Publications by authors named "Zhizhou Xu"

Being the core of the ejector refrigeration system, an ejector with a suitable mixer, conical-cylindrical or cylindrical, is key to high-energy-efficiency and low-carbon systems. To promote the scientific selection of mixers for ejectors based on the theoretical models that have been validated by experiments, the evolution laws of the entrainment ratios in the two types of ejectors are studied under various operating conditions. Furthermore, the influence mechanism of the mixer structures on the entrainment ratio of the ejector is elucidated by comparing the distribution characteristics of the entropy generation rate, pressure lift proportion, and entropy generation rate of the per-unit pressure lift in the two types of ejectors.

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Article Synopsis
  • Lymph node metastasis (LNM) is a significant factor in the treatment failure of nasopharyngeal carcinoma (NPC), and understanding its microenvironment is crucial for developing better therapies.
  • Researchers analyzed 47,618 single cells from NPC samples to explore the immune ecosystems and communication between cells in metastatic lymph nodes compared to primary tumors.
  • The study found distinct immune and epithelial cell characteristics associated with the progression of NPC, revealing important signaling pathways that could inform new treatment strategies for patients with LNM.
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Background: Growing evidence has revealed that m6A modification of long noncoding RNAs (lncRNAs) dynamically controls tumor stemness and tumorigenesis-related processes. However, the prognostic significance of m6A-related lncRNAs and their associations with stemness in low-grade glioma (LGG) remain to be clarified.

Methods: A multicenter transcriptome analysis of lncRNA expression in 1,247 LGG samples was performed in this study.

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Heat-stable antifungal factor (HSAF), produced by OH11, is regarded as a potential biological pesticide due to its broad-spectrum antifungal activity and novel mode of action. However, the current production of HSAF is low and cannot meet the requirements for large-scale production. Herein, we discovered that iron ions greatly promoted HSAF production, and the ferric uptake regulator (Fur) was involved in this regulatory process.

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Background: Forkhead box (FOX) proteins belong to one of the largest transcription factor families and play crucial roles in the initiation and progression of cancer. Prior research has linked several FOX genes, such as FOXA1 and FOXM1, to the crucial process of carcinogenesis. However, the overall picture of FOX gene family across human cancers is far from clear.

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Myxin, a di--oxide phenazine isolated from the soil bacterium Lysobacter antibioticus, exhibits potent activity against various microorganisms and has the potential to be developed as an agrochemical. Antibiotic-producing microorganisms have developed self-resistance mechanisms to protect themselves from autotoxicity. Antibiotic efflux is vital for such protection.

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Glioblastomas are the most common and malignant central nervous system (CNS) tumors that occupied a highly heterogeneous tumor microenvironment (TIME). Long noncoding RNAs (lncRNAs), whose expression can be modified by DNA methylation, are emerging as critical regulators in the immune system. However, knowledge about the epigenetic changes in lncRNAs and their contribution to the immune heterogeneity of glioma is still lacking.

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Avoiding the host defence system is necessary for the survival of pathogens. However, the mechanisms by which pathogenic bacteria sense and resist host defence signals are still unknown. Sulforaphane (SFN) is a secondary metabolite of crucifers.

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Chromatin regulators (CRs) regulate the gene transcription process through combinatorial patterns, which currently remain obscure for pan-cancer. This study identified the interaction of CRs and constructed CR-CR interaction networks across five tumor cell lines. The global interaction analysis revealed that CRs tend to function in synergistically.

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pv. () is a Gram-negative bacterium that causes bacterial leaf blight in rice. In this study, we identified a putative TrpR-like protein, PXO_TrpR (PXO_00831), in .

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Article Synopsis
  • Sulforaphane (SFN), a secondary metabolite found in cruciferous plants, inhibits the growth and virulence of Xanthomonas species, which are known plant pathogens.
  • This inhibition occurs by targeting the OxyR transcription factor, impairing its ability to activate genes that help the bacteria cope with oxidative stress, an important factor for their survival during plant infections.
  • The study's findings suggest potential applications for SFN as a biopesticide, highlighting its role in enhancing plant defenses against Xanthomonas infections.
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Background: N6-methyladenosine (m A) plays an essential role in tumorigenesis and cancer progression. Long noncoding RNAs (lncRNAs) are discovered to be important targets of m A modification, and they play fundamental roles in diverse biological processes. However, there is still a lack of knowledge with regards to the association between m A and lncRNAs in human tumors.

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An accumulating body of research indicates that long-noncoding RNAs (lncRNAs) regulate the target genes and act as competitive endogenous RNAs (ceRNAs) playing an indispensable role in lung adenocarcinoma (LUAD). LUAD is frequently accompanied by the feature of chromosomal instability (CIN); however, CIN-related ceRNAs have not been investigated yet. We systematically analyzed and integrated CIN-related dysregulated ceRNAs characteristics in LUAD samples for the first time.

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Human papillomavirus (HPV) is a common virus, and about 5% of all cancers worldwide is caused by persistent high-risk HPV infections. Here, we reported a comprehensive analysis of the molecular features for HPV-related cancer types using TCGA (The Cancer Genome Atlas) data with HPV status. We found that the HPV-positive cancer patients had a unique oncogenic process, tumor microenvironment, and drug response compared with HPV-negative patients.

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Numerous studies have demonstrated that lncRNAs could compete with other RNAs to bind miRNAs, as competing endogenous RNAs (ceRNAs), to regulate each other. On the other hand, ceRNAs were found to be recurrently dysregulated in cancer status. However, limited studies considered the upstream epigenetic regulatory factors that disrupted the normal competing mechanism.

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