Hollow Au nanoparticles for single-molecule Raman spectroscopy a synergistic electromagnetic and chemical enhancement strategy.

Raman spectroscopy has demonstrated significant potential in molecular detection, analysis, and identification, particularly when it adopts single-molecule surface-enhanced Raman scattering (SM-SERS) substrates. A recent SM-SERS scheme incorporates two-fold Raman enhancement mechanisms: the electromagnetic enhancement enabled by a plasmonic nanogap hotspot formed from gold sphere nanoparticles sitting on a gold mirror and the chemical enhancement enabled by a two-dimensional material, WS, inserted into the nanogap. In this work we integrate multiple advanced concepts and techniques to achieve remarkable performance improvements of SM-SERS.

Search for MeV-Scale Axionlike Particles and Dark Photons with PandaX-4T.

Axionlike particles (ALPs) and dark photons (DPs) are viable dark matter particle candidates. We have searched for possible ALP/DP signals in the PandaX-4T liquid xenon detector using 440  kg·yr of data. A binned likelihood fit is constructed to search for possible mono-energetic peaks induced by the absorption processes between ALPs/DPs and atomic electrons of xenon.

Nintedanib abrogates patient vitreous-induced Akt activation and tube formation of human retinal microvascular endothelial cells.

Growth factors and cytokines in the vitreous are critical drivers of proliferative diabetic retinopathy (PDR), a condition in which many patients exhibit resistance to current therapies. PDR is characterized by the formation of fibrovascular membranes on the vitreous side of the retina, which, if untreated, can lead to retinal detachment. Nintedanib, a clinically approved drug for idiopathic pulmonary fibrosis, targets multiple tyrosine kinases, including vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs), and fibroblast growth factor receptors (FGFRs).

Theranostic Rhenium Complexes as Suborganelle-Targeted Copper Ionophores To Stimulate Cuproptosis for Cancer Immunotherapy.

Being a recently identified mode of programmed cell demise, the functional implications of cuproptosis in the genesis, progression, and therapeutic modulation of cancer remain largely unknown. Given that cuproptosis is predominantly elicited by cellular copper overload, notably attributable to the dysregulation of copper homeostasis within mitochondria, we designed a series of phosphorescent rhenium(I) complexes (-) as suborganelle-targeted copper ionophores. Among them, can successfully transport extracellular copper into mitochondria and the Golgi apparatus and especially enrich copper into mitochondria.

Tribo and Corrosion Resistance of Ni-W-P Coatings Synergistically Enhanced by Cationic hBN and Cationic cBN.

In this work, polydopamine (PDA) modification of hBN is used to create DRhBN particles having a two-dimensional lamellar structure, which are then applied on Ni-W-P coatings. Additionally, pulsed electrodeposition is used to successfully create composite coatings of Ni-W-P/DRhBN, Ni-W-P/DRcBN, and Ni-W-P/DRhBN-DRcBN. The properties of the four composite coatings are contrasted.

Exploring New Physics with PandaX-4T Low Energy Electronic Recoil Data.

New particles beyond the standard model of particle physics, such as axions, can be effectively searched through their interactions with electrons. We use the large liquid xenon detector PandaX-4T to search for novel electronic recoil signals induced by solar axions, neutrinos with anomalous magnetic moment, axionlike particles, dark photons, and light fermionic dark matter. A detailed background model is established using the latest datasets with 1.

Di-Dang-Tang suppresses ferroptosis in the hippocampal CA1 region by targeting PGK1/NRF2/GPX4 signaling pathway to exert neuroprotection in vascular dementia.

Increasing evidence has emphasized the crucial role of ferroptosis in the pathogenesis of Vascular dementia (VaD). Di-Dang-Tang (DDT) has the effects of removing blood stasis according to the theory of Traditional Chinese medicine (TCM), while its effects on ferroptosis and mechanisms remain unclear. To elucidate whether the neuroprotective effect of DDT treatment is associated with ferroptosis mediated by the Phosphoglycerate kinase 1 (PGK1)/ Nuclear Factor Erythroid 2-related factor (NRF2)/ Glutathione Peroxidase 4 (GPX4) signaling pathway in the hippocampal CA1 region of rats with the 2-vessel occlusion (2VO) model, we conducted a series of experiments.

Giant Vortex Dichroism in Simplified-Chiral-Double-Elliptical Metamaterials.

Vortex dichroism in chiral metamaterials is of great significance to the study of photoelectric detection, optical communication, and the interaction between light and matter. Here we propose a compact chiral metamaterials structure composed of two elliptical SiO rods covered with a Au film on a substrate to achieve a significant vortex-dichroism effect. Such a structure has different responses to a Laguerre-Gaussian beam carrying opposite-orbital angular momentum, resulting in giant vortex dichroism.

Dark Matter Search Results from 1.54 Tonne·Year Exposure of PandaX-4T.

In this Letter, we report the dark matter search results from the commissioning run (Run0) and the first science run (Run1) of the PandaX-4T experiment. The two datasets were processed with a unified procedure, with the Run1 data treated blindly. The data processing is improved compared to previous work, unifying the low-level signal reconstruction in a wide energy range up to 120 keV.

Physical unclonable in-memory computing for simultaneous protecting private data and deep learning models.

Compute-in-memory based on resistive random-access memory has emerged as a promising technology for accelerating neural networks on edge devices. It can reduce frequent data transfers and improve energy efficiency. However, the nonvolatile nature of resistive memory raises concerns that stored weights can be easily extracted during computation.

Prediction of early postoperative recurrence of hepatocellular carcinoma by habitat analysis based on different sequence of contrast-enhanced CT.

Aim: To develop a habitat imaging method for preoperative prediction of early postoperative recurrence of hepatocellular carcinoma.

Methods: A retrospective cohort study was conducted to collect data on 344 patients who underwent liver resection for HCC. The internal subregion of the tumor was objectively delineated and the clinical features were also analyzed to construct clinical models.

Upregulating lncRNA GUSBP11 protects chondrocytes from IL-1β-induced inflammatory damage via inhibiting miR-122-5p.

Studies have demonstrated that several lncRNAs exhibit abnormal expression levels in patients suffering from osteoarthritis, and in-depth investigation of these aberrantly expressed lncRNAs may pave the way for innovative therapeutic strategies targeting OA. The aim of this study was to examine the expression of glucuronidase beta pseudogene 11 (GUSBP11) in OA patients and to elucidate its potential molecular mechanism. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was used to detect GUSBP11 levels on cartilage tissues and serum samples obtained from OA patients.

Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks.

Bacterial social interactions play crucial roles in various ecological, medical, and biotechnological contexts. However, predicting these interactions from genome sequences is notoriously difficult. Here, we developed bioinformatic tools to predict whether secreted iron-scavenging siderophores stimulate or inhibit the growth of community members.

Quantum Circuit Architecture Search on a Superconducting Processor.

Variational quantum algorithms (VQAs) have shown strong evidence to gain provable computational advantages in diverse fields such as finance, machine learning, and chemistry. However, the heuristic ansatz exploited in modern VQAs is incapable of balancing the trade-off between expressivity and trainability, which may lead to degraded performance when executed on noisy intermediate-scale quantum (NISQ) machines. To address this issue, here, we demonstrate the first proof-of-principle experiment of applying an efficient automatic ansatz design technique, i.

Formation and Magnetic Properties of Transition Metal Atomic Chains on Monolayer MoS Grain Boundaries: A First-Principles Study.

Magnetic one-dimensional nanostructures show great potential in spintronics and can be used as basic building blocks for magnetic materials and devices with multiple functions. In this study, transition group atomic chains (V, Cr, Mn, Fe, Co, and Ni) are introduced into nonmagnetic MoS with a 4|8ud-type grain boundary. Based on first-principles calculations, the V atomic chains show good thermodynamic stability and can self-assemble along the grain boundary direction.

Theranostic Rhenium(I)-Based ER-Phagy Retardant Promotes Immunogenic Cell Death.

ER-phagy is a double-edged sword in the occurrence, development, and treatment of cancer; especially, its functions in immunotherapy are still unknown. In this work, we designed a theranostic Re complex () containing a BODIPY-derived ligand and a β-carboline ligand to target the endoplasmic reticulum (ER) and block ER-phagy at the late stages. Interestingly, as validated both in vitro and in vivo, ER-phagy blockage greatly enhances the capability of to induce immunogenic cell death (ICD).

Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.

Introduction: The effects of sex and apolipoprotein E (APOE)-Alzheimer's disease (AD) risk factors-on white matter microstructure are not well characterized.

Methods: Diffusion magnetic resonance imaging data from nine well-established longitudinal cohorts of aging were free water (FW)-corrected and harmonized. This dataset included 4741 participants (age = 73.

Foundation model of ECG diagnosis: Diagnostics and explanations of any form and rhythm on ECG.

We propose a knowledge-enhanced electrocardiogram (ECG) diagnosis foundation model (KED) that utilizes large language models to incorporate domain-specific knowledge of ECG signals. This model is trained on 800,000 ECGs from nearly 160,000 unique patients. Despite being trained on single-center data, KED demonstrates exceptional zero-shot diagnosis performance across various regions, including different locales in China, the United States, and other regions.

Synergistic Nonreciprocity of Linear and Nonlinear Optical Diffraction.

Linear optical diffraction of light is a basic natural phenomenon subject to a long history study and it obeys the well-known reciprocity in transport. In this work we report observation of synergistic nonreciprocal linear and nonlinear diffraction of a Ti:sapphire femtosecond laser beam against a periodic poled lithium niobate (PPLN) thin plate nonlinear grating with a front surface corrugated with a shallow grating of a depth only 67 nm and a smooth back surface. A high peak power pump laser beam shining upon the geometrically asymmetric nonlinear grating from either the front surface and back surface will both cause significant second-order nonlinear (2nd-NL) Raman-Nath diffraction and Cerenkov radiation, in addition to apparent linear optical diffraction and modest third-order nonlinear (3rd-NL) spectral broadening.

Naked-eye and fluorescence resonance energy transfer based ratiometric fluorescent probe for rapid, sensitive and selective detection of hydrazine and its applications in imaging of environmental samples and living systems.

Hydrazine, a compound recognized for its carcinogenic and genotoxic properties, presents a significant threat to human health via environmental exposure and drug metabolism. The detection of hydrazine is essential for safeguarding human health. However, a tool capable of accurately detecting hydrazine across diverse sample types, such as soil, water sources, and plant specimens contaminated by hydrazine leakage, as well as cells and live mice containing endogenously generated hydrazine from drug metabolism, is still lacking.

Research progress on animal models of peritoneal adhesion.

Peritoneal adhesion is a common complication of abdominal and pelvic surgery that can cause various clinical symptoms, including abdominal pain, intestinal obstruction, and female infertility, significantly impacting patient quality of life. Animal models of peritoneal adhesion are important tools for studying the mechanisms of adhesion formation and evaluating the effectiveness of prevention and treatment. Various methods for constructing animal models of peritoneal adhesion include physical injury, chemical injury, ischemia, infection, foreign body stimulation, and simulated surgery; however, none can fully simulate peritoneal adhesion in patients clinically.

Extended One-Way Waveguide States of Large-Area Propagation in Gyromagnetic Photonic Crystals.

We propose extended one-way waveguide states of large-area propagation in a photonic crystal waveguide consisting of two honeycomb gyromagnetic photonic crystals with opposite external magnetic fields. When the width of the waveguide is small enough, the edge states along both boundaries of the waveguide couple with each other strongly and thus create the so-called extended one-way waveguide states. Of note, this structure supports both even and odd extended states, which can be excited under different excitation conditions.