Donkey Milk Supplementation Alleviates Renal Fibrosis of Chronic Kidney Disease by Enhancing Anti-inflammatory Ability.

Donkey milk, rich in essential nutrients, not only can meet the nutritional needs of patients with chronic kidney disease (CKD) accodding to the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guideline for Nutrition in CKD, but also has strong anti-inflammatory ability. Inflammation is the main driving force of renal fibrosis, directly determining the renal function of CKD. However, the impact of donkey milk on CKD and the underlying mechanism remains unclear.

Revealing the dynamic changes of metabolites and molecular mechanisms of chlorogenic acid accumulation during the leaf development of based on multi-omic analyses.

, a medicinal plant, is utilized for Quezui Tea production from its leaf buds and young leaves. Despite prior research on revealing several medicinal compounds, the comprehensive variations in metabolites during its growth and development, along with the molecular mechanisms underlying high chlorogenic acid (CGA) yield, remain unclear. Through a joint analysis of transcriptomics and proteomics, our study first identified 15 key structural genes and 3 transcription factors influencing CGA biosynthesis in , offering new evidence to understand its regulatory network.

Effects of dietary factors on hyperuricaemia and gout: a systematic review and meta-analysis of observational studies.

This study aimed to gather the best evidence on the relationship between dietary factors and hyperuricaemia and gout. We searched databases including PubMed, Embase, Cochrane, and Web of Science from database creation to July 2023. Meta-analysis showed that consumption of alcohol (OR: 1.

polysaccharides regulate the gut microbiota to modulate metabolites in high-fat diet-induced obese rats.

Polysaccharides (LBP) can benefit lipid parameters such as total cholesterol, triglyceride, and high-density lipoprotein levels and upregulate the level of , increase the diversity of gut microbiota and reduce metabolic disorders, finally relieving weight gain of obese rats. But it cannot reverse the outcome of obesity. Over 30 differential metabolites and four pathways are altered by LBP.

Multi-omics data reveals the disturbance of glycerophospholipid metabolism and linoleic acid metabolism caused by disordered gut microbiota in PM2.5 gastrointestinal exposed rats.

The relationships between fine particulate matter (PM2.5) exposure and health effects are complex and incompletely understood. Evidence suggests that PM2.