RcSPL1-RcTAF15b regulates the flowering time of rose ().

Rose (), which is an economically valuable floral species worldwide, has three types, namely once-flowering (OF), occasional or re-blooming (OR), and recurrent or continuous flowering (CF). However, the mechanism underlying the effect of the age pathway on the duration of the CF or OF juvenile phase is largely unknown. In this study, we observed that the transcript levels were substantially upregulated during the floral development period in CF and OF plants.

Enhancer methylation dynamics drive core transcriptional regulatory circuitry in pan-cancer.

Accumulating evidence has demonstrated that enhancer methylation has strong and dynamic regulatory effects on gene expression. Some transcription factors (TFs) can auto- and cross-regulate in a feed-forward manner, and cooperate with their enhancers to form core transcriptional regulatory circuitries (CRCs). However, the elaborated regulatory mechanism between enhancer methylation and CRC remains the tip of the iceberg.

Comprehensive characterization genetic regulation and chromatin landscape of enhancer-associated long non-coding RNAs and their implication in human cancer.

Long non-coding RNAs (lncRNAs) that emanate from enhancer regions (defined as enhancer-associated lncRNAs, or elncRNAs) are emerging as critical regulators in disease progression. However, their biological characteristics and clinical relevance have not been fully portrayed. Here, based on the traditional expression quantitative loci (eQTL) and our optimized residual eQTL method, we comprehensively described the genetic effect on elncRNA expression in more than 300 lymphoblastoid cell lines.

Characterization of the emerging multidrug-resistant Salmonella enterica serotype Kentucky ST314 in China.

Salmonella enterica serotype Kentucky (S. Kentucky) is an important Salmonella serotype with multiple sequence types (ST) with a worldwide incidence. We identified 8 STs from 180 strains of S.

Fourth Generation Cephalosporin Resistance Among Serovar Enteritidis Isolates in Shanghai, China Conferred by Harboring Plasmids.

In this study, we investigated the pattern of antimicrobial resistance in enterica serotype Enteritidis isolates in Shanghai, China from 2005 to 2014. We found the first isolates with resistance to the fourth-generation cephalosporin cefepime starting in 2010. Furthermore, we analyzed the epidemic characteristics and mechanisms of underlying cefepime resistance in Enteritidis isolates found from 2010.

Ciprofloxacin-Resistant Serovar Kentucky ST198 in Broiler Chicken Supply Chain and Patients, China, 2010-2016.

serovar Kentucky (. Kentucky) sequence type 198 has emerged as a global zoonotic pathogen. We explored serovar Kentucky ST198 samples from the broiler chicken supply chain and patients between 2010 and 2016.

Molecular epidemiology and antimicrobial resistance of invasive non-typhoidal in China, 2007-2016.

Purpose: Human infections caused by invasive non-typhoidal (iNTS) are highly prevalent worldwide. However, data for such infections in China are scarce. This study reports the epidemiology of iNTS in China.

Identifying subpathway signatures for individualized anticancer drug response by integrating multi-omics data.

Background: Individualized drug response prediction is vital for achieving personalized treatment of cancer and moving precision medicine forward. Large-scale multi-omics profiles provide unprecedented opportunities for precision cancer therapy.

Methods: In this study, we propose a pipeline to identify subpathway signatures for anticancer drug response of individuals by integrating the comprehensive contributions of multiple genetic and epigenetic (gene expression, copy number variation and DNA methylation) alterations.

High-levels of resistance to quinolone and cephalosporin antibiotics in MDR-ACSSuT Salmonella enterica serovar Enteritidis mainly isolated from patients and foods in Shanghai, China.

In this study, 2887 Salmonella strains were mainly obtained from patients and foods in Shanghai from 2006 to 2014 in order to assess the susceptibility to 16 antibiotics. Among them, 3.8% (110/2887) S.

Highly Prevalent Multidrug-Resistant From Chicken and Pork Meat at Retail Markets in Guangdong, China.

This study aimed to investigate the prevalence, serotype distribution, and antibiotic resistance, and to characterize the extended spectrum β-lactamases (ESBLs) producing isolates from chicken and pork meats from retail markets in Guangdong province, China. A total of 903 retail meat samples (475 chicken and 428 pork meats) were obtained from six cities (Guangzhou, Shenzhen, Heyuan, Shaoguan, Foshan, and Yunfu) of Guangdong province between May 2016 and April 2017. High levels of contamination were detected in chicken (302/475, 63.

Multi-tunable self-assembled morphologies of stimuli-responsive diblock polyampholyte films on solid substrates.

Intelligent polymers, due to their sensitive stimuli response to changes in the environment, have gained increasing amounts of attention over recent years and have become a popular topic in polymer materials science. In this study, the aggregation behaviors and stimuli responses of the stimuli-responsive diblock polyampholyte poly(2-(dimethylamino)ethyl methacrylate)-b-poly(acrylic acid) (PDMAEMA-b-PAA) are conveniently tunable by introducing pH changes, temperature changes, salt addition and surfactant neutralization. Under different pH values, either globular or fractal self-assemblies can be observed in which the latter have crystal properties.

Dual-stimuli responsive behaviors of diblock polyampholyte PDMAEMA-b-PAA in aqueous solution.

Two poly(2-(dimethylamino)ethyl methacrylate)-b-poly(acrylic acid) diblock copolymers, PDMAEMA(84)-b-PAA(18) and PDMAEMA(50)-b-PAA(18), were synthesized by the atom transfer radical polymerization (ATRP) and their dual-stimuli responsive behaviors to the changes in temperature and pH in aqueous solutions were investigated by UV-vis spectroscopy, dynamic light scattering (DLS), (1)H NMR spectroscopy and surface tension measurement. Different from PDMAEMA(84)-b-PAA(18) solutions where no aggregation is observed between pH 7.0 and 9.