Characterization of Reclaimed Asphalt Pavement Material Properties for Hot In-Place Recycling.

Asphalt with different aging degrees requires different rejuvenation methods. However, current applications of hot in-place recycling (HIR) for Reclaimed Asphalt Pavement (RAP) do not consider the differences in the aging degree of asphalt binder across different layers of RAP. Additionally, there is limited understanding of the changes in asphalt binder and aggregate properties during the HIR process.

Qingre Huayu Jianpi prescription alleviates the inflammatory transformation of colitis-associated colorectal cancer by inhibiting the IL-17RA/ACT1/NF-κB axis.

Ethnopharmacological Relevance: Inflammation-to-cancer transformation is critical for the progression of ulcerative colitis to colitis-associated colorectal cancer (CAC).

Aim Of The Study: To explore the role and potential mechanisms of Qingre Huayu Jianpi prescription (QHJ) treatment in the development of CAC.

Materials And Methods: Combined network pharmacology and transcriptome analyses were used to investigate QHJ-associated targets and pathways in the context of CAC.

Establishment of an indirect ELISA detection method for porcine reproductive and respiratory syndrome virus NSP4.

The non-structural protein 4 (NSP4) of porcine reproductive and respiratory syndrome virus (PRRSV) is equipped with 3C-like serine protease (3CLSP) activity, influencing crucial aspects such as virus replication, host IFN- suppression, host cell apoptosis induction, and PRRSV detection facilitation. In response to wild or attenuated PRRSV strains, antibodies against non-structural proteins are generated, while inactivated vaccines fail to elicit such responses. Employing the Enzyme-Linked Immunosorbent Assay (ELISA) method targeting non-structural proteins helps discern the immune effects of inactivated versus wild or attenuated vaccine strains.

Overcoming Interfacial Hydrogen Site-Blocking during Alkaline Formate Oxidation: Insights from Lattice-Compressed PdZr/C Catalysts.

Improving the electrocatalytic conversion of formate in alkaline solutions is crucial for the commercial application of formate fuel cells. However, palladium-based catalysts used for formate oxidation reactions (FOR) face challenges due to the strong adsorption of hydrogen intermediates, resulting in lower catalytic efficiency in alkaline environments. Herein, we prepared a PdZr/C catalyst aimed at employing a doping-induced strain strategy to reduce the hydrogen binding energy of palladium and release more active sites for the oxidation of formate.

Mesenchymal stem cell exosome therapy: current research status in the treatment of neurodegenerative diseases and the possibility of reversing normal brain aging.

With the exacerbation of the aging population trend, a series of neurodegenerative diseases caused by brain aging have become increasingly common, significantly impacting the daily lives of the elderly and imposing heavier burdens on nations and societies. Brain aging is a complex process involving multiple mechanisms, including oxidative stress, apoptosis of damaged neuronal cells, chronic inflammation, and mitochondrial dysfunction, and research into new therapeutic strategies to delay brain aging has gradually become a research focus in recent years. Mesenchymal stem cells (MSCs) have been widely used in cell therapy due to their functions such as antioxidative stress, anti-inflammation, and tissue regeneration.

Prognostic and predictive effects of new steatotic liver disease nomenclatures: a large population-based study.

We aimed to compare the association of metabolic dysfunction-associated fatty liver disease (MAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), metabolic dysfunction and ALD (MetALD), and MASLD with viral hepatitis (MASLD-Viral) with risks of cirrhosis, liver cancer, and mortality. The data of 464,556 adults from the UK Biobank (UKB), 13,526 adults from the National Health and Nutrition Examination Survey (NHANES), and 2554 adults from BeijngFH Health Cohort Study (FHCS) were included. Adjusted hazard ratios (aHR) and odds ratios were calculated using Cox and Logistic regression models, respectively.

Research Progress on the GP3 Protein of Porcine Reproductive and Respiratory Syndrome Virus.

Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious immunosuppressive disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV) that is characterized by a highly variable gene sequence and a high rate of recombination, thereby contributing to difficulties in the clinical prevention and control of this virus. Glycosylated protein 3 (GP3) is the most glycosylated protein in PRRSV, and is closely associated with the composition of PRRSV virus particles, infection, and immune evasion. This review summarizes the structural features, genetic evolutionary patterns, glycosylation of GP3 and its interactions with other PRRSV and host proteins, associations with PRRSV infection and virulence, and immunomodulatory roles.

Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures.

Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging-related diseases. It has long been speculated that "rejuvenation molecules" exist in their blood to promote extended lifespan. We unexpectedly discovered that longevity individuals exhibit erythrocyte oxygen release function similar to young individuals, whereas most elderly show reduced oxygen release capacity.

The metal-support interactions of Cr(OH) enhance the performance of supported Au-based benzyl alcohol electrooxidation catalysts.

An Au-based heterojunction electrocatalyst supported on Cr(OH) was synthesized by a liquid-phase method. The metal-support interactions between Au and Cr(OH) play a key role in modulating the microstructure and charge distribution of the Au-based active centers. This synergy significantly enhances the catalytic activity and stability for the electrooxidation of benzyl alcohol.

Effect of lignin carbon material on phosphorus solubilisation performance of Bacillus megaterium.

Secondary salinisation significantly compromises soil quality because of the over-application of chemical fertilisers. The combined application of biochar and microorganisms enhanced soil physicochemical properties and improved soil remediation efficiency. However, different types of biochar had varying effects on microbial growth and reproduction.

The Sericini (Coleoptera: Scarabaeidae: Sericinae) from the Nanling Mountains, China.

In this paper we update the knowledge on the species of Sericini occurring in the Nanling Mountains, China. This includes new records of 19 known species. Furthermore, six new species are described: Maladera paradaanensis Liu, Ahrens, Li & Yang, new species, M.

Spin-Electrochemistry of Transition Metal Oxides for Energy Storage: Concepts, Advances and Perspectives.

Developing high-capacity and cyclically stable transition metal (TM)-based electrode materials for energy storage devices, such as aqueous ion energy storage systems, is crucial for addressing the growing issue of energy scarcity. The spin state, or spin configuration of the d-electrons, plays a vital role in the electrochemical energy storage performance of these materials. However, there has been a lack of systematic descriptions regarding the role of spin configurations in electrochemical energy storage to date.

Dung beetle optimization algorithm-based hybrid deep learning model for ultra-short-term PV power prediction.

A hybrid model combining self-attention temporal convolutional networks (SATCN) with bidirectional long short-term memory (BiLSTM) networks was developed to improve the accuracy of ultra-short-term photovoltaic (PV) power prediction. The self-attention mechanism and SATCN were used to extract temporal and correlation features, which were then linked to BiLSTM networks. The model's hyperparameters were optimized using the dung beetle optimization algorithm.

Identifying and ranking causal association between gut microbiota and neuroticism.

Background: Recent studies had explored that gut microbiota was associated with personality traits through the gut-brain axis. Nevertheless, the fundamental causality remained obscure.

Methods: Mendelian randomization (MR) was used to investigate the causal relationship between gut microbiota, metabolites and neuroticism-related traits.

Broadband CaMgZrGeO:Cr garnet phosphor for high-performance NIR pc-LED application.

The near-infrared (NIR) phosphor-converted light-emitting diode (pc-LED) is heavily reliant upon the performance of NIR phosphors. However, the current NIR pc-LEDs suffer from low photoelectric efficiency and insufficient near-infrared output power. In this study, Cr-doped CaMgZrGeO phosphors leading to high-performance NIR pc-LEDs were developed for the first time.

Modeling and prediction of set‑up errors in breast cancer image‑guided radiotherapy using the Gaussian mixture model.

The aim of the present study was to develop a prediction model for set-up error distribution in breast cancer image-guided radiotherapy (IGRT) using a Gaussian mixture model (GMM). To achieve this, the image-guided set-up errors data of 80 patients with breast cancer were selected, and the GMM was used to develop the set-up errors distribution prediction model. The predicted error center points, covariance and probability were calculated and compared with the planning target volume (PTV) margin formula.

Supernormal Temperature Sensing Performance Realized through the Blue Emitting Level of Er along with Detection Ability in Deep Tissues.

Fluorescence intensity ratio (FIR)-type optical thermometers based on thermally coupled energy levels (TCLs) of rare earth ions are suitable candidates for noncontact temperature detection in living organisms, microelectronics apparatus, and so forth. Therefore, the improvement of the thermometric sensitivity of TCL-based thermometers has become a research hotspot in recent years. Herein, ultrahigh sensitivity and outstanding resolution for temperature sensing have been realized in YNbO: Yb/Er.

Mn─O Covalency as a Lever for Na⁺ Intercalation Kinetics: The Role of Oxygen Edge-Sharing Co Octahedral Sites in MnO₂.

The strategic enhancement of manganese-oxygen (Mn─O) covalency is a promising approach to improve the intercalation kinetics of sodium ions (Na⁺) in manganese dioxide (MnO). In this study, an augmenting Mn─O covalency in MnO by strategically incorporating cobalt at oxygen edge-sharing Co octahedral sites is focused on. Both experimental results and density functional theory (DFT) calculations reveal an increased electron polarization from oxygen to manganese, surpassing that directed toward cobalt, thereby facilitating enhanced electron transfer and strengthening covalency.

Quantum Spin Exchange Interactions Trigger O p Band Broadening for Enhanced Aqueous Zinc-Ion Battery Performance.

The pressing demand for large-scale energy storage solutions has propelled the development of advanced battery technologies, among which zinc-ion batteries (ZIBs) are prominent due to their resource abundance, high capacity, and safety in aqueous environments. However, the use of manganese oxide cathodes in ZIBs is challenged by their poor electrical conductivity and structural stability, stemming from the intrinsic properties of MnO and the destabilizing effects of ion intercalation. To overcome these limitations, our research delves into atomic-level engineering, emphasizing quantum spin exchange interactions (QSEI).

Inducing weak and negative Jahn-Teller distortions to alleviate structural deformations for stable sodium storage.

In the quest for efficient supercapacitor materials, manganese-based layered oxide cathodes stand out for their cost-effectiveness and high theoretical capacity. However, their progress is hindered by the Jahn-Teller (J-T) distortion due to the unavoidable Mn to Mn reduction during ion storage processes. Our study addresses this challenge by stabilizing the KMnO cathode through strategic Mg substitution.

Umbilical cord mesenchymal stem cells in ulcerative colitis treatment: efficacy and possible mechanisms.

Background: Mesenchymal stem cells (MSCs) possess powerful immunomodulatory ability. This study aimed to assess the efficacy and safety of human umbilical cord-derived mesenchymal stem cells (UMSCs) in patients with ulcerative colitis (UC) and to explore the potential mechanisms.

Methods: This prospective, self-controlled clinical study was conducted at Henan Provincial People's Hospital.

Diagnostic value of galectin-3, fractalkine, IL-6, miR-21 and cardiac troponin I in human ischemic cardiomyopathy.

Objective: The primary objective of this study was to assess the diagnostic potential of galectin-3 (Gal-3), fractalkine (FKN), interleukin (IL)-6, microRNA(miR)-21, and cardiac troponin I (cTnI) in patients with ischemic cardiomyopathy (ICM).

Method: A total of 78 ICM patients (Case group) and 80 healthy volunteers (Control group) admitted to our hospital for treatment or physical examination from Aug. 2018 to Feb.