Publications by authors named "Zhiyu Chen"

Cancer-associated fibroblasts (CAFs) play a crucial role in the progression of pancreatic ductal adenocarcinoma (PDAC). Here, integrated single-cell RNA sequencing analysis is utilized to comprehensively map CAFs in the human PDAC tumor microenvironment (TME). Normal fibroblasts (NFs) and nine distinct CAF subtypes are identified including newly identified CAF subtypes, CDCP1FTL CAFs, transitional CAFs (tCAFs), interferon simulated genes (ISG) myofibroblastic CAFs (myCAFs), and proliferative CAFs (pCAFs).

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Objective: The aim of the study was to evaluate the feasibility of functional MR in predicting the clinical response to chemotherapy in patients with colorectal liver metastases (CLM).

Methods: A total of 196 eligible patients were enrolled in the study between August 2016 and January 2023. Functional MR was performed at baseline and after one cycle of chemotherapy.

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tannins (CKT) were extracted by response surface methodology and the protection effect of CKT on the jejunal mucosal barrier function of mice was investigated. Firstly, this work presents the extraction, purification and characterization of CKT. The results show that the extraction conditions were as follows: extraction temperature was 52°C, extraction time was 95 min, liquid-solid ratio was 20:1 and acetone volume fraction was 62%.

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To explore the association between serum high-sensitivity C-reactive protein (HSCRP) levels and osteoarthritis (OA) in adults, providing new evidence for the diagnosis of adult OA. We selected data from the 2015-2018 National Health and Nutrition Examination Survey (NHANES) and conducted a cross-sectional study. Serum HSCRP levels were extracted from laboratory data, and OA patients were identified through questionnaire responses.

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To enhance the end-face coupling efficiency of lithium niobate on insulator (LNOI) chips, in conjunction with current device fabrication processes, a stepped spot size converter (SSC) based on a special outer envelope profile has been proposed and investigated. This stepped SSC can reduce the coupling loss between the LNOI waveguide and a normal single-mode optical fiber. First, the output waveguide of a mode converter was proposed and simulated, in which the mode field had the biggest overlapping integral factor with a single-mode fiber (MDF ≈ 9.

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Background: The landscape of co-occurring birth defects among infants with congenital diaphragmatic hernia (CDH) remains underexplored.

Aims: This study aims to elucidate the complex patterns of co-occurring defects in Chinese population.

Materials And Methods: We analyzed cases from the Chinese Birth Defects Monitoring Network (2007-2019) with CDH that presented along with at least one additional defect but without a syndromic diagnosis.

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This study investigated the impact of nursing interventions based on the Integrated Theory of Health Behavior Change on hemodialysis patients. A retrospective analysis of 713 hemodialysis patients' electronic medical records from June 2020 to November 2023 was conducted. Patients were divided into an experimental group, receiving nursing interventions based on the theory, and a control group, receiving regular nursing care.

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Introduction: Major hepatectomy is the mainstay of curative-intent resection for perihilar cholangiocarcinoma (pCCA) patients. Textbook outcomes in liver surgery (TOLS) are a new composite parameter for evaluating the short-term outcomes of surgery; however, their association with overall survival (OS) is unknown. Therefore, this study aimed to investigate the association between TOLS and OS in pCCA patients following major hepatectomy.

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The function of transmembrane protein 199 (TMEM199) in cancer development has rarely been studied thus far. We report the nuclear localization of the TMEM199 protein and further analyzed the truncated fractions that mediate its nuclear localization. Cut&Tag assay globally explores the nuclear-located TMEM199 functions and tests its influence on the immune checkpoint PD-L1 and .

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Extracorporeal liver surgery (ELS), also known as liver autotransplantation, is a hybrid (cross-fertilized) surgery incorporating the technical knowledge from extreme liver and transplant liver surgeries, and recently became more embraced and popularized among leading centers. ELS could be summarized into three major categories, namely, ex-situ liver resection and autotransplantation (ELRA), ante-situm liver resection and autotransplantation (ALRA) and auxiliary partial liver autotransplantation (APLA). The successful development of ELS during the past 37 years is definitely inseparable from continuous efforts done by Chinese surgeons and researchers.

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Synergism of piezoelectricity and photocatalysis is an effective approach for pollutant degradation and removal, and has garnered considerable attention. Nonetheless, great challenges still remain in recombination and slow migration rate of charge carriers. For response, a novel Three-in-One strategy based on MXene/ZnS/FeO (MZF) was developed to enhance the piezoelectric photocatalytic activity via achieving a triple effect: Dual Schottky heterojunction, Interface electric field, and Oxygen vacancy.

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Neuropathic pain, one of the most refractory pain diseases, remains a formidable medical challenge. There is still an unmet demand for effective and safe therapies to address this condition. Herein, a rat model of nerve injury-induced neuropathic pain is first established to explore its pathophysiological characteristics.

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Background: After acute traumatic spinal cord injury (tSCI), various surgical strategies have been developed to alleviate elevated intraspinal pressure (ISP) and secondary injury.

Purpose: Our study aimed to investigate the impacts of duraplasty and laminectomy on edema progression, perfusion and functional outcomes after severe balloon compression SCI.

Study Design: In vivo animal study.

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The global rise of multidrug-resistant pathogens, particularly Methicillin-resistant Staphylococcus aureus (MRSA), has become a critical public health concern, necessitating the urgent discovery of new antimicrobial agents. Griseorhodin C, a hydroxyquinone compound isolated from Streptomyces, has demonstrated significant inhibitory effects against MRSA. In this study, we employed a comprehensive approach combining transcriptome and metabolome analyses to investigate the underlying antimicrobial mechanism of Griseorhodin C.

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Article Synopsis
  • Chronic diabetic wounds face major issues due to persistent inflammation and bacterial infections, making healing difficult.
  • Researchers developed a new type of nanozyme hydrogels called E-bio-HJ, which effectively scavenge reactive oxygen species (ROS) and promote wound healing by enhancing catalase-like activity.
  • The E-bio-HJ/Gel hydrogels improve inflammation, boost immune response, and promote cell migration and tissue regeneration, offering a promising strategy for rapid diabetic wound healing.
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  • A 54-year-old male liver transplant patient initially treated with tacrolimus developed renal dysfunction, prompting a switch to sirolimus for immunosuppression.
  • After starting sirolimus, the patient experienced worsening renal function and later developed rhabdomyolysis, linked to high sirolimus levels in serum and specific kidney damage seen in histopathology.
  • Reducing the sirolimus dosage led to normalization of muscle enzyme levels and improved kidney function, emphasizing the need for careful monitoring of sirolimus concentrations to prevent such serious side effects.
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Display-based simulation has been widely adopted across various research fields, yet the visual consistency between this technique and real scene observation remains inadequately demonstrated. This study aimed to assess the feasibility of quantifying the color rendition performance of white light sources using display simulation. We examined the visual consistency through two psychophysical experiments conducted with the assistance of spectral imaging and color management.

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The multi-layer compressive light field (CLF) three-dimensional (3D) display suffers from image artifacts due to layer misalignment. In this paper, we propose to reduce the image artifacts by improving the intensity distribution uniformity of the layer images. To achieve this, a global optimization algorithm based on gradient descent (GD) is proposed.

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  • The text refers to a correction made to an academic article with the DOI 10.3389/fnins.2021.823550.
  • This indicates that there were errors or updates in the original publication.
  • Corrections of this nature are important for maintaining the accuracy and credibility of scientific research.
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Article Synopsis
  • * A custom bioreactor was developed to create optimal culture conditions by using brief mechanical rotation to foster better aggregate sizes and improve cell viability, achieving a notable 144-fold increase in cell proliferation.
  • * After 14 days, the NK-92MI cells retained their characteristics and displayed increased IFN-γ expression following IL-18 activation, enhancing their ability to target cancer cells effectively, indicating a valuable method for advancing immunocellular therapies.
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Background: Gallbladder cancer (GBC) was once considered a contraindication for laparoscopic surgery, but it is becoming more common to use laparoscopic surgery for GBC treatment. The aim of this study was to analyze the long- and short-term outcomes of patients with more advanced T-staged GBC treated with curative intent as defined by the National Comprehensive Cancer Network (NCCN) after laparoscopic resection (LR) versus open resection (OR).

Methods: A multicenter database was used to select consecutive GBC patients treated with curative-intent resection as defined by the NCCN between 2016 and 2020.

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Background: Birth defects constitute a significant public health issue worldwide, yet there is a lack of comprehensive population-based data for the Chinese population.

Methods: We analyzed data from the China National Population-based Birth Defects Surveillance System from 2007 to 2021, we calculated the prevalence rates of selected birth defects, stratified by maternal residence, geographic region, maternal age, and infant sex. The Joinpoint regression model was utilized to assess trends and annual percent changes in prevalence.

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Article Synopsis
  • * Research involved analyzing liver samples from grafted rats to investigate the role of neutrophil extracellular traps (NETs) in causing bile duct injury through mechanisms like the PIEZO1/SRC pathway.
  • * Increasing hepatic arterial blood flow with Verapamil can suppress NET extravasation, presenting a potential treatment to mitigate biliary complications after liver transplants.
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Article Synopsis
  • This study focused on the prevalence and distribution of carcinoma along the liver margin (LM) in patients with resected perihilar cholangiocarcinoma (pCCA) and aimed to improve examination methods for LM.!
  • The research analyzed 227 pCCA cases, revealing a significantly higher rate of R1 resection (indicating the presence of cancer at the margin) in the group assessed with whole-mount digital large sections compared to those assessed with smaller sections.!
  • Findings indicate that positive LM is a critical factor for poor surgical outcomes and suggest that precise examination within a 20 mm radius of the proximal ductal margin is necessary, particularly for patients with a margin of less than 5 mm, to enhance diagnostic
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