Publications by authors named "Zhiyou Shi"
Article Synopsis
- High-altitude environments can lead to bone density loss, and understanding how this happens is crucial for developing treatments; this study investigated bone changes in young rats exposed to low oxygen conditions and the effects of bloodletting therapy.
- Male juvenile Sprague-Dawley rats were placed in simulated high-altitude conditions for 12 weeks, with some receiving a weekly bloodletting treatment, and various techniques were used to analyze their bone structure.
- Results showed a significant decrease in bone quality due to low oxygen, with changes in specific bone-related proteins, but bloodletting's overall impact on bone structure was minimal despite some regulatory effects on gene expression.
Introduction: Osteoporotic fractures are a leading cause of disability and contribute significantly to medical care costs worldwide. Variations in bone mineral density and the risk of osteoporosis are notably influenced by altitude. This study aims to longitudinally examine individuals with osteoporosis and low bone mass at three different altitudes (low, high and very high) to understand the effects of high-altitude environments on bone density.
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