A review: Integration of NIRS and chemometric methods for tea quality control-principles, spectral preprocessing methods, machine learning algorithms, research progress, and future directions.

With the steady rise in tea production, the need for effective tea quality monitoring has become increasingly pressing. Traditional sensory evaluation and wet chemical detection methods are insufficient for real-time tea quality monitoring. As an emerging technology, near infrared spectroscopy (NIRS) offers numerous advantages, such as preserving sample integrity, generating objective results, and enabling rapid, straightforward assessments.

Molecular and Proteomic Analyses of Effects of Cadmium Exposure on the Silk Glands of .

Cadmium (Cd) is a pervasive heavy metal pollutant released into the environment through industrial activities such as mining, smelting, and agricultural runoff. This study aimed to investigate the molecular and metabolic impacts of Cd exposure on the silk glands of , a species renowned for producing silk with exceptional mechanical properties. Cd accumulation in spider bodies and silk glands was significantly higher in the low- and high-Cd groups compared to controls, with a dose- and time-dependent increase.

Spatially Isomeric Fulleropyrrolidines Enable Controlled Stacking of Perovskite Colloids for High-Performance Tin-Based Perovskite Solar Cells.

The advancement of tin-based perovskite solar cells (TPSCs) has been severely hindered by the poor controllability of perovskite crystal growth and the energy level mismatch between the perovskite and fullerene-based electron transport layer (ETL). Here, we synthesized three cis-configured pyridyl-substituted fulleropyrrolidines (PPF), specifically 2-pyridyl (PPF2), 3-pyridyl (PPF3), and 4-pyridyl (PPF4), and utilized them as precursor additives to regulate the crystallization kinetics during film formation. The spatial distance between the two pyridine groups in PPF2, PPF3, and PPF4 increases sequentially, enabling PPF4 to interact with more perovskite colloidal particles.

Consolidation immunotherapy following concurrent chemoradiotherapy in a patient with sinonasal NUT carcinoma: a case report.

Background: Nuclear protein in testis (NUT) cancers, also known as midline cancers, tends to occur in organs near the midline, such as the nasal sinuses and mediastinum. NUT carcinoma is very rare and has a poor prognosis.

Case Description: We report the case of a 44-year-old female patient with sinonasal NUT carcinoma who presented with a soft tissue mass in the left frontal sinus, ethmoid sinus, and left nasal cavity on computed tomography; the tumor was poorly demarcated from the left rectus medialis.

Application of deep reinforcement learning in electricity demand response market: Demand response decision-making of load aggregator.

With the large-scale integration of renewable energy generation, developing the potential of demand response is becoming more and more significant. However, the number of consumers is huge, the electricity consumption behaviors are various and the information of consumers is incomplete, thus there are great difficulties in modeling and processing demand response by the conventional mathematical methods. Therefore, how to accurately predict the response behaviors of consumers and select the appropriate consumers for demand response is worthy of in-depth discussion.

Super-resolution reconstruction for early cervical cancer magnetic resonance imaging based on deep learning.

This study aims to develop a super-resolution (SR) algorithm tailored specifically for enhancing the image quality and resolution of early cervical cancer (CC) magnetic resonance imaging (MRI) images. The proposed method is subjected to both qualitative and quantitative analyses, thoroughly investigating its performance across various upscaling factors and assessing its impact on medical image segmentation tasks. The innovative SR algorithm employed for reconstructing early CC MRI images integrates complex architectures and deep convolutional kernels.

Insect-transmitted plant virus balances its vertical transmission through regulating Rab1-mediated receptor localization.

Rice stripe virus (RSV) establishes infection in the ovaries of its vector insect, Laodelphax striatellus. We demonstrate that RSV infection delays ovarian maturation by inhibiting membrane localization of the vitellogenin receptor (VgR), thereby reducing the vitellogenin (Vg) accumulation essential for egg development. We identify the host protein L.

Benzimidazole-based structure optimization to discover novel anti-gastric cancer agents targeting ROS/MAPK pathway.

Given the malignancy of gastric cancer, developing highly effective and low-toxic targeted drugs is essential to prolong patient survival and improve patient outcomes. In this study, we conducted structural optimizations based on the benzimidazole scaffold. Notably, compound 8 f presented the most potent antiproliferative activity in MGC803 cells and induced cell cycle arrest at the G0/G1 phase.

Experiment and analysis of physical, mechanical, and viscoelastic properties of the roots and stalks of green leafy vegetables.

Green leafy vegetables are an essential component of Chinese leafy vegetables. Due to their crisp stems and tender leaves, orderly harvester generally causes significant mechanical clamping damage. The physical and mechanical properties of green leafy vegetables are one of the important basis to design the orderly harvester.

Antitumor activity of dictamnine against colorectal cancer through induction of ferroptosis and inhibition of M2 macrophage polarization via the MAPK signaling.

Colorectal cancer (CRC) is an aggressive cancer type globally. Surgery and chemotherapy are often ineffective at curing CRC. Dictamnine is a natural product derived from Dictamnus dasycarpus Turcz.

Super-resolution algorithm for the characterization of sweat glands in fingerprint OCT images.

Optical coherence tomography (OCT) is a noninvasive optical imaging technique that can be used to produce three-dimensional images of fingerprints. However, the low quality and poor resolution of the regions of interest (ROIs) in OCT images make it challenging to segment small tissues accurately. To address this issue, a super-resolution (SR) network called ESRNet has been developed to enhance the quality of OCT images, facilitating their applications in research.

A computer-aided determining method for the myometrial infiltration depth of early endometrial cancer on MRI images.

To classify early endometrial cancer (EC) on sagittal T2-weighted images (T2WI) by determining the depth of myometrial infiltration (MI) using a computer-aided diagnosis (CAD) method based on a multi-stage deep learning (DL) model. This study retrospectively investigated 154 patients with pathologically proven early EC at the institution between January 1, 2018, and December 31, 2020. Of these patients, 75 were in the International Federation of Gynecology and Obstetrics (FIGO) stage IA and 79 were in FIGO stage IB.

Design and experiments with a single spiral fixed depth ditching and fertilizing machine.

Aiming at the problems of low fertilization efficiency, mainly the process operation and inconsistent fertilization depth of domestic tea garden fertilizer machines, a single-spiral fixed depth ditching and fertilizing machine is appropriately designed. This machine is capable of performing the integrated operation of ditching, fertilization, and covering soil at the same time through the operation mode of single-spiral ditching and fertilization. The theoretical analysis and design of the structure of the main components are properly carried out.

Carbenoxolone disodium suppresses the migration of gastric cancer by targeting HDAC6.

Because of the severe morbidity and mortality of gastric cancer, discovering new candidate drugs has been an urgent issue. The close association between histone deacetylase 6 (HDAC6) and gastric cancer makes the development of HDAC6-targeted anti-gastric cancer drugs a viable idea. Carbenoxolone disodium was identified as a novel HDAC6 inhibitor.

Design and experiments of an automatic depth-adjusting double screw trencher and fertiliserning.

In response to the problems of low fertilizer application efficiency, poor operation quality, and uneven application of fertilizer by domestic tea garden trenching and fertilizing machines, an automatic depth-adjusting double screw trenching and fertilizing machine was designed. The machine uses a double spiral furrowing and fertilizer application method, which can complete the integrated operation of furrowing, fertilizer application, and mulching at one time. The key components of the machine such as the screw-type fertilizer discharger, trenching, and fertilizer application mechanism are designed using theoretical analysis, and the trenching depth is automatically adjusted through the hydraulic control system to maintain a consistent depth.

Silicon enhances plant resistance to wilt by promoting antioxidant potential and photosynthetic capacity in cucumber ( L.).

wilt, caused by f. sp. (Fo), is a severe soil-borne disease affecting cucumber production worldwide, particularly under monocropping in greenhouses.

CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation.

Background: Chemokine CXC motif receptor 7 (CXCR7) is an atypical G protein-coupled receptor (GPCR) that signals in a biased fashion. CXCL12/CXCR7 biased signal has been reported to play crucial roles in multiple stages of colorectal cancer (CRC). However, the mechanism of CXCL12/CXCR7 biased signal in promoting CRC progression and metastasis remains obscure.

Consideration of high-quality development strategies for soil and water conservation on the loess plateau.

The construction of check dams is an important measure to prevent soil erosion on the Loess Plateau and reduce the amount of sediment entering the Yellow River. Based on an analysis of the current situation of soil and water conservation on the Loess Plateau and the three major problems faced by the traditional homogeneous soil check dam construction, the study of anti-scouring materials, hydrological calculation methods, dam design and construction technology and soil and water conservation monitoring are carried out in this paper. The results showed that the current soil and water conservation measures on the Loess Plateau have achieved remarkable outcomes.

GrpE is involved in mitochondrial function and is an effective target for RNAi-mediated pest and arbovirus control.

Laodelphax striatellus is a sap-feeding pest and the main insect vector of rice stripe virus (RSV). There is an urgent need to identify molecular targets to control this insect pest and plant arboviruses. In this study, we identified a L.

Identification and comparative expression analysis of odorant-binding proteins in the reproductive system and antennae of Athetis dissimilis.

Odorant-binding proteins (OBPs) are prevalent in the antennal transcriptomes of different orders of insects. Studies on OBPs have focused on their role in the insect chemosensory system, but knowledge of their functions in the insect testis is limited. We sequenced the transcriptomes of the Athetis dissimilis reproductive organs and analyzed the expression of AdisOBP genes in different tissues.

Monobenzone, a Novel and Potent KDM1A Inhibitor, Suppresses Migration of Gastric Cancer Cells.

Lysine-specific demethylase1 (KDM1A) is generally highly expressed in various cancer tissues, and promotes the initiation and development of cancers via diverse cellular signaling pathways. Therefore, KDM1A is a promising drug target in many cancers, and it is crucial to find effective KDM1A inhibitors, while none of them has entered into market. With the help of compound library, monobenzone, a local depigmentor using as a treating over-pigmentation in clinic, was characterized as an effective KDM1A inhibitor (IC = 0.

Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis.

Aims: Exosomal transfer of miRNAs affects recipient cell proliferation and chemoresistance. Here, we aimed to investigate the role of exosomal miRNAs in controlling cisplatin resistance in non-small cell lung carcinoma (NSCLC).

Main Methods: Paired tumor and normal tissue-derived exosomes were collected from NSCLC patients with low or high responsiveness to cisplatin treatment.

Capsaicin: A "hot" KDM1A/LSD1 inhibitor from peppers.

Capsaicinoids are plant secondary metabolites, and capsaicin is the main principal that responsible to the pungency of chili peppers, with widely application as food additive. In our study, capsaicin was characterized as lysine specific demethylase 1A (KDM1A/LSD1) inhibitor with IC of 0.6 ± 0.

Comparative Proteomic Analysis of Two Species Leaves Under NaCl Stress.

Background: Salinity is a major environmental limiting factor, which affect agricultural production. The two seedlings ( and ) with high economic importance, could not adapt well to higher soil salinity and little is known about their proteomic mechanisms.

Objectives: The mechanisms responsible for the effects of salinity on the two species leaves were examined by means of proteomic analysis.