Regulatory factor X-5/SCL/TAL1 interruption site axis promotes aerobic glycolysis and hepatocellular carcinoma cell stemness.

The incidence and development of various tumors, such as hepatocellular carcinoma (HCC), are linked to tumor stem cells. Although research has revealed how important SCL/TAL1 interruption site (STIL) is in many human tumors, the impact of STIL on HCC stem cells is poorly understood. This study aimed to examine the regulatory mechanisms and the function of STIL in the stemness of HCC tumor cells.

Screening and quantification of pesticides in wetland water, ice, sediment and soil: Occurrence, transport and risk assessment.

Current researches on pesticides in wetlands are limited in terms of screening and quantification of many types of pesticides. Understanding the spatial and temporal dynamics, distribution patterns, and environmental risks of pesticides in multiple media is important for wetland ecological conservation. In this study, 222 pesticides were determined in multimedia samples collected simultaneously from the Songhua Wetland during four seasons.

Multi-Fingerprints Indoor Localization for Variable Spatial Environments: A Naive Bayesian Approach.

Fingerprint-based indoor localization has been a hot research topic. However, the current fingerprint-based indoor localization approaches still rely on a single fingerprint database, where the average level of data at reference points is used as the fingerprint representation. In variable environmental conditions, the variations in signals caused by changes in the environmental states introduce significant deviations between the average level and the actual fingerprint characteristics.

Bisphosphonium cation based metal halide glass scintillators with tunable melting points.

Organic-inorganic metal halide (OIMH) glass offers the advantages of large-scale production, high transparency, and minimal light scattering. However, undesired crystallization in OIMH glass can occur, leading to deteriorated transparency. Herein, a series of bisphosphonium organic cations were designed to construct Mn-based metal halide crystals with a photoluminescence quantum yield (PLQY) near unity, alongside the development of highly thermally stable OIMH glasses.

Uni-to-Multi Modal Knowledge Distillation for Bidirectional LiDAR-Camera Semantic Segmentation.

Combining LiDAR points and images for robust semantic segmentation has shown great potential. However, the heterogeneity between the two modalities (e.g.

Novel analysis of functional relationship linking moyamoya disease to moyamoya syndrome.

Objective: The aim of this study was to elucidate the genetic pathways associated with Moyamoya disease (MMD) and Moyamoya syndrome (MMS), compare the functional activities, and validate relevant related genes in an independent dataset.

Methods: We conducted a comprehensive search for genetic studies on MMD and MMS across multiple databases and identified related genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichments analyses were performed for these genes.

A High-Resolution Multipath Delay Measurement Method Using KFSC-WRELAX Algorithm.

Given the challenges associated with the low accuracy, complexity of the equipment, and poor interference resistance observed in current wireless multipath channel measurements, this study introduces a novel algorithm called KFSC-WRELAX. This algorithm integrates techniques involving pseudorandom noise (PN) sequences, Kalman filtering (KF), sliding correlation, and weighted Fourier transform combined with the RELAXation (WRELAX) algorithm. An m-sequence is employed as the probing sequence for channel detection.

Association of Genetically Predicted Anxiety and Depression With Functional Outcome After Ischemic Stroke: A Mendelian Randomization Study.

Background And Objectives: Anxiety and depression have implications for ischemic stroke recovery. This study explored the association of genetically predicted anxiety and depression with functional outcome after ischemic stroke using Mendelian randomization (MR) approach.

Methods: Independent genetic variants associated with anxiety and depression at genome-wide significance level ( < 5 × 10) were obtained from large-scale genome-wide association studies (N = 1,306,354).

Study on the Pumping Performance and Structure Parameters Optimization of High-Speed Small Compound Molecular Pump.

A molecular pump is the core component of vacuum systems in portable mass spectrometers and other analytical instruments. The forms of the existing molecular pumps mainly are the combinations of vertical bleed and compression channel, which have the shortcomings of heavy mass and large volume, which seriously restricts the application and development of portable mass spectrometers. Aiming at the problems of low strength and insufficient pumping performance under the miniaturization constraints (mass of 1.

Root suberization in the response mechanism of melon to autotoxicity.

Continuous cropping obstacles poses significant challenges for melon cultivation, with autotoxicity being a primary inducer. Suberization of cells or tissues is a vital mechanism for plant stress response. Our study aimed to elucidate the potential mechanism of root suberization in melon's response to autotoxicity.

MiR-150-5p Alleviates Renal Tubule Epithelial Cell Fibrosis via the Inhibition of Epithelial-Mesenchymal Transition by Targeting ZEB1.

Introduction: Although microRNA (miR)-150-5p participates in the progression of renal fibrosis, its mechanism of action remains elusive.

Methods: A mouse model of unilateral ureteral obstruction was used. The in vitro renal fibrosis model was established by stimulating human kidney 2 (HK-2) cells with transforming growth factor beta 1 (TGF-β1).

Enhancing barley yield potential and germination rate: gene editing of HvGA20ox2 and discovery of novel allele sdw1.ZU9.

Several dwarf and semi-dwarf genes have been identified in barley. However, only a limited number have been effectively utilized in breeding programs to cultivate lodging resistant varieties. This is due to the common association of dwarf and semi-dwarf traits with negative effects on malt quality.

Combined effects of micron-sized polyvinyl chloride particles and copper on seed germination of perilla.

Microplastics (MPs) and copper (Cu) pollution coexist widely in cultivation environment. In this paper, polyvinyl chloride (PVC) were used to simulate the MPs exposure environment, and the combined effects of MPs + Cu on the germination of perilla seeds were analyzed. The results showed that low concentrations of Cu promoted seed germination, while medium to high concentrations exhibited inhibition and deteriorated the morphology of germinated seeds.

Combined effect of freshwater salinization and harmful algae on the benthic invertebrate Chironomus pallidivittatus.

Global climate change as well as human activities have been reported to increase the frequency and severity of both salinization and harmful algal blooms (HABs) in many freshwater systems, but their co-effect on benthic invertebrates has rarely been studied. This study simultaneously examined the joint toxicity of salinity and different cyanobacterial diets on the behavior, development, select biomarkers, and partial life cycle of Chironomus pallidivittatus (Diptera). High concentrations of salts (e.

Selecting Monoclonal Cell Lineages from Somatic Reprogramming Using Robotic-Based Spatial-Restricting Structured Flow.

Somatic cell reprogramming generates induced pluripotent stem cells (iPSCs), which serve as a crucial source of seed cells for personalized disease modeling and treatment in regenerative medicine. However, the process of reprogramming often causes substantial lineage manipulations, thereby increasing cellular heterogeneity. As a consequence, the process of harvesting monoclonal iPSCs is labor-intensive and leads to decreased reproducibility.

Image Understands Point Cloud: Weakly Supervised 3D Semantic Segmentation via Association Learning.

Weakly supervised point cloud semantic segmentation methods that require 1% or fewer labels with the aim of realizing almost the same performance as fully supervised approaches have recently attracted extensive research attention. A typical solution in this framework is to use self-training or pseudo-labeling to mine the supervision from the point cloud itself while ignoring the critical information from images. In fact, cameras widely exist in LiDAR scenarios, and this complementary information seems to be highly important for 3D applications.

The mediating role of atrial fibrillation in causal associations between risk factors and stroke: a Mendelian randomization study.

Objectives: Atrial fibrillation (AF) contributes to stroke development and progression. We aimed to quantify the mediating role of AF in the causal associations between a wide range of risk factors and stroke via a Mendelian randomization (MR) framework.

Methods: We assessed the associations of 108 traits with stroke and its subtypes in a 2-sample univariable MR approach, then conducted a bidirectional MR analysis between these 108 traits and AF to evaluate the presence and direction of their causal associations.

Caffeic acid 3,4-dihydroxyphenethyl ester prevents colorectal cancer through inhibition of multiple cancer-promoting signal pathways in 1,2-Dimethylhydrazine/dextran sodium sulphate mouse model.

Objective: To elucidate the potential feature and mechanism of the caffeic acid 3,4-dihydroxyphenethyl ester (CADPE) molecule, which can prevent colorectal cancer (CRC) in the 1,2-Dimethylhydrazine (DMH)/dextran sodium sulphate (DSS)-induced mouse model.

Methods: Institute of cancer research (ICR) male mice were injected with 20 mg/kg DMH for a week. After that, 2% DSS was administered in the drinking water for another 7 d.

Adiposity and Functional Outcome After Ischemic Stroke: A Mendelian Randomization Study.

Background And Objectives: To investigate the causal relationships of abdominal adiposity (waist-to-hip ratio [WHR]) and overall adiposity (body mass index [BMI]) with functional outcome after ischemic stroke using Mendelian randomization.

Methods: Genetic instruments for WHR and BMI were obtained from the largest available genome-wide association studies meta-analysis of the Genetic Investigation of ANthropometric Traits consortium and the UK Biobank (N max = 806,834). Functional outcome after ischemic stroke was assessed using the modified Rankin Scale (mRS) score at 3-month after stroke onset, with mRS >2 (mRS 3-6) defined as an unfavorable functional outcome.

Variational Distillation for Multi-View Learning.

Information Bottleneck (IB) provides an information-theoretic principle for multi-view learning by revealing the various components contained in each viewpoint. This highlights the necessity to capture their distinct roles to achieve view-invariance and predictive representations but remains under-explored due to the technical intractability of modeling and organizing innumerable mutual information (MI) terms. Recent studies show that sufficiency and consistency play such key roles in multi-view representation learning, and could be preserved via a variational distillation framework.

MiR-150-5p Alleviates Renal Tubular Epithelial Cell Fibrosis by Activating Autophagy via β-catenin Signaling.

Objective: To verify whether miR-150-5p modulates the development of renal fibrosis and its mechanism.

Methods: Transforming growth factor (TGF)-β1 was implemented on HK-2 cells to construct a renal fibrosis model. Inhibition of autophagy was performed on HK-2 cells by treating with 3-methyladenine (3-MA, an inhibitor of autophagy).

Serum uric acid and prognosis of ischemic stroke: Cohort study, meta-analysis and Mendelian randomization study.

Introduction: The role of serum uric acid (UA) levels in the functional recovery of ischemic stroke remains uncertain. To evaluate whether UA could predict clinical outcomes in patients with ischemic stroke.

Patients And Methods: A three-stage study design was employed, combining a large-scale prospective cohort study, a meta-analysis and a Mendelian randomization (MR) analysis.

Positive-Negative Receptive Field Reasoning for Omni-Supervised 3D Segmentation.

Hidden features in the neural networks usually fail to learn informative representation for 3D segmentation as supervisions are only given on output prediction, while this can be solved by omni-scale supervision on intermediate layers. In this paper, we bring the first omni-scale supervision method to 3D segmentation via the proposed gradual Receptive Field Component Reasoning (RFCR), where target Receptive Field Component Codes (RFCCs) is designed to record categories within receptive fields for hidden units in the encoder. Then, target RFCCs will supervise the decoder to gradually infer the RFCCs in a coarse-to-fine categories reasoning manner, and finally obtain the semantic labels.