A preliminary investigation of anti-reflux intervention for gastroesophageal reflux related childhood-to-adult persistent asthma.

Background: Childhood-to-adult persistent asthma is usually considered to be an atopic disease. However gastroesophageal reflux may also play an important role in this phenotype of asthma, especially when it is refractory to pulmonary medicine.

Methods: Fifty-seven consecutive GERD patients who had decades of childhood-to-adult persistent asthmatic symptoms refractory to pulmonary medication were enrolled.

Mesocavoatrial shunt for Budd-Chiari syndrome: a case report with long-term follow-up.

Background: A case of mesocavoatrial shunting for the treatment of Budd-Chiari syndrome (BCS) with long-term follow-up is reported.

Methods: A 25-year-old man with stage II BCS was treated with a mesocavoatrial shunt to decompress the portal and IVC hypertension. During the 6-year follow-up, the patient was able to resume work as a salesperson and has since led a normal life.

Surgical treatment of multivessel lesions in Takayasu's arteritis: report of a case.

Takayasu's arteritis (TA) is a chronic vasculitis involving the aorta and its main branches, the pulmonary arteries, and the coronary tree. Here we report a case of TA complicated by severe stenosis of the left coronary ostium with multivessel brachiocephalic involvement. A combination of these abnormalities could complicate underlying illness in patients, posing an increased risk of surgical morbidity.

Mesojugular shunt for Budd-Chiari syndrome: a case report with long-term follow-up.

Background: We report a case of a mesojugular shunt for Budd-Chiari syndrome (BCS) with long-term follow-up.

Methods: A 32-year-old woman presented with late stage BCS. She was treated with a mesojugular shunt to relieve her portal hypertension.

Reendothelialization of tubular scaffolds by sedimentary and rotative forces: a first step toward tissue-engineered venous graft.

Purpose: Uniform and tubular surface seeding is a prerequisite for tissue-engineered blood vessels to mature properly in a bioreactor. Our objective was to investigate reendothelialization of tubular scaffolds by the synergistic forces of sedimentation and rotation, so as to fabricate tissue-engineered venous grafts in vitro.

Materials And Methods: Canine bone-marrow-derived endothelial progenitor cells were expanded in vitro.

Single-branch endograft for treating stanford type B aortic dissections with entry tears in proximity to the left subclavian artery.

Purpose: To present a preliminary experience with a single-branch endograft for excluding Stanford type B aortic dissections with entry tears adjacent to the left subclavian artery (LSA).

Methods: From February to August 2004, 16 symptomatic patients (15 men; mean age 57.8 years, range 41-73) having a Stanford B aortic dissection with a proximal tear <15 mm from the LSA orifice were treated with a single-branch thoracic endograft constructed of Z-shaped nitinol stents to which a Dacron graft had been sutured.

Evolution of management for Budd-Chiari syndrome: a team's view from 2564 patients.

Aim: Exploring the development of therapy for a formerly rare and life-threatening disorder, Budd-Chiari syndrome (BCS).

Methods: From 1981 to 2003, 2677 patients with BCS were admitted including 2546 cases that underwent intervention. Therapeutic means included 170 membranotomies, 181 cavoatrial shunts, 312 mesoatrial shunts including mesocavoatrial shunt, 67 mesojugular shunts, 232 radical resections, 1289 PTA, and 295 miscellaneous procedures.

A series of heterocyclic inhibitors of phenylalanyl-tRNA synthetases with antibacterial activity.

A series of novel heterocyclic analogues have been synthesized and evaluated for their ability to inhibit phenylalanyl-t-RNA synthetases and act as antibacterial agents. Several analogues have good antibacterial activity against Staphylococcus aureus.

A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases.

We have identified a series of spirocyclic furan and pyrrolidine inhibitors of Enterococcus faecalis and Staphylococcus aureus phenylalanyl-tRNA synthetases. The most potent analogue 1b showed IC50=5 nM (E. faecalis PheRS) and IC50=2 nM (S.

Deployment of endograft in the ascending aorta to reverse type A aortic dissection.

Current surgery to treat acute type A aortic dissection involving an intimal tear in the ascending aorta consists of resection and replacement, but mortality is high. We report the case of a 46-year-old female patient with Marfan syndrome who presented with excruciating retrosternal pain and breathing distress after a bowel movement with stress. Magnetic resonance imaging and multicolour sonography showed type A aortic dissection extending from the aortic root to the right iliac artery, with intimal tears in the ascending aorta above the sinotubular junction, the distal arch beyond the left subclavian artery and the isthmic region.