Responsive β-Diketonate-europium(III) Complex-Based Probe for Time-Gated Luminescence Detection and Imaging of Hydrogen Sulfide and .

As a crucial biological gasotransmitter, hydrogen sulfide (HS) plays important roles in many pathological and physiological processes. Highly selective and sensitive detection of HS is significant for the precise diagnosis and evaluation of diverse diseases. Nevertheless, challenges remain in view of the interference of autofluorescence in organisms and the stronger reactivity of HS itself.

A strategy to enhance the water solubility of luminescent β-diketonate-Europium(III) complexes for time-gated luminescence bioassays.

Luminescent β-diketonate-europium(III) complexes have been found a wide range of applications in time-gated luminescence (TGL) bioassays, but their poor water solubility is a main problem that limits their effective uses. In this work we propose a simple and general strategy to enhance the water solubility of luminescent β-diketonate-europium(III) complexes that permits facile synthesis and purification. By introducing the fluorinated carboxylic acid group into the structures of β-diketone ligands, two highly water-soluble and luminescent Eu complexes, PBBHD-Eu and CPBBHD-Eu, were designed and synthesized.

Observation of the validity of the upper lip bite test in predicting difficult intubation.

The upper lip bite test (ULBT) is considered an effective method for predicting difficult airways, but data on the ULBT for predicting difficult tracheal intubation are lacking. This study aimed to examine the clinical utility of the ULBT in predicting difficult endotracheal intubation. We conducted an observational case-cohort study of adult patients undergoing elective surgery and requiring endotracheal intubation for general anesthesia.

FRET Luminescent Probe for the Ratiometric Imaging of Peroxynitrite in Rat Brain Models of Epilepsy-Based on Organic Dye-Conjugated Iridium(III) Complex.

Epilepsy is a chronic neurological disorder characterized by recurrent seizures globally, imposing a substantial burden on patients and their families. The pathological role of peroxynitrite (ONOO), which can trigger oxidative stress, inflammation, and neuronal hyperexcitability, is critical in epilepsy. However, the development of reliable, in situ, and real-time optical imaging tools to detect ONOO in the brain encounters some challenges related to the depth of tissue penetration, background interference, optical bleaching, and spectral overlapping.

Development and validation of a screening method for difficult tracheal intubation based on geometric simulation and computer technology.

Background: The anatomical characteristics of difficult airways can be analysed geometrically. This study aims to develop and validate a geometry-assisted difficult airway screening method (GADAS method) for difficult tracheal intubation.

Methods: In the GADAS method, a geometric simulated model was established based on computer graphics.

Cerebral Small Vessel Disease Is Associated with Motor, Cognitive, and Emotional Dysfunction in Multiple System Atrophy.

Background: Cerebral small vessel disease (CSVD) has not been systematically studied in patients with multiple system atrophy (MSA).

Objective: We sought to explore whether MSA patients suffer from a heavier CSVD burden relative to healthy individuals and whether CSVD has a relationship with motor, cognitive, and emotional dysfunction in patients with MSA.

Methods: This study consecutively recruited 190 MSA patients and 190 matched healthy controls whose overall CSVD burden and single CSVD imaging markers (including white matter hyperintensity (WMH), microbleeds, lacunes, and enlarged perivascular spaces (EPVS)) were measured.

On Bicon-Numbers With Their Basic Properties and Applications in Quantum Systems.

Motivated by the fact that there exists the operation of conjugation in quantum systems, the concept of bicon-numbers is proposed in this article. The bicon-numbers are defined by introducing two symbolic parameters into the set of complex numbers. The basic functions of these two symbolic parameters are specified by an axiom which abstracts the operation of complex conjugation.

Efficacy and Tolerability of Insulin Degludec Versus Other Long-acting Basal Insulin Analogues in the Treatment of Type 1 and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis.

Purpose: The goal of this study was to compare the efficacy and tolerability of insulin degludec with those of other long-acting insulin analogues (insulin glargine and insulin detemir) in patients with type 1 or 2 diabetes mellitus (T1D or T2D).

Methods: Those randomized controlled trials comparing insulin degludec with other long-acting insulin analogues in the treatment of patients with T1D or T2D published on or before August 21, 2022, were retrieved from PubMed, Web of Science, the Cochrane Library, and EMBASE. The efficacy end points were the changes from baseline in hemoglobin A and fasting plasma glucose (FPG).

How does authentic leadership promote taking charge: The mediating effect of team social capital and the moderating effect of absorptive capacity.

Authentic leaders are consistent with the expectations of Chinese traditional cultural values for leaders. The purpose of this study is to take team internal social capital (TISC) as the mediating variable and individual absorptive capacity as the moderating variable to explore the relationship between authentic leadership and taking charge. We collected 337 questionnaires from China and used linear regression to explore the influencing mechanisms and boundary conditions.

Coupling coordination development of energy-economy-carbon emissions in China under the background of "double carbon".

Based on the panel data of 30 provinces in China from 2010 to 2019, this paper measured the coupling coordination development of energy-economy-carbon emissions and investigated its regional differences and spatial convergence. The research methods in this paper include entropy weight technique method for order preference by similarity to an ideal solution, coupling coordination degree model, Dagum Gini coefficient and decomposition method, Moran's I index, σ convergence model and β convergence model. The study found that the coupling coordination degree of energy-economy-carbon emissions in China has been continuously improved and has obvious regional and stage characteristics, but it is still on the verge of imminent disorder; the overall difference in the coupling coordination degree of energy-economy-carbon emissions shows a decreasing and then increasing trend, the main source of which is inter-regional differences; the coupling coordination degree of energy-economy-carbon emissions has a positive spatial correlation; except for the Southern Coastal Economic Zone and the Middle Yangtze River Economic Zone, there is no significant σ-convergence and β-convergence in the coupling coordination degree of energy-economy-carbon emissions system in other economic zones; the coupling coordination degree of energy-economy-carbon emissions changes fastest in the Middle Yangtze River Economic Zone.

A novel nomogram for predicting survival of patients with poorly differentiated gastric adenocarcinoma.

Background: Poorly differentiated gastric adenocarcinoma (PDGA) is a common adenocarcinoma with less glandular structure in gastric cancer. To date, the factors affecting its prognosis remain unclear. In this study, we establish a novel prognostic nomogram for PDGA.

Association of Timing of Biliary Drainage with Clinical Outcomes in Severe Acute Cholangitis: A Retrospective Cohort Study.

Purpose: The guidelines recommend urgent biliary drainage (BD) for severe acute cholangitis, without a clear definition of "urgent". To explore the optimal time, we identified the impact of timing of BD on clinical outcomes in severe acute cholangitis.

Patients And Methods: A retrospective study of patients with severe acute cholangitis was conducted based on the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC-III) database.

Multifunctional organosilicon compound contributes to stable operation of high-voltage lithium metal batteries.

With the increasing demand for high-energy-density energy storage devices, lithium metal batteries have rekindled the interest of researchers due to ultra-high specific capacity. However, the extremely unstable interfaces between the electrolyte and electrodes limit its application seriously. Herein, we introduce an organosilicon compound, 1,3-Divinyltetramethyldisiloxane (DTMDS), as multifunctional electrolyte additive to enhance the performance of LiNiMnO/Li batteries.

A nomogram combining PPARγ expression profiles and clinical factors predicts survival in patients with hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most common primary liver cancer with poor prognosis. Peroxisome proliferator-activated receptor γ (PPARγ) is involved in the development of various tumor types. However, its role in hepatocellular carcinoma (HCC) remains unclear.

Diterpenoid Alkaloid Profiling to Distinguish between the Official Traditional Chinese Medicine (TCM) Fuzi and Adulterant Species Using LC-qToF-MS with Chemometrics.

The lateral roots of , known in Chinese as fuzi, are officially recognized as a materia medica in the and used culinarily to prepare herbal soups. A strategy combining UPLC-qToF-MS analysis of and its intraspecies and interspecies chemometrics study was developed to examine the distribution of marker metabolites. Four diterpenoid alkaloids were recognized to be important markers in fuzi, and another 15 markers were identified to differentiate from adulterant species.

Disability assessment in stroke: Relationship among the pictorial-based Longshi Scale, the Barthel Index, and the modified Rankin Scale.

Objective: To explore the correlations among the Longshi Scale, the Barthel Index, and the modified Rankin Scale and the differentiate ability of the Longshi Scale and the modified Rankin Scale to Barthel Index scores.

Design: Prospective study.

Setting: The inpatient rehabilitation units of three teaching hospitals in China.

Complete plastid genome sequence of (Asteraceae), an endemic traditional Chinese herbal medicine.

is an important traditional Chinese herb endemic to China for cardiovascular and cerebral vessel diseases. Here, the complete plastid genome of was sequenced using Illumina sequencing technology. The complete chloroplast genome size is 152,183 bp, including a large single-copy region of 84,705 bp, a small single-copy region of 18,112 bp and a pair of inverted repeat regions of 24,683 bp.

Research on two-dimensional external magnetic drive method of maglev ball based on force imbalance.

In this paper, an external magnetic driving method of a maglev ball based on force imbalance is first proposed to meet the requirement that the maglev ball is moved linearly in the axis direction of the electromagnetic actuator in the non-liquid environment. This method is expected to be better applied in the fields of industrial and medical miniature curved tube. The maglev ball is a magnetic levitated object.

Fluorophosphorus derivative forms a beneficial film on both electrodes of high voltage lithium-ion batteries.

Layered lithium-rich oxides, as a series of highly promising cathode material for lithium-ion batteries, attract extensive attention due to their high specific capacity and high working potential (4.6 V vs Li/Li). However, the poor interface stability of the cathode and electrolyte seriously restricts their practical application.

Impact of periventricular hyperintensities and cystatin C on different cognitive domains in the population of non-demented elderly Chinese.

Objectives: To investigate the impact of periventricular hyperintensities and serum cystatin C on mild cognitive impairment to provide a basis for the investigation of the pathogenesis.

Method: 286 patients enrolled the study and underwent an examination in Shanghai Fifth People's Hospital from June 2017 to June 2018. The participants' cognitive function was evaluated by different cognitive domains using of mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA), auditory verbal learning test, Huashan version (AVLT-H), digit span test (DST), symbol digit modalities test (SDMT), trail making test (TMT) and verbal fluency test (VFT).

Insulin Resistance Is a Risk Factor for Overall Cerebral Small Vessel Disease Burden in Old Nondiabetic Healthy Adult Population.

: This study aimed to investigate the association between insulin resistance (IR) and the overall cerebral small vessel disease (CSVD) burden. : We recruited elderly, nondiabetic, healthy subjects prospectively. The overall effect of CSVD on the brain was described by a validated CSVD score.

[Gray mold disease of Paris polyphylla var. yunnanensis and its pathogen identification].

Gray mold disease is one of the most important diseases of planted Paris polyphylla var. yunnanensis, the disease appeared primarily as blossom blights and fruit rots, but also as stem rots, leaf rots.In this study, the pathogenetic fungi was isolated from plant tissue or sclerotia that covering the fruit of diseased P.

Four-dimensional flow-sensitive MRI of the thoracic aorta: 12- versus 32-channel coil arrays.

Purpose: To evaluate the performance of four-dimensional (4D) flow-sensitive MRI in the thoracic aorta using 12- and 32-channel coils and parallel imaging.

Materials And Methods: 4D flow-sensitive MRI was performed in the thoracic aorta of 11 healthy volunteers at 3 Tesla (T) using different coils and parallel imaging (GRAPPA) accelerations (R): (i) 12-channel coil, R = 2; (ii) 12-channel coil, R = 3; (iii) 32-channel coil, R = 3. The quantitative analysis included SNR, residual velocity divergence and length and curvature of traces (streamlines and pathlines) as used for 3D flow visualization.