Publications by authors named "Zhiyun Xue"

Introduction: Deep learning (DL) has significantly advanced medical image classification. However, it often relies on transfer learning (TL) from models pretrained on large, generic non-medical image datasets like ImageNet. Conversely, medical images possess unique visual characteristics that such general models may not adequately capture.

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In an era of rapid advancements in artificial intelligence (AI) technologies, particularly in medical imaging and natural language processing, strategic efforts to leverage AI's capabilities in analyzing complex medical data and integrating it into clinical workflows have emerged as a key driver of innovation in healthcare [...

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Background: Large vision models (LVM) pretrained by large datasets have demonstrated their enormous capacity to understand visual patterns and capture semantic information from images. We proposed a novel method of knowledge domain adaptation with pretrained LVM for a low-cost artificial intelligence (AI) model to quantify the severity of SARS-CoV-2 pneumonia based on frontal chest X-ray (CXR) images.

Methods: Our method used the pretrained LVMs as the primary feature extractor and self-supervised contrastive learning for domain adaptation.

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Article Synopsis
  • Ovarian aging impacts the overall aging of the body, suggesting a link between reproductive health and general health as we age.
  • Metabolic disorders are identified as a significant factor influencing the aging of ovaries, indicating that metabolism and reproductive health are interconnected.
  • The article discusses recent developments in understanding how metabolic regulation affects ovarian aging and addresses critical topics within this research area.
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For deep learning-based machine learning, not only are large and sufficiently diverse data crucial but their good qualities are equally important. However, in real-world applications, it is very common that raw source data may contain incorrect, noisy, inconsistent, improperly formatted and sometimes missing elements, particularly, when the datasets are large and sourced from many sites. In this paper, we present our work towards preparing and making image data ready for the development of AI-driven approaches for studying various aspects of the natural history of oral cancer.

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Deep learning (DL) has demonstrated its innate capacity to independently learn hierarchical features from complex and multi-dimensional data. A common understanding is that its performance scales up with the amount of training data. However, the data must also exhibit variety to enable improved learning.

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We proposed a self-supervised machine learning method to automatically rate the severity of pulmonary edema in the frontal chest X-ray radiographs (CXR) which could be potentially related to COVID-19 viral pneumonia. For this we use the modified radiographic assessment of lung edema (mRALE) scoring system. The new model was first optimized with the simple Siamese network (SimSiam) architecture where a ResNet-50 pretrained by ImageNet database was used as the backbone.

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Model initialization techniques are vital for improving the performance and reliability of deep learning models in medical computer vision applications. While much literature exists on non-medical images, the impacts on medical images, particularly chest X-rays (CXRs) are less understood. Addressing this gap, our study explores three deep model initialization techniques: Cold-start, Warm-start, and Shrink and Perturb start, focusing on adult and pediatric populations.

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Deep learning (DL) has demonstrated its innate capacity to independently learn hierarchical features from complex and multi-dimensional data. A common understanding is that its performance scales up with the amount of training data. Another data attribute is the inherent variety.

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Lung segmentation in chest X-rays (CXRs) is an important prerequisite for improving the specificity of diagnoses of cardiopulmonary diseases in a clinical decision support system. Current deep learning models for lung segmentation are trained and evaluated on CXR datasets in which the radiographic projections are captured predominantly from the adult population. However, the shape of the lungs is reported to be significantly different across the developmental stages from infancy to adulthood.

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Cervical cancer is a significant disease affecting women worldwide. Regular cervical examination with gynecologists is important for early detection and treatment planning for women with precancers. Precancer is the direct precursor to cervical cancer.

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Artificial Intelligence (AI)-based medical computer vision algorithm training and evaluations depend on annotations and labeling. However, variability between expert annotators introduces noise in training data that can adversely impact the performance of AI algorithms. This study aims to assess, illustrate and interpret the inter-annotator agreement among multiple expert annotators when segmenting the same lesion(s)/abnormalities on medical images.

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Domain shift is one of the key challenges affecting reliability in medical imaging-based machine learning predictions. It is of significant importance to investigate this issue to gain insights into its characteristics toward determining controllable parameters to minimize its impact. In this paper, we report our efforts on studying and analyzing domain shift in lung region detection in chest radiographs.

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Deep learning (DL) models are state-of-the-art in segmenting anatomical and disease regions of interest (ROIs) in medical images. Particularly, a large number of DL-based techniques have been reported using chest X-rays (CXRs). However, these models are reportedly trained on reduced image resolutions for reasons related to the lack of computational resources.

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Deep learning (DL) models are state-of-the-art in segmenting anatomical and disease regions of interest (ROIs) in medical images. Particularly, a large number of DL-based techniques have been reported using chest X-rays (CXRs). However, these models are reportedly trained on reduced image resolutions for reasons related to the lack of computational resources.

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Research in Artificial Intelligence (AI)-based medical computer vision algorithms bear promises to improve disease screening, diagnosis, and subsequently patient care. However, these algorithms are highly impacted by the characteristics of the underlying data. In this work, we discuss various data characteristics, namely , and that impact the design, reliability, and evolution of machine learning in medical computer vision.

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Small ruler tapes are commonly placed on the surface of the human body as a simple and efficient reference for capturing on images the physical size of a lesion. In this paper, we describe our proposed approach for automatically extracting the measurement information from a ruler in oral cavity images which are taken during oral cancer screening and follow up. The images were taken during a study that aims to investigate the natural history of histologically defined oral cancer precursor lesions and identify epidemiologic factors and molecular markers associated with disease progression.

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Developments in deep learning techniques have led to significant advances in automated abnormality detection in radiological images and paved the way for their potential use in computer-aided diagnosis (CAD) systems. However, the development of CAD systems for pulmonary tuberculosis (TB) diagnosis is hampered by the lack of training data that is of good visual and diagnostic quality, of sufficient size, variety, and, where relevant, containing fine region annotations. This study presents a collection of annotations/segmentations of pulmonary radiological manifestations that are consistent with TB in the publicly available and widely used Shenzhen chest X-ray (CXR) dataset made available by the U.

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Image quality control is a critical element in the process of data collection and cleaning. Both manual and automated analyses alike are adversely impacted by bad quality data. There are several factors that can degrade image quality and, correspondingly, there are many approaches to mitigate their negative impact.

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Article Synopsis
  • Automated segmentation of TB lesions in chest X-rays using deep learning can enhance radiologist efficiency and improve clinical decision-making.
  • The study focuses on the advantages of using detailed annotations instead of broad bounding boxes, which helps minimize errors in pixel-level segmentation.
  • Results indicate that using a stacking ensemble approach leads to better segmentation performance compared to other methods, marking a significant advancement in fine-grained TB lesion identification.
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Intelligent computer-aided algorithms analyzing photographs of various mouth regions can help in reducing the high subjectivity in human assessment of oral lesions. Very often, in the images, a ruler is placed near a suspected lesion to indicate its location and as a physical size reference. In this paper, we compared two deep-learning networks: ResNeSt and ViT, to automatically identify ruler images.

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Pneumonia is an acute respiratory infectious disease caused by bacteria, fungi, or viruses. Fluid-filled lungs due to the disease result in painful breathing difficulties and reduced oxygen intake. Effective diagnosis is critical for appropriate and timely treatment and improving survival.

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Article Synopsis
  • Deep learning methods excel in medical image segmentation, particularly with a focus on selecting the right loss function for optimal results.
  • It is crucial to quantify uncertainty in predictions to ensure trust in automated diagnostics, especially for medical applications.
  • This study utilizes a VGG16-based U-Net model and Monte Carlo Dropout to segment TB findings in chest X-rays, achieving superior performance with an optimal uncertainty threshold of 0.7 for referring uncertain cases.
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During a colposcopic examination of the uterine cervix for cervical cancer prevention, one or more digital images are typically acquired after the application of diluted acetic acid. An alternative approach is to acquire a sequence of images at fixed intervals during an examination before and after applying acetic acid. This approach is asserted to be more informative as it can capture dynamic pixel intensity variations on the cervical epithelium during the aceto-whitening reaction.

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The burden of cervical cancer disproportionately falls on low- and middle-income countries (LMICs). Automated visual evaluation (AVE) is a technology being considered as an adjunct tool for the management of HPV-positive women. AVE involves analysis of a white light illuminated cervical image using machine learning classifiers.

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