Post-translational modifications of immune checkpoints: unlocking new potentials in cancer immunotherapy.

Immunotherapy targeting immune checkpoints has gained traction across various cancer types in clinical settings due to its notable advantages. Despite this, the overall response rates among patients remain modest, alongside issues of drug resistance and adverse effects. Hence, there is a pressing need to enhance immune checkpoint blockade (ICB) therapies.

Correction: Chen et al. Transcriptome Analysis of Larvae Exposed to a Semi-Lethal Dose of Vermistatin. 2025, , 31.

In the original publication [...

Combined Effects of Compound Low-Sodium Alternative Salts and Vacuum Tumbling on the Quality, Water Distribution, and Microstructure of Marinated Beef.

This study proposes a compound low-sodium alternative salt (CLSAS) formulation (2.4% sodium chloride, 0.8% K lactate, 0.

Transcriptome Analysis of Larvae Exposed to a Semi-Lethal Dose of Vermistatin.

is a notorious vector transmitting severe diseases such as Zika virus and West Nile virus to humans worldwide. Vermistatin is a type of funicon-like compound and was first isolated from in the 1970s. Vermistatin has shown promising activity against larvae in our previous research.

NAC transcription factor GbNTL9 modifies the accumulation and organization of cellulose microfibrils to enhance cotton fiber strength.

Introduction: Fiber strength is a critical determinant of fiber quality, with stronger fibers being highly preferred in the cotton textile industry. However, the genetic basis and the specific regulatory mechanism underlying the formation of cotton fiber strength remain largely unknown.

Objectives: To explore fiber strength-related genes, QTL mapping, map-based cloning, and gene function verification were conducted in a backcross inbred line BS41 derived from interspecific hybridization between upland cotton and sea-island cotton.

Immune response of chickens with aIBDV infection by high-throughput sequencing in chickens.

Infectious bursal disease (IBD) can result in significant immunosuppression and bursal damage in 3-6 week chickens. To investigate the role of important genes from chicken during IBD virus (IBDV) infection, Jinghong laying hens were used to clarify the pathways of immune response. The transcriptional profiles of cecal tonsil of chickens were performed by high-throughput sequencing at the first day and third day post IBDV infection (dpi) and the transcriptional levels of three immunity-related genes, namely IPMK, TAB3, and ZC3H12A, were confirmed in vitro by qPCR.

Siamese comparative transformer-based network for unsupervised landmark detection.

Landmark detection is a common task that benefits downstream computer vision tasks. Current landmark detection algorithms often train a sophisticated image pose encoder by reconstructing the source image to identify landmarks. Although a well-trained encoder can effectively capture landmark information through image reconstruction, it overlooks the semantic relationships between landmarks.

Impact of Condensed Tannin and Sulfur Dioxide Addition on Acetaldehyde Accumulation and Anthocyanin Profile of L. Cv. Cabernet Sauvignon Wines During Alcoholic Fermentation.

Acetaldehyde is a key carbonyl by-product during red wine alcoholic fermentation; it is reactive and takes part in certain reactions involving anthocyanin. The aim of this study was to investigate the influence of SO and condensed tannin on the acetaldehyde accumulation of () during alcoholic fermentation and the ripple effect on wine anthocyanin. In this study, six sets of Cabernet Sauvignon alcoholic fermentation with two different sulfur levels (HS and LS) were carried out by adding exogenous condensed tannins before fermentation (T0) in the acetaldehyde rise period (TA) of and at the end of fermentation (TE), separately.

Rapid preparation of bioadhesive hydrogels containing catechol moieties at room temperature with reproducible adhesion to wet tissues, antimicrobial, antioxidant capacity for noncompressive hemostasis.

In order to cope with the massive tissue bleeding caused by sudden trauma and the demand for bioengineering materials with adjustable wet adhesion properties, this study formed the first layer of network by adding galactomannan (GG) and collagen (Col) structure, and then use the Fe-urushiol (UH) redox system to activate free radicals to initiate the polymerization of acrylic acid (AA) to quickly form an interpenetrating double network hydrogel. The cis hydroxyl group in GG and the hydroxyl group of UH form dynamic covalent borate ester bonds with borate ions in the borax solution, and use their responsiveness to pH to control the catechol group to achieve controllable adhesion. UH and Fe endowed the hydrogel with excellent antibacterial ability, while adding Col enhanced the mechanical properties of the hydrogel.

Creeping Stem 1 regulates directional auxin transport for lodging resistance in soybean.

Soybean, a staple crop on a global scale, frequently encounters challenges due to lodging under high planting densities, which results in significant yield losses. Despite extensive research, the fundamental genetic mechanisms governing lodging resistance in soybeans remain elusive. In this study, we identify and characterize the Creeping Stem 1 (CS1) gene, which plays a crucial role in conferring lodging resistance in soybeans.

Sequential multiple mediating effect of loneliness and family health on physical frailty and willingness to age at home in older adults: a national survey in China.

Background: With the rapid ageing of the global population, the number of older adults with physical frailty has been gradually increasing, making ageing at home a key strategy for coping with this demographic change. The opinions of older adults regarding their willingness to age at home deserve to be considered respectfully. As a result, this study aimed to investigate willingness to age at home and any associated underlying mechanisms involving physical frailty among older Chinese adults.

TRANSPARENT TESTA 16 collaborates with the MYB-bHLH-WD40 transcriptional complex to produce brown fiber cotton.

Naturally colored cotton (NCC; Gossypium spp.) does not require additional chemical dyeing and is an environmentally friendly textile material with great research potential and applications. Our previous study using linkage and association mapping identified TRANSPARENT TESTA 2 (Gh_TT2) as acting on the proanthocyanin synthesis pathway.

Unraveling the orientation of an enzyme adsorbed onto a metal-organic framework.

Bio-conversion of lignocellulosic biomass to bioethanol fuel is a highly desirable yet challenging objective because of the low catalytic activity and high cost of β-glucosidase (BGL). Recently, ZIF-8, an emerging organic porous material, has been proposed as a promising candidate for enzyme immobilization to improve associated activity and stability. However, the underlying interaction mechanism of binding BGL on the ZIF-8 surface is yet to be clarified.

The pathway of social support in enhancing adolescents' physical fitness: The mediating roles of physical activity and self-efficacy.

Purpose: Utilising Welk's Youth Physical Activity Promotion (YPAP) model as a foundational framework, this study investigates the intricate interplay of social support, physical activity (PA), and self-efficacy in relation to physical fitness within the context of Chinese culture. The primary objective is to identify the nuanced dynamics among social support, self-efficacy, PA, and physical fitness to enhance adolescent well-being and fitness.

Methodology: The study employed a convenience sampling method, engaging 123 adolescents aged 18-21, of which 67 were females (54.

Lignin hydrogel sensor with anti-dehydration, anti-freezing, and reproducible adhesion prepared based on the room-temperature induction of zinc chloride-lignin redox system.

In recent years, flexible sensors constructed mainly from hydrogels have received increasing attention. However, conventional hydrogels need to be prepared by high-temperature or radiation-induced polymerization reactions, which limits their practical applications due to their suboptimal electrical conductivity and weak mechanical properties. In this paper, using sodium lignosulfonate as the raw material, a dynamic catechol-quinone redox system formed by lignin‑zinc ions was constructed to initiate rapid free radical polymerization of acrylamide (AM) monomer at room temperature.

Attention-based stackable graph convolutional network for multi-view learning.

In multi-view learning, graph-based methods like Graph Convolutional Network (GCN) are extensively researched due to effective graph processing capabilities. However, most GCN-based methods often require complex preliminary operations such as sparsification, which may bring additional computation costs and training difficulties. Additionally, as the number of stacking layers increases in most GCN, over-smoothing problem arises, resulting in ineffective utilization of GCN capabilities.

Hydroxyl-Amide Alkaloids from Pepper Roots: Potential Sources of Natural Antioxidants and Tyrosinase Inhibitors.

Pepper ( L.) is a widely used spice plant known for its fruits and roots, which serve as flavor enhancers in culinary applications and hold significant economic value. Despite the popularity of pepper fruits, their roots remain relatively understudied, with limited research conducted on their bioactive components.

IFITM3 reduces infectious bursal disease virus proliferation by regulating interferon expression.

Interferon-inducible transmembrane protein 3 (IFITM3), a member of the interferon-stimulating factor (ISG) family, has various antiviral functions. Infectious bursal disease virus (IBDV) mainly invades the bursa of Fabricius in chickens, causing a reduction in their immunity and resulting in death from secondary infections. Our previous study found that IBDV infection promotes the expression of chicken IFITM3.

[Medium- and long-term effectiveness of hip revision with SL-PLUS MIA stem in patients with Paprosky type - femoral bone defect].

Objective: To investigate the medium- and long-term effectiveness of hip revision with SL-PLUS MIA stem in patients with Paprosky typeⅠ-Ⅲ femoral bone defect.

Methods: Between June 2012 and December 2018, 44 patients with Paprosky typeⅠ-Ⅲ femoral bone defect received hip revision using SL-PLUS MIA stem. There were 28 males and 16 females, with an average age of 57.

Enhanced Interfacial Electron Transfer in Photocatalyst-Natural Enzyme Coupled Artificial Photosynthesis System: Tuning Strategies and Molecular Simulations.

Laccase is capable of catalyzing a vast array of reactions, but its low redox potential limits its potential applications. The use of photocatalytic materials offers a solution to this problem by converting absorbed visible light into electrons to facilitate enzyme catalysis. Herein, MIL-53(Fe) and NH-MIL-53(Fe) serve as both light absorbers and enzyme immobilization carriers, and laccase is employed for solar-driven chemical conversion.