryldiphenylamino groups were successfully synthesized by a convergent approach with use of palladium-catalyzed homo- and cross-coupling of arylboronic acids. The absorption maxima of both diphenylamino end-capped OPP series do not vary with the chain length although the molar absorptivities increase sequentially. On the other hand, the emission maxima slightly shift to longer wavelengths when the phenylene unit increases in the series.