Efficacy and safety of angiogenesis inhibitors combined with poly ADP ribose polymerase inhibitors in the maintenance treatment of advanced ovarian cancer: a meta-analysis.

Introduction: This meta-analysis was performed to evaluate the efficacy and safety of angiogenesis inhibitors (Ais) combined with poly ADP ribose polymerase inhibitors (PARPi) in the maintenance treatment of advanced ovarian cancer (OC).

Materials And Methods: A systematic search was conducted in four databases (Pubmed, Embase, Web of Science, and Cochrane) for articles published from the inception of the databases until January 15, 2024. The focus of the search was on articles investigating the combination of Ais with PARPi in the maintenance treatment of ovarian cancer.

Enhanced CO conversion in dielectric barrier discharge plasma coupled with a heterojunction photocatalyst.

CsPbBr quantum dots were grown on ReS nanosheets to form CsPbBr@ReS heterojunctions using an anti-solvent method. The composition, morphology, spatial distribution, and optical absorption of samples were characterized. CsPbBr@ReS-15 exhibits not only a higher photocatalytic performance than CsPbBr due to the improved optical absorption and Z-scheme charge migration, but also a higher CO conversion ratio (35.

Peptide S4 is an entry inhibitor of SARS-CoV-2 infection.

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant socioeconomic burden, and combating COVID-19 is imperative. Blocking the SARS-CoV-2 RBD-ACE2 interaction is a promising therapeutic approach for viral infections, as SARS-CoV-2 binds to the ACE2 receptors of host cells via the RBD of spike proteins to infiltrate these cells. We used computer-aided drug design technology and cellular experiments to screen for peptide S4 with high affinity and specificity for the human ACE2 receptor through structural analysis of SARS-CoV-2 and ACE2 interactions.

Boosting CO Conversion by Synergy of Lead-Free Perovskite CsSnCl and Plasma with HO.

Although dielectric barrier discharge (DBD) plasma is a promising technique for CO conversion, realizing CO-to-alcohol is still challenging via the use of HO. Herein, for the first time, efficient CO conversion was achieved via the synergism between the CsSnCl photocatalyst and DBD plasma assisted by HO. The CO conversion ratio of plasma photocatalysis was 6.

Safety and efficacy of zanubrutinib in relapsed/refractory marginal zone lymphoma: final analysis of the MAGNOLIA study.

The primary analysis of MAGNOLIA, an open-label, single-arm, multicenter, phase 2 study, demonstrated that the next-generation Bruton tyrosine kinase (BTK) inhibitor zanubrutinib provided a high overall response rate (ORR) in patients with relapsed/refractory marginal zone lymphoma (R/R MZL), with a favorable safety/tolerability profile. Presented here, is the final analysis of MAGNOLIA, performed to characterize the durability of response and longer-term safety and tolerability. Zanubrutinib (160 mg twice daily) was evaluated in 68 patients with R/R MZL who had received at least 1 anti-CD20-directed regimen.

Association of Cerebral Hemodynamics and Cognitive Function in Adult Patients with Moyamoya Disease: A Three-Dimensional Pseudo-Continuous Arterial Spin Labeling Study.

Objective: Cognitive dysfunction is a serious complication of moyamoya disease (MMD) in adults, and reduced cerebral blood flow (CBF) might be the potential cause. We aimed to explore the correlation between cerebral hemodynamics and cognitive function in adults with MMD by using three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL).

Methods: A total of 24 MMD patients with a history of cerebral infarction, 25 asymptomatic MMD patients, and 25 healthy controls were prospectively enrolled in this study.

Novelty All-Inorganic Titanium-Based Halide Perovskite for Highly Efficient Photocatalytic CO Conversion.

Lead halide perovskite materials have great potential for photocatalytic reaction due to their low fabrication cost, unique optical absorption coefficient, and suitable band structures. However, the main problems are the toxicity and instability of the lead halide perovskite materials. Therefore, a facile synthetic method is used to prepare lead-free environmentally friendly Cs TiX (X = Cl, Cl Br , Br) perovskite materials.

Synergistic Functional Nanomedicine Enhances Ferroptosis Therapy for Breast Tumors by a Blocking Defensive Redox System.

The upregulation of dihydroorotate dehydrogenase (DHODH) redox systems inside tumor cells provides a powerful shelter against lipid peroxidation (LPO), impeding ferroptosis-induced antitumor responses. To solve this issue, we report a strategy to block redox systems and enhance ferroptotic cancer cell death based on a layered double hydroxide (LDH) nanoplatform (siR/IONs@LDH) co-loaded with ferroptosis agent iron oxide nanoparticles (IONs) and the DHODH inhibitor (siR). siR/IONs@LDH is able to simultaneously release IONs and siR in a pH-responsive manner, efficiently generate toxic reactive oxygen species (ROS) an Fe-mediated Fenton reaction, and synergistically induce cancer cell death upon the acceleration of LPO accumulation.

Facile Synthesis of Weakly Ferromagnetic Organogadolinium Macrochelates-Based T -Weighted Magnetic Resonance Imaging Contrast Agents.

To surmount the major concerns of commercial small molecule Gd chelates and reported Gd-based contrast agents (GBCAs) for magnetic resonance imaging (MRI), a new concept of organogadolinium macrochelates (OGMCs) constructed from the coordination between Gd and macromolecules is proposed. A library of macromolecules were screened for Gd coordination, and two candidates [i.e.

Modification of Polymeric Carbon Nitride with Au-CeO Hybrids to Improve Photocatalytic Activity for Hydrogen Evolution.

The construction of a multi-component heterostructure for promoting the exciton splitting and charge separation of conjugated polymer semiconductors has attracted increasing attention in view of improving their photocatalytic activity. Here, we integrated Au nanoparticles (NPs) decorated CeO (Au-CeO) with polymeric carbon nitride (PCN) via a modified thermal polymerization method. The combination of the interfacial interaction between PCN and CeO via N-O or C-O bonds, with the interior electronic transmission channel built by the decoration of Au NPs at the interface between CeO and PCN, endows CeAu-CN with excellent efficiency in the transfer and separation of photo-induced carriers, leading to the enhancement of photochemical activity.

CdS Nanocubes Adorned by Graphitic CN Nanoparticles for Hydrogenating Nitroaromatics: A Route of Visible-Light-Induced Heterogeneous Hollow Structural Photocatalysis.

Modulating the transport route of photogenerated carriers on hollow cadmium sulfide without changing its intrinsic structure remains fascinating and challenging. In this work, a series of well-defined heterogeneous hollow structural materials consisting of CdS hollow nanocubes (CdS NCs) and graphitic CN nanoparticles (CN NPs) were strategically designed and fabricated according to an electrostatic interaction approach. It was found that such CN NPs/CdS NCs still retained the hollow structure after CN NP adorning and demonstrated versatile and remarkably boosted photoreduction performance.

Lead-Free CsTeX (X = Cl, Br, and I) Perovskite Microcrystals with High Stability for Efficient Photocatalytic CO Reduction.

In response to calling for a sustainable and carbon-neutral economy, the conversion of CO to useful chemicals using the solar energy is a potential tactic to relieve the global energy dilemma and environmental issues, which has been a hot topic so far. Recently, the lead halide perovskites as novel photocatalysts have attracted researchers' interests. However, they generally encounter poor stability and lead toxicity, restricting their large-scale practical applications.

Cycloacceleration of Reactive Oxygen Species Generation Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for Tumor Ferroptosis Therapy.

Because of the insufficiency of hydrogen peroxide, the relatively low rate of Fenton reaction, and the active glutathione (GSH) peroxidase 4 (GPX4) in tumor cells, it is difficult to achieve a desirable efficacy of ferroptosis therapy (FT) for tumors based on nanomaterials. Inspired by the concept of "cyclotron" in physics, in this study, a new concept of cycloacceleration of reactive oxygen species (ROS) generation in tumor cells to realize high-performance FT of tumors is proposed. Typically, a magnetic resonance imaging (MRI) contrast agent of dotted core-shell Fe O /Gd O hybrid nanoparticles (FGNPs) is prepared based on exceedingly small magnetic iron oxide nanoparticles (ES-MIONs).

Biodegradable and biocompatible exceedingly small magnetic iron oxide nanoparticles for T-weighted magnetic resonance imaging of tumors.

Magnetic resonance imaging (MRI) has been widely using in clinical diagnosis, and contrast agents (CAs) can improve the sensitivity MRI. To overcome the problems of commercial Gd chelates-based T CAs, commercial magnetic iron oxide nanoparticles (MIONs)-based T CAs, and reported exceedingly small MIONs (ES-MIONs)-based T CAs, in this study, a facile co-precipitation method was developed to synthesize biodegradable and biocompatible ES-MIONs with excellent water-dispersibility using poly (aspartic acid) (PASP) as a stabilizer for T-weighted MRI of tumors. After optimization of the synthesis conditions, the final obtained ES-MION9 with 3.

The Geometry of Nonlinear Embeddings in Kernel Discriminant Analysis.

Fisher's linear discriminant analysis is a classical method for classification, yet it is limited to capturing linear features only. Kernel discriminant analysis as an extension is known to successfully alleviate the limitation through a nonlinear feature mapping. We study the geometry of nonlinear embeddings in discriminant analysis with polynomial kernels and Gaussian kernel by identifying the population-level discriminant function that depends on the data distribution and the kernel.

Carbon Dioxide Conversion Synergistically Activated by Dielectric Barrier Discharge Plasma and the CsPbBr@TiO Photocatalyst.

Carbon dioxide utilization activated by the integration of plasma and photocatalyst is a promising approach to achieve the mitigation of the greenhouse effect. In this paper, for the first time, the dielectric barrier discharge (DBD) plasma and halide perovskite photocatalysts were synergistically used to facilitate the carbon dioxide conversion. After introducing the photocatalyst into the plasma reactor, the plasma discharge characteristics were improved by the photocatalyst while the active photons, electrons, and vibrationally excited molecules in plasma also enhanced the photocatalytic activity of the photocatalyst.

A tumor microenvironment dual responsive contrast agent for contrary contrast-magnetic resonance imaging and specific chemotherapy of tumors.

Development of magnetic resonance imaging (MRI) contrast agents (CAs) is still one of the research hotspots due to the inherent limitations of - or -weighted CAs and / dual-mode CAs. To dramatically enhance the MRI contrast between tumors and normal tissues, we propose a new concept of contrary contrast-MRI (CC-MRI), whose specific definition is that CC-MRI CAs present a positive or negative signal at normal tissues, but show contrary signals at diseased tissues. To realize CC-MRI of tumors, we designed and developed a tumor microenvironment (TME) dual responsive CA (, SA-FeGdNP-DOX@mPEG), which is almost not responsive under normal physiological conditions, but highly responsive to the acidic and reductive TME.

Assembling Ultrafine SnO Nanoparticles on MIL-101(Cr) Octahedrons for Efficient Fuel Photocatalytic Denitrification.

Effectively reducing the concentration of nitrogen-containing compounds (NCCs) remains a significant but challenging task in environmental restoration. In this work, a novel step-scheme (S-scheme) SnO@MCr heterojunction was successfully fabricated via a facile hydrothermal method. At this heterojunction, MIL-101(Cr) octahedrons are decorated with highly dispersed SnO quantum dots (QDs, approximate size 3 nm).

MRI characteristics of brain edema in preeclampsia/eclampsia patients with posterior reversible encephalopathy syndrome.

Background: The neuroimaging manifestations of eclampsia and preeclampsia often overlap, mainly presenting as posterior reversible encephalopathy syndrome (PRES). The purpose of this retrospective study was to compare the extent and nature of brain edema in eclampsia and preeclampsia patients with PRES based on MRI characteristics.

Methods: One hundred fifty women diagnosed with preeclampsia-eclampsia and undergoing cranial MRI were enrolled; 24 of these were diagnosed as having eclampsia.

Construction of BiMoO/CdS heterostructures with enhanced visible light photocatalytic activity for fuel denitrification.

In this work, a novel step-scheme (S-scheme) BiMoO/CdS heterojunction (HJ) photocatalyst (PC) was successfully prepared by a two-step solvothermal method for the first time. One-dimensional CdS nanorods were prepared by a simple solvothermal method as a synthesis template. Then, a BiMoO precursor was added to obtain a series of BiMoO/CdS HJ composite catalytic materials with different morphologies.

Effects of leukotriene D nasal challenge on bronchial responsiveness and inflammation in asthmatic patients with allergic rhinitis.

Background: In asthmatic patients with allergic rhinitis (AR), increased cysteinyl leukotrienes (CysLTs) production in the secretion of nasal mucosa has been associated with greater bronchial hyperresponsiveness (BHR) after nasal allergen challenge. However, the role of CysLTs in eliciting BHR after nasal allergen challenge has not been evaluated. The aim of this study is to evaluate the effect of LTD nasal challenge on BHR and inflammation in asthmatic patients with AR.

Nickel and zinc complexes with a monodentate heterocycle and tridentate Schiff base ligands: self-assembly to one- and two-dimensional supramolecular networks via hydrogen bonding.

In the complex (morpholine)[2-hydroxy-N'-(5-nitro-2-oxidobenzylidene)benzohydrazidato]nickel(II), [Ni(C(14)H(9)N(3)O(5))(C(4)H(9)NO)], (I), the Ni(II) center is in a square-planar N(2)O(2) coordination geometry. The complex bis[mu-2-hydroxy-N'-(2-oxidobenzylidene)benzohydrazidato]bis[(morpholine)zinc(II)], [Zn(2)(C(14)H(10)N(2)O(3))(2)(C(4)H(9)NO)(2)], (II), consists of a neutral centrosymmetric dimer with a coplanar Zn(2)(mu(2)-O)(2) core. The two Zn(II) centers are bridged by phenolate O atoms.