Publications by authors named "Zhiyuan Hu"

Herein, we developed a dual-factor recognition activatable probe, S1-F, which accurately lights up Bcl-2 and GSH dual-overexpressed cancer tissue with a superior tumor-to-normal tissue (T/N) ratio, highlighting the potential for this probe to be used in the visual diagnosis and imaging-guided surgery of cancer.

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Plant sterilants are used to control rodent populations due to their minimal environmental risk and other ethical considerations. However, their practical utilization is unsatisfactory due to high costs and processing difficulties. is a plant material that has shown the potential to inhibit the reproduction of , a species that causes serious damage to crops in the Dongting Lake region in China.

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Microplastics (MPs) and per- and polyfluoroalkyl substances (PFASs) are ubiquitous contaminants in environments, yet their co-occurrence and interactions remain insufficiently understood. In this study, we confirmed the concurrent presence of MPs and PFASs and their distinct distribution patterns in a wastewater treatment plant (WWTP) through a comprehensive sampling and analysis effort. Significant correlations ( < 0.

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Purpose: Assistive device non-use among individuals with disabilities is often attributed to issues in service provision and user satisfaction with assistive devices. However, systematic research on the service quality and satisfaction of assistive devices among disabled populations is lacking. Therefore, this study aims to analyze the service delivery and satisfaction of assistive devices among individuals with disabilities.

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In this study, several hydrogen-bonded arylamide foldamers (compounds 1-5) with the same degree of polymerization were designed and synthesized. The polyfluoroiodobenzene or iodoethynyl polyfluoroiodobenzene segment was modified as a halogen donor at the end of the monomer, and pyridine or pyridine oxynitride served as the corresponding halogen acceptor segment. The crystal structure of compound 1 indicates that the supramolecular double helices were constructed by stacking a P helix and an M helix in an antiparallel manner in the direction of intermolecular I⋅⋅⋅O-N halogen bonding.

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Total Quality Management (TQM) is instrumental in augmenting the quality and efficacy of healthcare service delivery, but a comprehensive evaluation of present and evolving TQM research trends within healthcare research articles is notably absent. This study provides an insightful view into the prevailing international scenarios and upcoming research frontiers in healthcare TQM research field, utilizing bibliometric mapping through VOSviewer. Drawing data from 360 publications in the Web of Science core citation database, it delineates a steady growth in the field over the last 30 years.

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Article Synopsis
  • This study examines the characteristics of soot particles from a heavy-duty diesel engine that uses different blends of waste cooking oil biodiesel (WCO) and petroleum diesel.
  • The findings indicate that as the percentage of biodiesel in the fuel increases, the fringe length of soot particles decreases, while their oxidation activity and oxygen-to-carbon ratio (O/C) first increase and then decrease along the exhaust treatment system.
  • Additionally, varying biodiesel blends affect the chemical composition and structure of soot, which can help in optimizing exhaust after-treatment systems for better performance.
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Strain gauge plays vital roles in various fields as structural health monitoring, aerospace engineering, and civil infrastructure. However, traditional flexible strain gauge inevitably brings the pseudo-signal caused by the substrate temperature effect and determines its accuracy. Here, we present an anisotropic composite substrate designed to modify the thermal expansion performance via Micro-electro-mechanical System (MEMS) technology, which facilitates the development of strain gauges that are minimally affected by substrate temperature-induced effect.

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Fossil fuel energy crisis and environmental pollution have initiated the scientific research on alternative fuels. Biodiesel (B100), gas to liquid (G100), and coal to liquid (C100) are superb selections to be substitutes for conventional diesel. To better investigate the emission characteristics of the alternative fuels mentioned above, a portable emission measurement system (PEMS) was used to carry out this study under real-world driving conditions.

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A series of progress has been made in the field of antimicrobial use of nanozymes due to their superior stability and decreased susceptibility to drug resistance. However, catalytically generated reactive oxygen species (ROS) are insufficient for coping with multidrug-resistant organisms (MDROs) in complex wound environments due to their low targeting ability and insufficient catalytic activity. To address this problem, chemically stable copper-gallic acid-vancomycin (CuGA-VAN) nanoneedles were successfully constructed by a simple approach for targeting bacteria; these nanoneedles exhibit OXD-like and GSH-px-like dual enzyme activities to produce ROS and induce bacterial cuproptosis-like death, thereby eliminating MDRO infections.

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Article Synopsis
  • Photoactivation can enhance the photoluminescence and photostability in CdSe/ZnS quantum dots, but it’s less reported in fluorescent carbon quantum dots (CQDs).
  • Nitrogen-doped carbon quantum dots (N-CQDs) were created using a simple method, and they demonstrated a significant boost in fluorescence quantum yield (up to 10 times) after just 10 minutes of UV light exposure.
  • This research suggests the potential for N-CQDs to serve as a low-cost UV light sensor, which can evaluate sunlight's UV intensity and test the effectiveness of sunscreen products against UV radiation.
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Background: China has entered the era of digital health care after years of reforms in the health care system. The use of digital technologies in healthcare services is rapidly increasing, indicating the onset of a new period. The reform of health insurance has also entered a new phase.

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This study develops a series of NBI-based acidochromic AIEgens engineered for ultra-wide acidochromic scope in self-reporting soft actuators, establishing the relationship between the photophysical properties and structural configurations of the AIEgens, further investigating their acidochromic behavior and fabricating acidity monitoring chips. The acidochromic behaviors were thoroughly investigated, and high-precision acidity monitoring chips were fabricated. We confirmed the protonation order of nitrogen atoms within the molecules and elucidated the acidochromic mechanisms through DFT and H NMR analyses.

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Article Synopsis
  • * A novel biphenyl scaffold compound was created, showing significantly better efficacy in inhibiting the Hsp70-Bim PPI and improved water solubility compared to previous inhibitors.
  • * The research identified Lys319 as a critical "hot spot" in the Hsp70-Bim interaction, providing valuable insights for future design of targeted therapies against CML.
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Metal-organic frameworks (MOFs) are metal-organic skeleton compounds composed of self-assembled metal ions or clusters and organic ligands. MOF materials often have porous structures, high specific surface areas, uniform and adjustable pores, high surface activity and easy modification and have a wide range of prospects for application. MOFs have been widely used.

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In this work, the B, N co-doped carbon dots (B, N-CDs) were synthesized via facile hydrothermal approach with 6-aminopyridine boronic acid as precursor. In addition to emitting intense blue luminescence when exposed to ultraviolet light, the prepared B, N-CDs displayed remarkable peroxidase-like activity, which could efficiently catalyze the oxidation of 3, 3', 5, 5' -tetramethylbenzidine (TMB) to blue ox-TMB in the presence of hydrogen peroxide (HO). Furthermore, the fluorescence intensity of B, N-CDs increased gradually upon the addition of HO.

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Alzheimer's disease (AD) starts decades before cognitive symptoms develop. Easily accessible and cost-effective biomarkers that accurately reflect AD pathology are essential for both monitoring and therapeutics of AD. Neurofilament light chain (NfL) levels in blood and cerebrospinal fluid are increased in AD more than a decade before the expected onset, thus providing one of the most promising blood biomarkers for monitoring of AD.

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Introduction: is a homothallic fungus that is used in the natural fermentation process of Chinese Fuzhuan tea and has been linked to the production of bioactive components. However, not much is known about the variations present in the fungus. To understand the variation of the dominant microorganism, , within dark tea, the present study investigated the genetic and morphological diversity of 70 collected across six provinces of China.

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Unlabelled: The integration of predictive, preventive, personalized, and participatory (P4) healthcare advocates proactive intervention, including dietary supplements and lifestyle interventions for chronic disease. Personal profiles include deep phenotypic data and genetic information, which are associated with chronic diseases, can guide proactive intervention. However, little is known about how to design an appropriate intervention mode to precisely intervene with personalized phenome-based data.

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Circulating tumor cells (CTCs) have significant clinical value in early tumor detection, dynamic monitoring and immunotherapy. CTC detection stands out as a leading non-invasive approach for tumor diagnostics and therapeutics. However, the high heterogeneity of CTCs and the occurrence of epithelial-mesenchymal transition (EMT) during metastasis pose challenges to methods relying on EpCAM-positive enrichment.

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Although possessing well-defined nanostructures and excellent multi-electron redox properties, polyoxometalate clusters have poor intrinsic electrical conductivity and are prone to aggregation due to large surface energy, which makes them difficult to be fully utilized when applying as electrode materials for lithium-ion batteries. In this paper, monodisperse KMnVO (MnV) clusters are achieved by rationally utilizing nano-sized high conductive carbon dots (CDs) as stabilizers. Benefiting from the fully exposed redox sites of MnV clusters (high utilization rate) and sufficient interfaces with carbon dots (extra interfacial energy storage), the optimized MnV/10CDs anode delivers a high discharge capacity up to 1348 mAh g at a current density of 0.

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Acute wounds are converted to chronic wounds due to advanced age and diabetic complications. Nanozymes catalyze ROS production to kill bacteria without causing drug resistance, while microneedles (MNs) can break through the skin barrier to deliver drugs effectively. Nanozymes can be intergrateded into MNs delivery systems to improve painless drug delivery.

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The association between dysfunctional microglia and amyloid-β (Aβ) is a fundamental pathological event and increases the speed of Alzheimer's disease (AD). Additionally, the pathogenesis of AD is intricate and a single drug may not be enough to achieve a satisfactory therapeutic outcome. Herein, we reported a facile and effective gene therapy strategy for the modulation of microglia function and intervention of Aβ anabolism by ROS-responsive biomimetic exosome-liposome hybrid nanovesicles (designated as TSEL).

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In this study, a series of H-bonded arylamide foldamers bearing benzoselenadiazole ends with solvent-responsive properties have been synthesized. In dichloromethane or dimethyl sulfoxide solvents, the molecules exhibit meniscus or linear structures, respectively, which can be attributed to the unique intramolecular hydrogen bonding behavior evidenced by 1D H NMR and 2D NOESY spectra. UV-vis spectroscopy experiments show that the absorption wavelength of H-bonded arylamide foldamers are significantly red-shifted due to the presence of benzoselenadiazole group.

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