Transcriptome Landscape of Cancer-Associated Fibroblasts in Human PDAC.

Cancer-associated fibroblasts (CAFs) play a crucial role in the progression of pancreatic ductal adenocarcinoma (PDAC). Here, integrated single-cell RNA sequencing analysis is utilized to comprehensively map CAFs in the human PDAC tumor microenvironment (TME). Normal fibroblasts (NFs) and nine distinct CAF subtypes are identified including newly identified CAF subtypes, CDCP1FTL CAFs, transitional CAFs (tCAFs), interferon simulated genes (ISG) myofibroblastic CAFs (myCAFs), and proliferative CAFs (pCAFs).

Improved treatment of colorectal liver metastases by early response evaluation and regimen adjustment: a prospective study of clinical functional MR-based modeling.

Objective: The aim of the study was to evaluate the feasibility of functional MR in predicting the clinical response to chemotherapy in patients with colorectal liver metastases (CLM).

Methods: A total of 196 eligible patients were enrolled in the study between August 2016 and January 2023. Functional MR was performed at baseline and after one cycle of chemotherapy.

Condensed tannin from extraction and protection effects on intestinal barrier function in mice.

tannins (CKT) were extracted by response surface methodology and the protection effect of CKT on the jejunal mucosal barrier function of mice was investigated. Firstly, this work presents the extraction, purification and characterization of CKT. The results show that the extraction conditions were as follows: extraction temperature was 52°C, extraction time was 95 min, liquid-solid ratio was 20:1 and acetone volume fraction was 62%.

Association between serum high-sensitivity C-reactive protein levels and osteoarthritis in adults from NHANES 2015 to 2018.

To explore the association between serum high-sensitivity C-reactive protein (HSCRP) levels and osteoarthritis (OA) in adults, providing new evidence for the diagnosis of adult OA. We selected data from the 2015-2018 National Health and Nutrition Examination Survey (NHANES) and conducted a cross-sectional study. Serum HSCRP levels were extracted from laboratory data, and OA patients were identified through questionnaire responses.

Research on Envelope Profile of Lithium Niobate on Insulator Stepped-Mode Spot Size Converter.

To enhance the end-face coupling efficiency of lithium niobate on insulator (LNOI) chips, in conjunction with current device fabrication processes, a stepped spot size converter (SSC) based on a special outer envelope profile has been proposed and investigated. This stepped SSC can reduce the coupling loss between the LNOI waveguide and a normal single-mode optical fiber. First, the output waveguide of a mode converter was proposed and simulated, in which the mode field had the biggest overlapping integral factor with a single-mode fiber (MDF ≈ 9.

Patterns of Co-Occurring Birth Defects in Chinese Infants With Congenital Diaphragmatic Hernia: A National Hospital-Based Surveillance Study.

Background: The landscape of co-occurring birth defects among infants with congenital diaphragmatic hernia (CDH) remains underexplored.

Aims: This study aims to elucidate the complex patterns of co-occurring defects in Chinese population.

Materials And Methods: We analyzed cases from the Chinese Birth Defects Monitoring Network (2007-2019) with CDH that presented along with at least one additional defect but without a syndromic diagnosis.

Impact of nursing interventions on hemodialysis patients using the integrated theory of health behavior change.

This study investigated the impact of nursing interventions based on the Integrated Theory of Health Behavior Change on hemodialysis patients. A retrospective analysis of 713 hemodialysis patients' electronic medical records from June 2020 to November 2023 was conducted. Patients were divided into an experimental group, receiving nursing interventions based on the theory, and a control group, receiving regular nursing care.

Association between the Achievement of Textbook Outcomes in Liver Surgery and Overall Survival in Perihilar Cholangiocarcinoma Patients following Major Hepatectomy: A Multicenter Study.

Introduction: Major hepatectomy is the mainstay of curative-intent resection for perihilar cholangiocarcinoma (pCCA) patients. Textbook outcomes in liver surgery (TOLS) are a new composite parameter for evaluating the short-term outcomes of surgery; however, their association with overall survival (OS) is unknown. Therefore, this study aimed to investigate the association between TOLS and OS in pCCA patients following major hepatectomy.

Nuclear transmembrane protein 199 promotes immune escapes by up-regulating programmed death ligand 1.

The function of transmembrane protein 199 (TMEM199) in cancer development has rarely been studied thus far. We report the nuclear localization of the TMEM199 protein and further analyzed the truncated fractions that mediate its nuclear localization. Cut&Tag assay globally explores the nuclear-located TMEM199 functions and tests its influence on the immune checkpoint PD-L1 and .

Particular Chinese contributions to extracorporeal liver surgery.

Extracorporeal liver surgery (ELS), also known as liver autotransplantation, is a hybrid (cross-fertilized) surgery incorporating the technical knowledge from extreme liver and transplant liver surgeries, and recently became more embraced and popularized among leading centers. ELS could be summarized into three major categories, namely, ex-situ liver resection and autotransplantation (ELRA), ante-situm liver resection and autotransplantation (ALRA) and auxiliary partial liver autotransplantation (APLA). The successful development of ELS during the past 37 years is definitely inseparable from continuous efforts done by Chinese surgeons and researchers.

Enhanced piezoelectric photocatalytic activity of MXene/ZnS/FeO via Three-in-One strategy based on dual Schottky heterojunction, interface electric field, and oxygen vacancy for pollutant degradation and removal.

Synergism of piezoelectricity and photocatalysis is an effective approach for pollutant degradation and removal, and has garnered considerable attention. Nonetheless, great challenges still remain in recombination and slow migration rate of charge carriers. For response, a novel Three-in-One strategy based on MXene/ZnS/FeO (MZF) was developed to enhance the piezoelectric photocatalytic activity via achieving a triple effect: Dual Schottky heterojunction, Interface electric field, and Oxygen vacancy.

Pathophysiology-Directed Engineering of a Combination Nanoanalgesic for Neuropathic Pain.

Neuropathic pain, one of the most refractory pain diseases, remains a formidable medical challenge. There is still an unmet demand for effective and safe therapies to address this condition. Herein, a rat model of nerve injury-induced neuropathic pain is first established to explore its pathophysiological characteristics.

Duraplasty promotes functional recovery by alleviating intraspinal pressure and edema following severe spinal cord compression injury in rabbits: experimental studies.

Background: After acute traumatic spinal cord injury (tSCI), various surgical strategies have been developed to alleviate elevated intraspinal pressure (ISP) and secondary injury.

Purpose: Our study aimed to investigate the impacts of duraplasty and laminectomy on edema progression, perfusion and functional outcomes after severe balloon compression SCI.

Study Design: In vivo animal study.

Combined transcriptome and metabolome analysis revealed the antimicrobial mechanism of Griseorhodin C against Methicillin-resistant Staphylococcus aureus.

The global rise of multidrug-resistant pathogens, particularly Methicillin-resistant Staphylococcus aureus (MRSA), has become a critical public health concern, necessitating the urgent discovery of new antimicrobial agents. Griseorhodin C, a hydroxyquinone compound isolated from Streptomyces, has demonstrated significant inhibitory effects against MRSA. In this study, we employed a comprehensive approach combining transcriptome and metabolome analyses to investigate the underlying antimicrobial mechanism of Griseorhodin C.

Visual consistency between display simulation and real scene observation: a case study for color preference assessment for illuminated scenes.

Display-based simulation has been widely adopted across various research fields, yet the visual consistency between this technique and real scene observation remains inadequately demonstrated. This study aimed to assess the feasibility of quantifying the color rendition performance of white light sources using display simulation. We examined the visual consistency through two psychophysical experiments conducted with the assistance of spectral imaging and color management.

Image quality improvement for a hybrid compressive light field display based on gradient descent with a mixed loss function.

The multi-layer compressive light field (CLF) three-dimensional (3D) display suffers from image artifacts due to layer misalignment. In this paper, we propose to reduce the image artifacts by improving the intensity distribution uniformity of the layer images. To achieve this, a global optimization algorithm based on gradient descent (GD) is proposed.

Long- and short-term outcomes for resectable gallbladder carcinoma patients treated with curative-intent laparoscopic versus open resection: a multicenter propensity score-matched comparative study.

Background: Gallbladder cancer (GBC) was once considered a contraindication for laparoscopic surgery, but it is becoming more common to use laparoscopic surgery for GBC treatment. The aim of this study was to analyze the long- and short-term outcomes of patients with more advanced T-staged GBC treated with curative intent as defined by the National Comprehensive Cancer Network (NCCN) after laparoscopic resection (LR) versus open resection (OR).

Methods: A multicenter database was used to select consecutive GBC patients treated with curative-intent resection as defined by the NCCN between 2016 and 2020.

Temporal trends in the prevalence of major birth defects in China: a nationwide population-based study from 2007 to 2021.

Background: Birth defects constitute a significant public health issue worldwide, yet there is a lack of comprehensive population-based data for the Chinese population.

Methods: We analyzed data from the China National Population-based Birth Defects Surveillance System from 2007 to 2021, we calculated the prevalence rates of selected birth defects, stratified by maternal residence, geographic region, maternal age, and infant sex. The Joinpoint regression model was utilized to assess trends and annual percent changes in prevalence.